Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
Rod-cone interaction under mesopic illumination. Visual function and performance can be degraded under dim light levels. This occurs in many indoor settings, emergency and traffic lighting conditions. Approximately 45% of all Australian traffic fatalities occur under dim light. The research program uses a frontier technology to determine how vision is degraded under dim lighting and provide accurate parameters to better design mesopic lighting environments to maximize visual function and perform ....Rod-cone interaction under mesopic illumination. Visual function and performance can be degraded under dim light levels. This occurs in many indoor settings, emergency and traffic lighting conditions. Approximately 45% of all Australian traffic fatalities occur under dim light. The research program uses a frontier technology to determine how vision is degraded under dim lighting and provide accurate parameters to better design mesopic lighting environments to maximize visual function and performance. This work will help to evaluate new energy-efficient lighting systems and optimise traffic lighting for early recognition of obstacles and dangerous situations. Read moreRead less
Psychophysical Assessment of Receptoral and Post-Receptoral Visual Function. Visual function and performance can be degraded under dim light levels. This occurs in many indoor settings, emergency lighting and road traffic lighting conditions. Approximately 45% of all Australian road traffic fatalities occur under dim lighting conditions. My data will be unique, as it will provide accurate parameters to better design mesopic lighting environments to maximize visual function and performance. This ....Psychophysical Assessment of Receptoral and Post-Receptoral Visual Function. Visual function and performance can be degraded under dim light levels. This occurs in many indoor settings, emergency lighting and road traffic lighting conditions. Approximately 45% of all Australian road traffic fatalities occur under dim lighting conditions. My data will be unique, as it will provide accurate parameters to better design mesopic lighting environments to maximize visual function and performance. This work will help to optimise road traffic lighting for the early recognition of obstacles and dangerous situations. The research program will make important scientific contributions to understanding human visual function and performance at dim light levels.Read moreRead less
The role of the immune system in pain is emerging from recent discoveries, and may hold the key to novel pain treatments. Most people experience brief gut infections from food or contagion without long-term consequences. Many others suffer symptoms for years afterwards - probably the best example of immune-based pain. Our project investigates how immune cells communicate with sensory nerves, and how these communications change from both angles after gut infection or inflammation.