A Sequential Multiple Assignment Randomised Trial (SMART) Of Nursing Interventions To Reduce Pain Associated With Chemotherapy Induced Peripheral Neuropathy
Funder
National Health and Medical Research Council
Funding Amount
$713,418.00
Summary
Modern chemotherapy treatments can result in damage to the peripheral nerves, resulting in a condition called peripheral neuropathy. This condition is characterised by a range of sensory and functional changes that can cause pain and reduced ability to perform daily activities. This project will test various non-pharmacological pain management measures to determine if they are effective in improving the quality of life of patients who experience this problem.
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
The role of the immune system in pain is emerging from recent discoveries, and may hold the key to novel pain treatments. Most people experience brief gut infections from food or contagion without long-term consequences. Many others suffer symptoms for years afterwards - probably the best example of immune-based pain. Our project investigates how immune cells communicate with sensory nerves, and how these communications change from both angles after gut infection or inflammation.
Transient Receptor Potential Channels (TRPs) As Transducers And Targets In Primary Visceral Afferents
Funder
National Health and Medical Research Council
Funding Amount
$669,130.00
Summary
Transient receptor potential, or TRP channels, are involved in generating many of the sensations we perceive, such as heat, cold, touch and pain. Some TRP channels are specialized to signal pain from visceral organs, which we must investigate if we are to find treatments for visceral pain, which are currently lacking.
Special Research Initiatives - Grant ID: SR0354804
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
ARC Research Network on Degraded Environment Assessment and Remediation. There are over 80,000 contaminated sites in Australia and >750,000,000 hectares of land impacted by soil acidity, sodicity, heavy-metals, nutrients and agricultural chemicals. The research network advances assessment, management and remediation of degraded environments (land, water, and air) through collaboration of the research programs developing sustainable solutions. The collective focus is minimising disposal and impac ....ARC Research Network on Degraded Environment Assessment and Remediation. There are over 80,000 contaminated sites in Australia and >750,000,000 hectares of land impacted by soil acidity, sodicity, heavy-metals, nutrients and agricultural chemicals. The research network advances assessment, management and remediation of degraded environments (land, water, and air) through collaboration of the research programs developing sustainable solutions. The collective focus is minimising disposal and impacts of contaminated soil and wastes, and land remediation. By facilitating communication, the network enhances national and international research coordination, interaction with regulators, end-users, industry, and other stakeholders, achievement of critical mass for new initiatives, enhances research training and contributes to a critical National Priority.Read moreRead less
The Macroderma initiative: conserving ghost bats and informing development. This project aims to improve methods for capturing biological information required for environmental assessments of highly mobile species and enable strategic environmental planning in Northern Australia. Using Australia’s iconic ghost bat as a focus, the project will test and apply emerging technologies to obtain key information on a species’ population status and its critical resources to inform assessments of ecologic ....The Macroderma initiative: conserving ghost bats and informing development. This project aims to improve methods for capturing biological information required for environmental assessments of highly mobile species and enable strategic environmental planning in Northern Australia. Using Australia’s iconic ghost bat as a focus, the project will test and apply emerging technologies to obtain key information on a species’ population status and its critical resources to inform assessments of ecological impacts of industry development. Important benefits of the project include information and tools for streamlining development approvals and accurately assessing risks to threatened species to improve outcomes for both our economy and our natural environment.Read moreRead less
Early warning of cyanobacteria blooms in drinking water reservoirs by means of evolutionary algorithms. Estimated economic cost of cyanobacteria blooms to Australia are at $150 million p.a. Early warning for cyanobacteria blooms will inform water managers to conduct preventive and operational control in reservoirs and water works, and significantly lower risks for public health and costs for monitoring and treatment. Resulting early warning systems will be novel prototypes for cyanobacteria bloo ....Early warning of cyanobacteria blooms in drinking water reservoirs by means of evolutionary algorithms. Estimated economic cost of cyanobacteria blooms to Australia are at $150 million p.a. Early warning for cyanobacteria blooms will inform water managers to conduct preventive and operational control in reservoirs and water works, and significantly lower risks for public health and costs for monitoring and treatment. Resulting early warning systems will be novel prototypes for cyanobacteria blooms in drinking water reservoirs based on forecasting models adaptable to environmental and climate change. Model-based scenario analysis will also assist in informed decisions on effects of drought, injection of recycled water and global warming to cyanobacteria growth.Read moreRead less
A global standard for the status of Wetlands of International Importance. The project will develop and test a new global standard for the assessment and reporting on ecological condition of internationally important wetlands, listed under the Ramsar Convention. It has four aims: establishment of a strategic adaptive management and governance framework, a meta-analysis of the 2,303 internationally listed wetlands, development of a protocol for assessment and prediction and delivering a digital re ....A global standard for the status of Wetlands of International Importance. The project will develop and test a new global standard for the assessment and reporting on ecological condition of internationally important wetlands, listed under the Ramsar Convention. It has four aims: establishment of a strategic adaptive management and governance framework, a meta-analysis of the 2,303 internationally listed wetlands, development of a protocol for assessment and prediction and delivering a digital reporting platform for effective management. The project is significant because it tackles the decline of freshwater ecosystems, by targeting the most prominent wetlands. It also assists state and national governments to meet their obligations under the Ramsar Convention and most importantly guides more effective management.Read moreRead less
Is New Guinea the missing link for understanding Australia’s rainforests? This project aims to understand the extent to which the animals in Australia have shared histories with animals from the islands of Melanesia, and especially New Guinea. Key outcomes will be identification of hotspots of unique and high evolutionary diversity across both regions, and understanding of whether New Guinea has been an overall refuge or source for rainforest animals as Australia became more arid over the last 2 ....Is New Guinea the missing link for understanding Australia’s rainforests? This project aims to understand the extent to which the animals in Australia have shared histories with animals from the islands of Melanesia, and especially New Guinea. Key outcomes will be identification of hotspots of unique and high evolutionary diversity across both regions, and understanding of whether New Guinea has been an overall refuge or source for rainforest animals as Australia became more arid over the last 20 million years. Expected benefits include addressing fundamental gaps in our knowledge of the history of both the Australian continent and its resident biota such as when landbridges first formed with New Guinea, and the identification of priority areas for conservation investment in both Australian and Melanesia.Read moreRead less
Utilising innovative fishing technology to address key questions on the biology of Antarctic krill. Antarctic krill are an important species in the Southern Ocean supporting most of the Antarctic birds and mammals. A sustainable krill fishery is developing with krill products used in aquaculture and increasingly for human consumption. A new omega 3 krill oil industry has emerged and is rapidly expanding. The aim of the project is to predict the factors governing oil levels and the biochemical co ....Utilising innovative fishing technology to address key questions on the biology of Antarctic krill. Antarctic krill are an important species in the Southern Ocean supporting most of the Antarctic birds and mammals. A sustainable krill fishery is developing with krill products used in aquaculture and increasingly for human consumption. A new omega 3 krill oil industry has emerged and is rapidly expanding. The aim of the project is to predict the factors governing oil levels and the biochemical composition in krill which will help us understand growth, reproduction and recruitment. The research aims to also assess the possible effects of climate change on krill. Outcomes of this research aim to be used to manage the expanding krill fishery.Read moreRead less