Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
Spinal Cord Injury Pain: Understanding Mechanisms To Develop Treatments
Funder
National Health and Medical Research Council
Funding Amount
$597,675.00
Summary
Spinal cord injury has devastating effects on health and quality of life. Many of the major consequences of injury, such as chronic pain and loss of voluntary voiding, are "invisible" – i.e., they are not as visible as limitations of mobility. Our study aims to define the neurobiological changes that cause development of persistent pain after spinal cord injury and use pharmacological tools to attenuate the development of pain.
Special Research Initiatives - Grant ID: SR0354596
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Perception and Action in Auditory Scenes (PAAS): Neural, Behavioural, Computational and Mechanical Systems. Auditory scenes are temporal and ephemeral yet pervasively influence human life. How humans negotiate such scenes has not been solved, a fact highlighted by attempts to build machines to respond to speech, warnings etc., in real-world situations with room reverberation, different talkers, and background noise. No one discipline can solve such problems. In this network outstanding researche ....Perception and Action in Auditory Scenes (PAAS): Neural, Behavioural, Computational and Mechanical Systems. Auditory scenes are temporal and ephemeral yet pervasively influence human life. How humans negotiate such scenes has not been solved, a fact highlighted by attempts to build machines to respond to speech, warnings etc., in real-world situations with room reverberation, different talkers, and background noise. No one discipline can solve such problems. In this network outstanding researchers from physical, medical, human, and social sciences with interests in speech, music and audition will provide insights into how humans and machines localize, recognize, interpret and produce auditory events, and advance frontier technologies, e.g., automatic speech recognition, hearing prostheses, auditory monitoring/warning systems.Read moreRead less
Learning from our mistakes: How and when complex decisions fail. The project aims to develop a novel mathematical framework, augmented by simulations and a set of experiments, to study when and how people commit errors. The modern environment bombards us with signals, such as radio and television advertisements as we sit at home or warning lights and car honks as we cross the road. Despite years of psychological research, it is not entirely clear how efficiently people cope with increasing amoun ....Learning from our mistakes: How and when complex decisions fail. The project aims to develop a novel mathematical framework, augmented by simulations and a set of experiments, to study when and how people commit errors. The modern environment bombards us with signals, such as radio and television advertisements as we sit at home or warning lights and car honks as we cross the road. Despite years of psychological research, it is not entirely clear how efficiently people cope with increasing amounts of information nor is it clear whether they process multiple signals simultaneously (in parallel) or one after the other (serial). The project offers new measures, based on the rate and pattern of error responses, to supplement the commonly used response times. The combination of a theoretical framework, based on mathematical and computational work, with empirical data to test the models, may deliver a better understanding of human performance and its limitations.Read moreRead less
The Role of Colour and Luminance in Spatial Location. How does the brain form our impression of the world? Black and white images appear normal to us. However, colour images without luminance variation have little depth, suggesting that the brain does not process colour in the same way as luminance. A series of fresh experiments examine how colour and luminance are utilised for seeing the depth and position of objects. The results will help us to understand how the first stages of visual process ....The Role of Colour and Luminance in Spatial Location. How does the brain form our impression of the world? Black and white images appear normal to us. However, colour images without luminance variation have little depth, suggesting that the brain does not process colour in the same way as luminance. A series of fresh experiments examine how colour and luminance are utilised for seeing the depth and position of objects. The results will help us to understand how the first stages of visual processing in the brain shape our sense of the world, and help develop theories of human vision, as well as animal and machine models of vision.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100125
Funder
Australian Research Council
Funding Amount
$385,536.00
Summary
Human visual perception: Connecting genes, brain and behaviour. This project aims to reveal the relationship between genes, brain and behaviour in visual perception, where underlying brain activity can be decoded from electrical signals. Modern molecular genetics promises unprecedented insights into human psychology. But progress has been slower than expected because the brain mechanisms linking genes to behaviours are incredibly complex. Project results are expected to show how common variation ....Human visual perception: Connecting genes, brain and behaviour. This project aims to reveal the relationship between genes, brain and behaviour in visual perception, where underlying brain activity can be decoded from electrical signals. Modern molecular genetics promises unprecedented insights into human psychology. But progress has been slower than expected because the brain mechanisms linking genes to behaviours are incredibly complex. Project results are expected to show how common variations in genes affect our brain's response to visual stimulation, and how this in turn alters our perceptual experience and behavioural reactions. These discoveries aim to cast new light on the architecture and development of the mind, and provide a new model for investigating the genetic basis of other psychological traits.Read moreRead less
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
The effect of cochlear implants on cognitive decline in ageing Australians. This project aims to investigate the impact of cochlear implants on cognitive function in elderly people with deafness. Deafness has been found to be independently associated with a 30–40 per cent accelerated rate of cognitive decline in elderly adults. There is currently no effective treatment for cognitive decline. The intended outcomes of this observational study will help us to understand the biological process of co ....The effect of cochlear implants on cognitive decline in ageing Australians. This project aims to investigate the impact of cochlear implants on cognitive function in elderly people with deafness. Deafness has been found to be independently associated with a 30–40 per cent accelerated rate of cognitive decline in elderly adults. There is currently no effective treatment for cognitive decline. The intended outcomes of this observational study will help us to understand the biological process of cognitive decline, whether hearing loss is causal, and whether the process can be altered. These findings should be applicable to all individuals with hearing loss. If cochlear implants delay cognitive decline, this would significantly affect policy, quality of life for the elderly, and the cost to society.Read moreRead less
Developing a Unified Theory of Episodic Memory. This project aims to develop a model of episodic memory and to apply the model to both adult and child development data. Unlike current approaches, the model is expected to address multiple memory tasks including item recognition, associative recognition, source recognition and cued recall, and also aims to address reaction time data, allowing different sources of interference causing forgetting in adults to be identified. By addressing both encodi ....Developing a Unified Theory of Episodic Memory. This project aims to develop a model of episodic memory and to apply the model to both adult and child development data. Unlike current approaches, the model is expected to address multiple memory tasks including item recognition, associative recognition, source recognition and cued recall, and also aims to address reaction time data, allowing different sources of interference causing forgetting in adults to be identified. By addressing both encoding and retrieval processes, the model can assess how changes in different sources of interference modulate performance through the trajectory of early development. Hierarchical Bayesian estimation aims to enable a simultaneous account of multiple tasks and support future deployment in applied contexts.Read moreRead less
Creating perceptual experts in Australia's policing and security agencies. This project aims to create the next generation of experts in Australia’s policing and national security agencies, by improving crime scene evidence interpretation. Agencies are under pressure to develop more rigorous training practices that go beyond mere intuition and tradition. This project will use a novel approach that directs learning toward the most diagnostic perceptual cues. Expected outcomes include a solid empi ....Creating perceptual experts in Australia's policing and security agencies. This project aims to create the next generation of experts in Australia’s policing and national security agencies, by improving crime scene evidence interpretation. Agencies are under pressure to develop more rigorous training practices that go beyond mere intuition and tradition. This project will use a novel approach that directs learning toward the most diagnostic perceptual cues. Expected outcomes include a solid empirical basis for national training programs designed to create experts that are accurate, reliable, and continuously improving. Improving the training of experts will ensure the integrity of forensics as evidentiary tools available to police, lead to more reliable courtroom convictions and help safeguard Australia from terrorism and crime.Read moreRead less