Transient Tissue ‘priming’ Via FAK Inhibition To Impair Pancreatic Cancer Progression And Improve Sensitivity To Gemcitabine/Abraxane
Funder
National Health and Medical Research Council
Funding Amount
$643,848.00
Summary
The success of cancer drugs is dependent on many factors including the properties of the tumour tissue. As a tumour grows it changes the tissue around it, and this affects response to treatment. Combining classical biology with engineering to generate 3D models that mimic tumours, along with cutting-edge imaging technology and mouse models, we will target FAK-controlled cancer cell pathways that sense tissue changes, together with already approved cancer drugs to improve patient outcome.
Characterization Of Ras-Stimulated Macropinocytosis In Pancreatic Cancer
Funder
National Health and Medical Research Council
Funding Amount
$470,964.00
Summary
Pancreatic cancer (PC) is one of the most lethal human cancers, namely due to frequent late stage diagnosis. Thus, there is urgent need to better understand the biology of this disease. Cancer cells are characteristically more reliant on nutrients in order to sustain their growth, making them more vulnerable to inhibition of nutrient supplies. The key aim of this project is to better understand the ways in which PC cells take up nutrients so that these processes may potentially be blocked.
Global Characterization Of The Src-regulated Kinome
Funder
National Health and Medical Research Council
Funding Amount
$591,334.00
Summary
This proposal aims to use new cutting-edge techniques to globally characterize the impact of a particular cancer-causing gene, or oncogene, on the expression and function of an important family of regulatory proteins, termed kinases, in cancer cells. This will identify proteins critical for cancer cell growth and survival that represent potential targets for therapy.
Identification Of Novel Treatment Strategies For Human Cancers Through Integrative Phosphoproteomics And Kinomics.
Funder
National Health and Medical Research Council
Funding Amount
$763,409.00
Summary
This proposal aims to use new cutting-edge techniques to characterize, at a global level, changes in growth regulatory signals in cancer cells. This will identify proteins critical for cancer growth that represent potential targets for therapy. In addition it will highlight ways to select the most effective treatments for individual patients. The ultimate outcome of this work will be improved treatment strategies for cancer patients, and hence reduced morbidity and mortality.