Investigating The Clinical And Research Applications Of Whole-genome Sequencing In Parkinson Disease And Other Movement Disorders
Funder
National Health and Medical Research Council
Funding Amount
$266,623.00
Summary
There are many ‘movement disorders’ including Parkinson disease, dystonia, and hereditary spastic paraplegia. These disorders can be caused by mutations (errors in the genetic code) in different genes. The discovery of these genes has improved our understanding of the underlying disease mechanisms. We will use ‘whole genome sequencing’ to read a person’s entire genetic material in a single experiment, allowing us to identify a genetic diagnosis and to discover entirely new disease-causing genes.
Mapping Brain Network Interactions In Neurodegenerative Disorders Of The Subcortex
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Huntington’s disease, Parkinson’s disease, and Friedreich ataxia are debilitating and progressive neurodegenerative disorders that result from cell death within different components of a common brain system. Using magnetic resonance imaging and advanced statistical techniques, I will investigate functional and structural changes within this system, providing a clearer picture of the brain network changes that underlie the expression of these disorders.
Pedunculopontine Nucleus Stimulation For Gait Freezing And Postural Instability In Parkinson’s Disease
Funder
National Health and Medical Research Council
Funding Amount
$223,118.00
Summary
Over 64,000 Australians have Parkinson’s disease. Most patients with Parkinson’s disease ultimately develop gait ‘freezing’ and poor balance, which impair quality of life and cause falls. Unfortunately, gait freezing and poor balance often don’t improve with conventional treatments. We are therefore developing a new treatment for these symptoms, which involves implanting a pacemaker into a very deep brain region called the “Pedunculopontine Nucleus’.
A Convergent Approach To Define The Behavioural And Pathophysiological Signatures Of Neuropsychiatric Symptoms
Funder
National Health and Medical Research Council
Funding Amount
$350,889.00
Summary
Most people with Parkinson’s disease (PD) will experience neuropsychiatric symptoms. Currently, these complex symptoms are poorly understood and treatment options are limited. My project will use psychological tests, neuroimaging and pharmacological investigations, to identify the specific brain changes leading to neuropsychiatric symptoms. My goal is to advance our understanding of what causes these symptoms, so that we can develop effective treatments and improve quality of life in PD.
How Does The Trunk Influence Intersegmental Coordination During Functional Tasks In Parkinson’s Disease: A Risk Factor For Falls?
Funder
National Health and Medical Research Council
Funding Amount
$328,032.00
Summary
Differences in trunk motion during dynamic tasks may provide a mechanism of falling in Parkinson’s disease (PD) patients. However, objective measures are needed to discern if these differences stem from deficits in motor programming or increased trunk stiffness. This information is critical for developing effective interventions. This project will incorporate innovative techniques to examine how the trunk muscles coordinate movement and control balance during walking in PD.
A Comparative Study Between The Effects Of C-terminally Truncated A-synuclein Metabolites And Full Length A-synuclein In Aged Rat Hippocampal Neurons
Funder
National Health and Medical Research Council
Funding Amount
$231,284.00
Summary
I am a neurologist from Xi�an Jiaotong University, China. My major research interest is in neurodegenerative diseases, especially Parkinson and Alzheimer�s disease. I enter this field because I know ageing population will have an enormous impact on the world�s economy. I started collaboration with Dr. Weiping Gai in Flinders University. We are interested in the toxic effects of both a-synuclein and its metabolites, their mechanisms and ways to block them.
Utilising Advanced Functional MRI Techniques To Explore Attentional Network Dysfunction In Visual Hallucinations Across Disorders Of Dementia
Funder
National Health and Medical Research Council
Funding Amount
$427,682.00
Summary
Parkinson’s disease is a devastating neurological disorder that places a massive burden on society, but we know frustratingly little about the brain mechanisms underlying the disorder. My fellowship will enable me to learn cutting-edge functional brain imaging analysis techniques, and upon return to Australia, to apply those tools to reveal the dysfunctional brain mechanisms underlying visual hallucinations in Parkinson’s disease, facilitating earlier diagnosis and targeted therapies.
Identification Of Novel Regulatory Factors In Midbrain Development To Improve Cell Therapies For The Treatment Of Parkinson’s Disease
Funder
National Health and Medical Research Council
Funding Amount
$311,860.00
Summary
Cell transplantation is one of the most promising therapeutic strategies for the treatment of Parkinson’s disease. Cells are transplanted directly into the brain of the patient and can compensate for those lost to the disease. In this project we are identifying new genes that regulate the normal development of the transplanted cells in mice. We hope to use this knowledge to improve the reliability and effectiveness of the approach, bringing the therapy closer to the clinic.
Determining Neuronal Connections Involved In Parkinson's Disease And Cocaine Addiction
Funder
National Health and Medical Research Council
Funding Amount
$343,300.00
Summary
Addictive behaviours in response to cocaine use and fine motor coordination that is affected in Parkinson's disease are both controlled by the same type of cells/neurons, i.e., dopamine neurons. However, the circuitry of these neurons varies from where they originate and the type of connections they make. By understanding the neuronal circuitry of these two circuitries in concert we will be able to gain important insight into their roles in adaptive and pathological brain function.