Chronic inflammation underlies common and debilitating diseases and causes pain by unknown mechanisms. There is an urgent need to gain a deeper understanding of the mechanisms of chronic pain, which will allow the development of improved therapies with fewer side-effects. Our research program investigates the mechanisms of pain that are associated with inflammatory bowel disease and irritable bowel syndrome, with the goal of developing more effective and selective therapies.
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
Technological innovation and change in supply chain integration. In examining emerging technology that can transform the performance of Australian industry we address the following priority goals: better understanding the processes that will advance knowledge and facilitate the development of technological innovations; the potential application of Radio Frequency Identification (RFID) technologies across an entire supply chain; and the improved management of information in the storage, distribut ....Technological innovation and change in supply chain integration. In examining emerging technology that can transform the performance of Australian industry we address the following priority goals: better understanding the processes that will advance knowledge and facilitate the development of technological innovations; the potential application of Radio Frequency Identification (RFID) technologies across an entire supply chain; and the improved management of information in the storage, distribution, and delivery of products (smart information use). Improvement in the operational efficiency and performance of the supply chain will increase national wealth while minimising environmental impacts on the environment, for example, through the better utilisation of heavy freight carriers.Read moreRead less
The psychological contract: Bridging human resource management practices and organisational effectiveness. Many managers believe that recent changes in management practice are responsible for Australia's high labour productivity but very little is known about the mechanisms through which such effects are transmitted. Will HRM enable Australian organisations to generate and maintain a competitive advantage in the global context? In this project we draw on theoretical frameworks established in ....The psychological contract: Bridging human resource management practices and organisational effectiveness. Many managers believe that recent changes in management practice are responsible for Australia's high labour productivity but very little is known about the mechanisms through which such effects are transmitted. Will HRM enable Australian organisations to generate and maintain a competitive advantage in the global context? In this project we draw on theoretical frameworks established in the behavioural sciences to understand how HRM practices influence employee reactions and impact organisational effectiveness, such as labour productivity. The results will be of direct benefit to Australian organisations designing, evaluating, or reconfiguring their HRM practices in line with their competitive strategy.Read moreRead less
Employment systems and organisational outcomes: Managing employee expectations through HRM practice. This project contributes to our understanding of the factors that influence organisational effectiveness. Australian employers are facing competitive business conditions and changing demographics. In this challenging environment, employers and employees must develop a clear understanding of what they can expect from one another. Unfulfilled expectations can lead to workplace cynicism and have ....Employment systems and organisational outcomes: Managing employee expectations through HRM practice. This project contributes to our understanding of the factors that influence organisational effectiveness. Australian employers are facing competitive business conditions and changing demographics. In this challenging environment, employers and employees must develop a clear understanding of what they can expect from one another. Unfulfilled expectations can lead to workplace cynicism and have a negative effect on organisational performance. The project findings will help organisations become more competitive in the global marketplace by designing HRM practice configurations that are best fit to the needs of their employees and that establish converging expectations about the employment relationship.Read moreRead less
Testing the integration and differentiation of national employment systems: multinational enterprises in an international comparative context. Multinational enterprises play a leading role in shaping employment practices as their power disproportionately influences the direction of change in managing people. This project, conducted across six countries, enhances our understanding of how these organisations influence and shape the employment practices and systems in host contexts.
Behind the scenes: diversity management paradigm shifts and sticking points. Many Australian organisations miss out on the potential benefits of workforce diversity because they do not manage diversity effectively. This project will investigate how organisations can initiate and direct change processes to manage diversity more effectively, and as a result, experience higher productivity and employee engagement.
The impact of institutional pressure on the management of organisational gender diversity. Women’s low representation in senior management and boards led to the Australian Securities Exchange (ASX) requiring listed companies to report on gender diversity. This project examines if women’s representation is changing in response to the ASX requirements and identifies organisational strategies for achieving sustainable gender diversity.
The reality of China's socialist market economy: the emergence of labour segmentation and inequality. Australia's current regional and economic security is predicated on China's stability and prosperity. This project provides a unique opportunity for Australian organisations and institutions to gain a better understanding of the complex economic, regulatory and social issues that surround the problem of labour segmentation and inequality in China.
New approach to sensitivity assessment of complex simulation models for environmental management. The aims are (1) to develop new techniques that improve and extend the capabilities of sensitivity analysis of large and complex computer models for environmental management; and (2) with the industry partners, to test these techniques on models for salinity management in the Murray-Darling Basin. The project's significance is in providing new techniques able to answer a range of model users? questi ....New approach to sensitivity assessment of complex simulation models for environmental management. The aims are (1) to develop new techniques that improve and extend the capabilities of sensitivity analysis of large and complex computer models for environmental management; and (2) with the industry partners, to test these techniques on models for salinity management in the Murray-Darling Basin. The project's significance is in providing new techniques able to answer a range of model users? questions at acceptable computational cost, for complex models with outputs measured in a wide variety of ways. The outcomes will be new sensitivity assessment tools and experience of their use in an environmental application of great importance to Australia.Read moreRead less