Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
Spinal Cord Injury Pain: Understanding Mechanisms To Develop Treatments
Funder
National Health and Medical Research Council
Funding Amount
$597,675.00
Summary
Spinal cord injury has devastating effects on health and quality of life. Many of the major consequences of injury, such as chronic pain and loss of voluntary voiding, are "invisible" – i.e., they are not as visible as limitations of mobility. Our study aims to define the neurobiological changes that cause development of persistent pain after spinal cord injury and use pharmacological tools to attenuate the development of pain.
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
The Impact of Enterprise Resource Planning Systems on Australian Organizations. Enterprise Resource Planning (ERP) implementation is one of the most pervasive sources of technological change in contemporary Australian enterprises. ERP systems are computer-based technologies that are designed to increase efficiency and achieve major cost savings across the entire organization. Their implementation has significant implications for the structure, nature and management of organizations. This project ....The Impact of Enterprise Resource Planning Systems on Australian Organizations. Enterprise Resource Planning (ERP) implementation is one of the most pervasive sources of technological change in contemporary Australian enterprises. ERP systems are computer-based technologies that are designed to increase efficiency and achieve major cost savings across the entire organization. Their implementation has significant implications for the structure, nature and management of organizations. This project's innovative application of an organizational change model to eight detailed case studies across a range of organizational types will generate important new insights into the effects of ERP implementations at Australian organizations and help explain why some implementations are more successful than others.Read moreRead less
Managing age in organisational context: a comparative study of the meaning of age among managers. Australians are currently being encouraged to work longer to maximise their contribution to the economy but they often report there are organisational barriers to doing so. This study offers a new approach to understanding age focusing on managers and offers a framework of effective strategies for employers in managing age.
Risk and Change In Institutional Fields: The Case Of Industrial Chemicals. This project aims to explore how to manage risk through sustainable organisational strategies and institutional transformations. Chemical risks arise as by-products of economic and technological progress and can cause untold harm to human health and the environment. Using a discursive approach to compare how organisations in Australia and Canada manage chemical risks, this project aims to show how organisations can act as ....Risk and Change In Institutional Fields: The Case Of Industrial Chemicals. This project aims to explore how to manage risk through sustainable organisational strategies and institutional transformations. Chemical risks arise as by-products of economic and technological progress and can cause untold harm to human health and the environment. Using a discursive approach to compare how organisations in Australia and Canada manage chemical risks, this project aims to show how organisations can act as institutional entrepreneurs and introduce sustainable field-level solutions to risk, instead of relying on government regulation to deal with dangerous chemicals. The intended outcomes include the development of a model that identifies the challenges associated with three different risk scenarios – managing established risks, managing emerging risks and eliminating risks – as well as identifying and evaluating strategies to address these challenges.Read moreRead less
Organisational Behaviour in the Victoria Police Force. One of the major challenges facing managers in the Victoria Police is to create working environments that provide employees with the best possible chance of achieving organisational objectives. Subsequently, the aim of this project is to investigate a comprehensive model of organisational behaviour that employs the psychological contract approach and an augmented job strain model to predict employee attitudes and behaviour over time. The com ....Organisational Behaviour in the Victoria Police Force. One of the major challenges facing managers in the Victoria Police is to create working environments that provide employees with the best possible chance of achieving organisational objectives. Subsequently, the aim of this project is to investigate a comprehensive model of organisational behaviour that employs the psychological contract approach and an augmented job strain model to predict employee attitudes and behaviour over time. The combined project model goes beyond the typical studies in this field by incorporating cutting-edge issues such as organisational citizenship behaviours. The Victoria Police is highly committed to this project and believes that the successful execution of this project will contribute to its strategic goals.Read moreRead less
Innovation in Australian mid-market firms: The critical role of leader cognition. The innovation literature has focused on innovation in large corporations and small entrepreneurial firms, ignoring medium-sized firms. With a rare opportunity to work with a partner organisation on a range of mid-market firms, the project aims to focus on the unique theoretical aspects of innovation in medium-sized firms. The project’s investigation addresses critical gaps in the innovation strategy literature and ....Innovation in Australian mid-market firms: The critical role of leader cognition. The innovation literature has focused on innovation in large corporations and small entrepreneurial firms, ignoring medium-sized firms. With a rare opportunity to work with a partner organisation on a range of mid-market firms, the project aims to focus on the unique theoretical aspects of innovation in medium-sized firms. The project’s investigation addresses critical gaps in the innovation strategy literature and contributes to a nascent literature on the microfoundations of organisational outcomes. Specifically, the project focuses on how leader cognitions drive the intensity and type of innovation and influence the performance consequences of innovation. The project also aims to provide practical prescriptions to medium-sized firms in Australia.Read moreRead less
Technological innovation and change in supply chain integration. In examining emerging technology that can transform the performance of Australian industry we address the following priority goals: better understanding the processes that will advance knowledge and facilitate the development of technological innovations; the potential application of Radio Frequency Identification (RFID) technologies across an entire supply chain; and the improved management of information in the storage, distribut ....Technological innovation and change in supply chain integration. In examining emerging technology that can transform the performance of Australian industry we address the following priority goals: better understanding the processes that will advance knowledge and facilitate the development of technological innovations; the potential application of Radio Frequency Identification (RFID) technologies across an entire supply chain; and the improved management of information in the storage, distribution, and delivery of products (smart information use). Improvement in the operational efficiency and performance of the supply chain will increase national wealth while minimising environmental impacts on the environment, for example, through the better utilisation of heavy freight carriers.Read moreRead less
Visualising Value in Australian Organisations: Case Studies in Extended Performance Management, Measurement and Reporting. This research positions and develops Australia at the forefront of the knowledge economy. Participating organisations will realise insights into their invisible resources and improve their understanding of the performance, utilisation and productivity of their intangible resources. Corporate social responsibility and social and environmental management are recognized as cruc ....Visualising Value in Australian Organisations: Case Studies in Extended Performance Management, Measurement and Reporting. This research positions and develops Australia at the forefront of the knowledge economy. Participating organisations will realise insights into their invisible resources and improve their understanding of the performance, utilisation and productivity of their intangible resources. Corporate social responsibility and social and environmental management are recognized as crucial to the contemporary organisation and this research provides a means of managing, measuring and reporting these perspectives, enhancing Australia's reputation and long-term economic sustainability. Read moreRead less