The Analgesic Evaluation Of Novel Natural Products From The Australian Plant Barringtonia Acutangula
Funder
National Health and Medical Research Council
Funding Amount
$174,500.00
Summary
This project aims to evaluate the analgesic activity of several novel natural products that have been isolated from the Australian plant Barringtonia acutangula. An Australian Aboriginal tribe have been known to use B. acutangula aqueous bark extracts for its analgesic properties. Griffith University researchers have confirmed this biological activity in the crude aqueous bark extract. A large scale extraction and isolation process will obtain the novel compounds in sufficient quantities that wi ....This project aims to evaluate the analgesic activity of several novel natural products that have been isolated from the Australian plant Barringtonia acutangula. An Australian Aboriginal tribe have been known to use B. acutangula aqueous bark extracts for its analgesic properties. Griffith University researchers have confirmed this biological activity in the crude aqueous bark extract. A large scale extraction and isolation process will obtain the novel compounds in sufficient quantities that will allow for their pharmacological evaluation as potential analgesic drugs.Read moreRead less
Spinal complaints present the greatest social and economic burden of musculoskeletal conditions in Australia. This reflects current realities: the cause remains unknown; 80% of the population is affected; and isolated professions perform a staggering array of interventions. The CCRE aims to target these realities and improve Australia's capacity to prevent and manage spinal disorders by supporting innovative interdisciplinary research and training. This community- and university-based centre wil ....Spinal complaints present the greatest social and economic burden of musculoskeletal conditions in Australia. This reflects current realities: the cause remains unknown; 80% of the population is affected; and isolated professions perform a staggering array of interventions. The CCRE aims to target these realities and improve Australia's capacity to prevent and manage spinal disorders by supporting innovative interdisciplinary research and training. This community- and university-based centre will align highly successful clinical and basic researchers in collaboration with a national network of spine scientists to foster interdisciplinary clinical researcher training, develop new diagnostics and therapeutics, and translate findings to the community. Through clinical research the centre aims to: (i) Advance understanding of physiology and pathophysiology of spinal pain (ii) Translate findings from basic research to clinical practice (iii) Establish coordinated multidisciplinary research to reduce the burden of spinal pain (iv) Predict and prevent the transition from acute to chronic states (v) Train a new generation of transdisciplinary clinical scientists (vi) Rapidly assess new treatment possibilities in pre-clinical studies (vii) Develop innovative technologies for diagnostics and therapeutics (viii) Encourage Australian commercialisation opportunities for new discoveries (ix) Encourage community-user participation in direction of research programs (x) Disseminate new findings and information of evidence-based practice to patients, clinicians, insurers, government and the scientific and wider communityRead moreRead less
Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
Efficacy Of Prism Adaptation For Recovery Of Brain Function In Unilateral Spatial Neglect
Funder
National Health and Medical Research Council
Funding Amount
$531,690.00
Summary
Damage to the brain’s attention network causes profound impairments of visual and sensory perception. These deficits are frequently long-lasting, and are a major factor in preventing patients from regaining functional independence. This project will use a combination of behavioural and brain imaging techniques to determine whether a promising new treatment involving visual retraining can improve function and reduce perceptual impairments after unilateral brain lesions.
Physiotherapist Led Stress Inoculation Intervention Integrated With Exercise For Acute Whiplash Injury
Funder
National Health and Medical Research Council
Funding Amount
$518,960.00
Summary
Physical and mental health outcomes following whiplash injury due to a road traffic crash are poor. Early stress system responses are associated with poor recovery. This study will investigate the effectiveness of a physiotherapist led stress inoculation intervention integrated with currently recommended exercise rehabilitation to improve health outcomes after whiplash injury.
