Validation Of The Acceptability And Reliability Of Anal Swabs Used For Cytological Screening Among HIV+ MSM
Funder
National Health and Medical Research Council
Funding Amount
$76,108.00
Summary
This study will be screening HIV-positive men who have sex with men for Anal Squamous Intra-epithelial Lesions.These lesions, if left untreated, could develop into anal cancer. The study will take anal cytology swabs from 1000 HIV-positive men who attend the HIV clinic at St Vincent's hospital. Those men who are identified as having high-grade lesions (HSIL) or atypical cells (ASCUS) will be offered follow up by the principal investigator, Dr Richard Hillman.
Role Of Toll-like Receptor 7 In Rhinovirus-induced Asthma Exacerbation
Funder
National Health and Medical Research Council
Funding Amount
$697,248.00
Summary
One third of the annual asthma-related health care expenditure may be attributable to asthma-related hospitalisations. Even mild asthmatics experience severe exacerbations at a rate of almost one per year1 and those attacks can be fatal. Rhinovirus (RV) causes the majority of asthma exacerbations which may be linked to an impaired antiviral interferon (IFN) response in asthmatics. RV is sensed by Toll-like receptor (TLR) 7, but the role of this innate host defence pathway in regulating antiviral