Why Do People Develop Chronic Low Back Pain? An Investigation Of Brain Function As A Predictor Of Chronic Low Back Pain.
Funder
National Health and Medical Research Council
Funding Amount
$96,631.00
Summary
Chronic low back pain is the most disabling condition worldwide. Two objective measures of brain function, electrical signals of brain activity (electroencephalography), and attentional bias observed with eye tracking technology will be measured in a group of participants with acute back pain. These measurements will provide objective markers of brain function that may be predictive of the transition from acute to chronic low back pain, providing new opportunities for treatment.
An Exploration Of The Mechanisms Underlying A Novel Pain Biology Education Intervention (Explain Pain) In Reducing The Development Of Chronic Low Back Pain
Funder
National Health and Medical Research Council
Funding Amount
$106,057.00
Summary
Chronic low back pain is a massive health problem in Australia. This research will investigate the underlying mechanisms of modulating one’s thoughts and beliefs about their pain via a psychoeducative intervention after an acute episode of low back pain. Exploring the mechanisms of this intervention is a crucial step towards understanding how explaining pain could reduce the development of chronic low back pain from an acute episode of low back pain.
The PRECISE study is a double blind, randomised, placebo controlled trial comparing pregabalin in addition to usual care, to placebo in addition to usual care for the treatment of sciatica.
The Communication Of Acute Postoperative Pain (CAPP):the Clinically Significant Meanings Behind Numerical Pain Ratings
Funder
National Health and Medical Research Council
Funding Amount
$93,742.00
Summary
Between 45% – 80% of patients still have moderate to severe pain after surgery and receive less than 50% of the pain medications available. Using a 0 – 10 pain rating can contribute to this problem because there is no consistent understanding about what the numbers mean or how they should guide pain management decisions. The project aim is to develop a standard approach to using a numerical pain rating to assist patients to report the severity of their pain in ways that assists clinicians to dec ....Between 45% – 80% of patients still have moderate to severe pain after surgery and receive less than 50% of the pain medications available. Using a 0 – 10 pain rating can contribute to this problem because there is no consistent understanding about what the numbers mean or how they should guide pain management decisions. The project aim is to develop a standard approach to using a numerical pain rating to assist patients to report the severity of their pain in ways that assists clinicians to decide the best pain management.Read moreRead less
Low back pain is a major global health problem and the leading cause of disability worldwide . This project will trial a new treatment for back pain that is specifically aimed at risk factors for developing ongoing back problems. Previously shown to be successful in patients suffering persistent back problems, this promising new treatment will be trialled in patients soon after they develop lower back pain as a preventative approach.
The First Randomised Placebo Controlled Trial Of Paracetamol For Acute Low Back Pain
Funder
National Health and Medical Research Council
Funding Amount
$73,852.00
Summary
Low back pain is a considerable burden for individuals and society. While clinical guidelines recommend simple treatments such as paracetamol for new low back pain, most people receive costly and potentially harmful treatments. This may be due to limited direct evidence supporting the recommended treatments. A placebo controlled clinical trial of 1650 patients with recent onset low back pain will be conducted to determine the effect that paracetamol has on improving the time to recovery.
Understanding The Brain In The Transition From Acute To Chronic Low Back Pain
Funder
National Health and Medical Research Council
Funding Amount
$107,049.00
Summary
A critical question in treating low back pain (LBP) is why some people get better after hurting their back while others do not. Physiological mechanisms, such as brain plasticity and central sensitisation, are believed to underpin the transition to persistent pain. This is the first study to evaluate these mechanisms longitudinally and their relationship with LBP outcomes. The result of this research will provide better understanding of pain mechanisms of LBP and assist to develop novel therapy.
Patellofemoral Joint Osteoarthritis: The Effect Of Foot Orthoses
Funder
National Health and Medical Research Council
Funding Amount
$99,002.00
Summary
Despite the burden of patellofemoral joint osteoarthritis (PFJ OA), there is a paucity of evidence for conservative treatments. This project aims to determine the functional features of PFJ OA and develop a clinical tool to enable identification of features associated with PFJ OA. A randomised controlled trial will then be conducted utilising a foot orthoses intervention to determine whether foot orthoses improve function and pain in people with PFJ OA.
Activating Primary Care COPD Patients With Multi-morbidity (APCOM) Pilot Project
Funder
National Health and Medical Research Council
Funding Amount
$78,309.00
Summary
The Activating Primary Care COPD Patients with Multi-morbidity (APCOM) pilot project aims to empower primary care patients with chronic obstructive pulmonary disease and other co-existing chronic conditions. This will be done by means of a tailored, practice nurse-delivered, self-management intervention designed to improve the participants' disease awareness and coping skills.
Individualizing Cytomegalovirus Preventative Strategies Following Solid Organ Transplantation: A Precision Medicine Approach
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Cytomegalovirus (CMV) infection is a significant contributor to poor outcomes following solid organ transplantation. Current preventative strategies are somewhat effective but treat groups of patients similarly rather than targeting the individual, so many patients are treated unnecessarily & breakthrough disease still occurs. We propose a program of research directed towards individualizing CMV prevention strategies in solid organ transplant recipients, incorporating new diagnostic tests.