Synthetic derivatives of capsaicin and gingerols as analgesics acting at the vanilloid receptor. This project aims to prepare alpha-hydroxyketones and gingerol derivatives acting at vanilloid (VR1) receptor with potential analgesic activity. These compounds will be tested for their ability to activate the VR1 receptor, desensitize the receptor and release neuropeptides associated with pain pathways. The development of these novel compounds will contribute towards understanding the mechanisms of ....Synthetic derivatives of capsaicin and gingerols as analgesics acting at the vanilloid receptor. This project aims to prepare alpha-hydroxyketones and gingerol derivatives acting at vanilloid (VR1) receptor with potential analgesic activity. These compounds will be tested for their ability to activate the VR1 receptor, desensitize the receptor and release neuropeptides associated with pain pathways. The development of these novel compounds will contribute towards understanding the mechanisms of VR1 receptor activation and provide information on how the VR1 receptor is regulated. We will determine and compare neurotoxicity of these compounds to capsaicin which is known to possess neurotoxic activity. The outcome of this project may result in effective agents for better pain management.
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Economic Operability Assessment of Leaching Process at Kwinana Nickel Refinery. Process operability is concerned with systematic analysis and improvement of process performance in the face of variable operating conditions. This project will develop a rigorous methodology for analysis of process operability with respect to short-term and transient disturbances. The proposed technique will be applied to the Kwinana Nickel Refinery Leach section, in order to reduce the plant variability and increas ....Economic Operability Assessment of Leaching Process at Kwinana Nickel Refinery. Process operability is concerned with systematic analysis and improvement of process performance in the face of variable operating conditions. This project will develop a rigorous methodology for analysis of process operability with respect to short-term and transient disturbances. The proposed technique will be applied to the Kwinana Nickel Refinery Leach section, in order to reduce the plant variability and increase nickel throughput and plant availability. This can be considered as significant move by a process industry to embrace advanced theoretical developments and will act as a benchmark to promote future links between Australian industry and academia.Read moreRead less
Advanced Nanoscale Materials Engineered from Diatomaceous Earth. Using natural materials of diatomaceous earth (DE) as a cheap and available resource by applying synthetic routes this project is directed towards the innovative development of new nanoscale materials with advanced properties. New mesoporous materials with intricate 3-D structures and nano sized features will be engineered from diatom silica for use in demanding applications such as separation and catalysis. These research outcomes ....Advanced Nanoscale Materials Engineered from Diatomaceous Earth. Using natural materials of diatomaceous earth (DE) as a cheap and available resource by applying synthetic routes this project is directed towards the innovative development of new nanoscale materials with advanced properties. New mesoporous materials with intricate 3-D structures and nano sized features will be engineered from diatom silica for use in demanding applications such as separation and catalysis. These research outcomes will enhance Australia's capacity in frontier technology and advanced materials, as well as bringing a competitive advantage to local industry through the development of such advanced materials.Read moreRead less
Field-Enhanced Electrospinning for Fine and Uniform Nanofibres. This project will result in a new platform technology to produce very fine and uniform nanofibres that can be used in a range of advanced applications. It will further strengthen our leading position in the field of nanofibre technology, and contribute to the National Research Priority area of Frontier Technologies for Building and Transforming Australian Industries. Australia already has niche expertise in nanomaterials. This proje ....Field-Enhanced Electrospinning for Fine and Uniform Nanofibres. This project will result in a new platform technology to produce very fine and uniform nanofibres that can be used in a range of advanced applications. It will further strengthen our leading position in the field of nanofibre technology, and contribute to the National Research Priority area of Frontier Technologies for Building and Transforming Australian Industries. Australia already has niche expertise in nanomaterials. This project will significantly enhance our international standing in the field. There is a growing list of local companies that are interested in exploring the production and application of nanofibrous materials also.Read moreRead less
Optimizing tailings dewatering through interfacial chemistry and particle interactions. This project aims to improve the dewatering behaviour of waste tailings from mineral processing activites. Dewatering and disposal of tailings containing fine particles are serious issues which confront the mineral industry. Effective dewatering of tailings is determined by particle-solution interfacial chemistry and particle interactions. These properties will be manipulated by matching the molecular arch ....Optimizing tailings dewatering through interfacial chemistry and particle interactions. This project aims to improve the dewatering behaviour of waste tailings from mineral processing activites. Dewatering and disposal of tailings containing fine particles are serious issues which confront the mineral industry. Effective dewatering of tailings is determined by particle-solution interfacial chemistry and particle interactions. These properties will be manipulated by matching the molecular architecture and functionality of flocculants to mineral particle surface chemistry. Optimization of tails interfacial chemistry and particle interactions through conventional and non-conventional flocculants will be investigated and electoosmosis will be applied to achieve maximum dewatering behaviour.The scientific and environmental outcomes will be beneficial to all stakeholders.Read moreRead less