Discovery Early Career Researcher Award - Grant ID: DE180100433
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Cortical layer specific functional imaging of the human brain. This project aims to record layer specific cortical activity in humans by leveraging ultra-high field magnetic resonance imaging. It expects to yield robust techniques for the general analysis of neuroimaging-based, layer-specific measurements. This project will progress the fields of cognitive neuroscience and neuroimaging as well as bring the field of neuroimaging closer to that of neurophysiology and thus facilitate collaboration ....Cortical layer specific functional imaging of the human brain. This project aims to record layer specific cortical activity in humans by leveraging ultra-high field magnetic resonance imaging. It expects to yield robust techniques for the general analysis of neuroimaging-based, layer-specific measurements. This project will progress the fields of cognitive neuroscience and neuroimaging as well as bring the field of neuroimaging closer to that of neurophysiology and thus facilitate collaboration among researchers.Read moreRead less
A Scalable Theory of Behavior Composition for Practical Engineering Models of Human Performance. Minimizing human error and maximizing human performance is a major design goal in safety critical systems. The development of methods for affordable human performance modeling has widespread applicability for evaluating user-system interfaces. The compositional method explored here has been shown to make accurate predictions reduce model development time by an order of magnitude. Large safety critica ....A Scalable Theory of Behavior Composition for Practical Engineering Models of Human Performance. Minimizing human error and maximizing human performance is a major design goal in safety critical systems. The development of methods for affordable human performance modeling has widespread applicability for evaluating user-system interfaces. The compositional method explored here has been shown to make accurate predictions reduce model development time by an order of magnitude. Large safety critical applications, such as military or air traffic control systems, would benefit greatly. The proposed work tests whether the compositional methods will scale to more complex domains. The work will be coordinated with Australian industry, academia, and government research efforts.Read moreRead less
A Sequential Multiple Assignment Randomised Trial (SMART) Of Nursing Interventions To Reduce Pain Associated With Chemotherapy Induced Peripheral Neuropathy
Funder
National Health and Medical Research Council
Funding Amount
$713,418.00
Summary
Modern chemotherapy treatments can result in damage to the peripheral nerves, resulting in a condition called peripheral neuropathy. This condition is characterised by a range of sensory and functional changes that can cause pain and reduced ability to perform daily activities. This project will test various non-pharmacological pain management measures to determine if they are effective in improving the quality of life of patients who experience this problem.
Determinants and consequences of conscious visual awareness. Usually salient images can disappear from awareness without corresponding stimulus changes. This project is based on an innovative account linking such disappearances to a functional adaptation which facilitates vision in cluttered environments. Project completion will expand Australia's knowledge base, forge links between junior and senior Australian based investigators and provide excellent training opportunities. Publication of rese ....Determinants and consequences of conscious visual awareness. Usually salient images can disappear from awareness without corresponding stimulus changes. This project is based on an innovative account linking such disappearances to a functional adaptation which facilitates vision in cluttered environments. Project completion will expand Australia's knowledge base, forge links between junior and senior Australian based investigators and provide excellent training opportunities. Publication of research in top-ranking international journals will further promote Australian science abroad. Ultimately, this research will have implications for the design and implementation of artificial visual systems, which must overcome many of the same dilemmas faced by the human visual system in cluttered environments.Read moreRead less
Human Time Perception. Most human tasks require timing on a scale of tens to hundreds of milliseconds. We must judge time to produce and comprehend speech, to move about and interact with our dynamic environment, to determine causality and decode information from sensory receptors. However, the neural bases of time perception are largely unknown. This project will explore temporal phenomena to determine how and where durations, temporal order and coincidence are encoded in the human brain. Proje ....Human Time Perception. Most human tasks require timing on a scale of tens to hundreds of milliseconds. We must judge time to produce and comprehend speech, to move about and interact with our dynamic environment, to determine causality and decode information from sensory receptors. However, the neural bases of time perception are largely unknown. This project will explore temporal phenomena to determine how and where durations, temporal order and coincidence are encoded in the human brain. Project results will provide new insight into the mechanisms of time perception, with implications for disorders associated with impaired time perception, such as autism, dyslexia and schizophrenia.Read moreRead less