Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
Promoting Knowledge Economy Organisations and Innovative Work: Regional influences on Knowledge-based Small and Medium-sized Enterprise clusters in Australia and Germany. In both Australia and Germany many regional areas have experienced economic and social decline. Clusters offer a means of fostering local economic development thereby arresting regional social and economic deterioration. The research focuses on those clusters that rely on knowledge transfer between organisations. Through identi ....Promoting Knowledge Economy Organisations and Innovative Work: Regional influences on Knowledge-based Small and Medium-sized Enterprise clusters in Australia and Germany. In both Australia and Germany many regional areas have experienced economic and social decline. Clusters offer a means of fostering local economic development thereby arresting regional social and economic deterioration. The research focuses on those clusters that rely on knowledge transfer between organisations. Through identifying the drivers and impediments to the formation of knowledge based clusters, the research aims to provide practical guidance to regionally-based organizations to assist in the successful formation and maintenance of clusters. In doing so, the research will identify how clusters that rely on the sharing of organizational knowledge may promote greater regional employment possibilities.Read moreRead less
Organisational Readiness for Enterprise Resource Planning Implementation. An ERP implementation is a significant organisational intervention and its success is affected by many variables including the organisation's culture, decision-making strategies, risk taking orientation, leadership strategies and perceptions of the value of Information Technology. We seek to develop a organisational behaviour modification program in order to position the firm to succeed by overcoming barriers in these ele ....Organisational Readiness for Enterprise Resource Planning Implementation. An ERP implementation is a significant organisational intervention and its success is affected by many variables including the organisation's culture, decision-making strategies, risk taking orientation, leadership strategies and perceptions of the value of Information Technology. We seek to develop a organisational behaviour modification program in order to position the firm to succeed by overcoming barriers in these elements. We will (1) identify key variables that inhibit an ERP implementation; (2) develop strategies to orient the organisation to achieve business benefit from the ERP implementation; and (3) track the effectiveness of these strategies through a program of participative action research.Read moreRead less
Examining the effectiveness of co-creation practices on health outcomes. This projects aims to examine how patients interact collaboratively with multiple stakeholders in a health system (co-creation). Governments and health-care providers continually seek new ways to be more efficient and to create more effective health service outcomes. This research aims to identify why co-creation will be important in the formulation of future health policy. The project plans to assess patient-centred practi ....Examining the effectiveness of co-creation practices on health outcomes. This projects aims to examine how patients interact collaboratively with multiple stakeholders in a health system (co-creation). Governments and health-care providers continually seek new ways to be more efficient and to create more effective health service outcomes. This research aims to identify why co-creation will be important in the formulation of future health policy. The project plans to assess patient-centred practices using qualitative and quantitative health outcome measures and to model the patient’s end-to-end journey by developing new metrics. The intended outcomes are practical guidelines to help health professionals focus on the most effective co-creation activities and interactions. The research aims to determine how co-creation practices shape a service ecosystem by examining the effectiveness of a patient-centred approach on health care service outcomes. Findings will improve the implementation of health care practices.Read moreRead less
Employee voice in Australia: the impact of employee participation arrangements on organisational performance and employee well-being. Given the extent of union decline in Australia, there is a need to update policy to reflect the new reality of low unionisation. This project will examine what alternative arrangements exist and their economic and social consequences. It focuses on the employee impacts and employer impacts of these arrangements and will inform current policy debates.
Enhancing volunteer capacity to maximise the volunteer resources for contextually diverse community organisations. The study aims to maximise the volunteer resources available to community organisations through the development of a flexible organisational volunteer model that enhances each volunteer's capacity, particularly at key points of their engagement.Individual volunteer capacities will be analysed using a multidimensional measure validated with different volunteer samples across diverse ....Enhancing volunteer capacity to maximise the volunteer resources for contextually diverse community organisations. The study aims to maximise the volunteer resources available to community organisations through the development of a flexible organisational volunteer model that enhances each volunteer's capacity, particularly at key points of their engagement.Individual volunteer capacities will be analysed using a multidimensional measure validated with different volunteer samples across diverse organisations and social contexts. The model will help community organisations determine the self-efficacy of volunteers; enhance individual and collective volunteer capacity;identify new volunteer pathways responsive to the lifestyles and social and economic circumstances of volunteers;and create a more capable and responsive pool of volunteers.Read moreRead less
A dynamic model linking organisational systems to clinical performance in Australian hospitals. With increasing pressure on the hospital sector in Australia and at a time of substantial reform, this project will have a significant impact on performance within Australian hospitals and in turn, the health and wellbeing of the Australian population. This project models the dynamic link between hospital systems and clinical performance.
About time: Climate change adaptation in Australian industries. This project aims to assist the most vulnerable industries in Australia as they adapt to climate change. By investigating the interplay between industry practices and climate impacts, the project proposes to develop a theoretical conceptualization of time. This is significant in addressing the temporal tension between financial short-termism and future climate commitments. The expected outcomes include advancing the scholarly discus ....About time: Climate change adaptation in Australian industries. This project aims to assist the most vulnerable industries in Australia as they adapt to climate change. By investigating the interplay between industry practices and climate impacts, the project proposes to develop a theoretical conceptualization of time. This is significant in addressing the temporal tension between financial short-termism and future climate commitments. The expected outcomes include advancing the scholarly discussion of time and the creation of a practical tool in the form of digital stories that will make sustainable futures actionable. This benefits Australian industries by strengthening their capacity to meet the future challenges of climate change.Read moreRead less
Managing Productive and Collaborative Relations in Australian Workplaces. Concerns over workplace productivity are high on the agenda of policymakers. Evidence suggests that collaboration in the workplace and high involvement approaches have a productivity premium of up to 20 per cent over those without the commitment to collaborative approaches. However, collective relations do not necessarily mean union relations nor necessarily collaborative relations. This research will benefit Australia's s ....Managing Productive and Collaborative Relations in Australian Workplaces. Concerns over workplace productivity are high on the agenda of policymakers. Evidence suggests that collaboration in the workplace and high involvement approaches have a productivity premium of up to 20 per cent over those without the commitment to collaborative approaches. However, collective relations do not necessarily mean union relations nor necessarily collaborative relations. This research will benefit Australia's social and economic fabric through understanding alternative means by which collaborative workplace relations lead to productivity gains. This is consistent with the current policy approach of government in promoting productive and harmonious workplace level industrial relations.Read moreRead less