Optimising Froth Zone Performance in Mineral Flotation. Froth flotation is the most widely applied technique for the selective separation of valuable mineral from gangue mineral particles. This project aims to optimize the selective separation of valuable minerals from gangue minerals within the froth zone of flotation. This project has very high national significance as deficiencies in the froth zone performance of industrial flotation plants, leads to a significant loss of valuable mineral f ....Optimising Froth Zone Performance in Mineral Flotation. Froth flotation is the most widely applied technique for the selective separation of valuable mineral from gangue mineral particles. This project aims to optimize the selective separation of valuable minerals from gangue minerals within the froth zone of flotation. This project has very high national significance as deficiencies in the froth zone performance of industrial flotation plants, leads to a significant loss of valuable mineral from mineral concentrates, as well as a reduction in concentrate grade and quality. An expected outcome of this project will be a series of new tools and methodologies to optimize froth zone performance, which will have industry wide application.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0454008
Funder
Australian Research Council
Funding Amount
$340,962.00
Summary
Multi-function high resolution-analytical scanning electron microscope facility. The aim of this proposal is to establish a high resolution electron microscope facility as part of a comprehensive materials characterisation infrastructure required to support Swinburne's expanding activities in nanotechnology. A high resolution SEM in conjunction with an upgrade of the current SEM will provide advanced instrumentation for nanoscale imaging, analysis and manipulation of materials. The proposed faci ....Multi-function high resolution-analytical scanning electron microscope facility. The aim of this proposal is to establish a high resolution electron microscope facility as part of a comprehensive materials characterisation infrastructure required to support Swinburne's expanding activities in nanotechnology. A high resolution SEM in conjunction with an upgrade of the current SEM will provide advanced instrumentation for nanoscale imaging, analysis and manipulation of materials. The proposed facility will create new opportunities for collaborative programs with local and overseas researcher and will facilitate rapid progress in research programs across the entire University in particular those related to two ARC Centres of Excellence in which the University is a core partner.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0345760
Funder
Australian Research Council
Funding Amount
$210,000.00
Summary
Nanoscale Interaction Forces in Particulate and Molecular Systems. We seek to establish a world-class facility for the measurement of nanoscale interaction forces. The ability to measure forces between particles, polymers, emulsion droplets, bubbles, proteins and powders will augment our research capabilities in minerals and material processing, thin film technology, structured surfaces, and in molecular and bio-technology (eg. proteins, DNA, cells, bone, bio-implants). A Molecular Force Probe ....Nanoscale Interaction Forces in Particulate and Molecular Systems. We seek to establish a world-class facility for the measurement of nanoscale interaction forces. The ability to measure forces between particles, polymers, emulsion droplets, bubbles, proteins and powders will augment our research capabilities in minerals and material processing, thin film technology, structured surfaces, and in molecular and bio-technology (eg. proteins, DNA, cells, bone, bio-implants). A Molecular Force Probe (Asylum Research) instrument will allow precise and flexible force measurements on the nano-metre scale. The proposed multi-disciplinary facility will advance research in the areas of engineering, chemistry, pharmacology and biotechnology.
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Cellular and network basis of information processing in the mammalian visual system. The project aims to discover the strategies by which cells in the brain interact with each other to code the sensory input efficiently. It is expected that simultaneous recording of the activity of many neurones from the visual cortex of anaesthetised cats during visual stimulation will reveal how the biophysics of synaptic integration combined with excitatory and inhibitory inputs from different sources sculpt ....Cellular and network basis of information processing in the mammalian visual system. The project aims to discover the strategies by which cells in the brain interact with each other to code the sensory input efficiently. It is expected that simultaneous recording of the activity of many neurones from the visual cortex of anaesthetised cats during visual stimulation will reveal how the biophysics of synaptic integration combined with excitatory and inhibitory inputs from different sources sculpts the output of individual neurones. The experiments will be extended to the study of possible interactions between different areas of the brain and the study of mechanisms by which the cortical network and higher cognitive factors such as attention and memory might influence the coding of sensory information in awake animals.Read moreRead less
Template-free Control of Titania Precipitation from Homogeneous Aqueous Solution. Used in the paint, plastic, ceramic, paper and synthetic fibre industries and having strategic nano-technological applications, titania is an important commodity for Australia, earning about $1.3 billion p.a. in exports. Better production methods through improved understanding of titania precipitation chemistry will help to increase our industrial productivity and minimise energy consumption. It may also lead to us ....Template-free Control of Titania Precipitation from Homogeneous Aqueous Solution. Used in the paint, plastic, ceramic, paper and synthetic fibre industries and having strategic nano-technological applications, titania is an important commodity for Australia, earning about $1.3 billion p.a. in exports. Better production methods through improved understanding of titania precipitation chemistry will help to increase our industrial productivity and minimise energy consumption. It may also lead to useful new processes and/or materials with catalytic properties. In an increasingly competitive global market, this is most relevant to Australian titania exporters and to Australian renewable energy programs (particularly for generating photovoltaic power). Read moreRead less