Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
High Penetrance Deleterious Mutations In Blinding Glaucoma
Funder
National Health and Medical Research Council
Funding Amount
$1,345,055.00
Summary
This project aims to identify the genes most commonly mutated in individuals with advanced glaucoma. Identification of such genes will lead to improved understanding of glaucoma pathogenesis, a better ability to predict risk, and the identification of drug targets for novel therapies.
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
Integrating evolution and plasticity into predictions of population persistence in a changing climate: adaptation or extinction? To effectively manage biodiversity at a time of rapid environmental change, Australia needs accurate predictions of how human alterations to climate and habitat will affect species. This project integrates evolution and spatial ecology to develop new tools for predicting and understanding how species will respond to environmental change.
The basis of oyster resilience to global environmental change. This project aims to investigate the impact of global environmental change on the survival of Australia’s oyster industry, by combining the science of genetics, physiology and ecology to identify already resilient oysters. Through the first complete understanding of resilience in oysters, including the trade-offs they have made in other fitness traits, the project develops new capacities to 'climate and future-proof' our natural oyst ....The basis of oyster resilience to global environmental change. This project aims to investigate the impact of global environmental change on the survival of Australia’s oyster industry, by combining the science of genetics, physiology and ecology to identify already resilient oysters. Through the first complete understanding of resilience in oysters, including the trade-offs they have made in other fitness traits, the project develops new capacities to 'climate and future-proof' our natural oyster populations and the Australian oyster industry, to enable the restoration of degraded oyster habitats. This project will ensure the future of an iconic and economically important national industry and food source and contribute to preserving the critical cultural links of Indigenous Australians with their lands.Read moreRead less
The reliability of corporate reporting of greenhouse gas estimates: Determinants, consequences, training for accountants and policy Initiatives. Fundamental to the successful re-allocation of resources to address climate change is that greenhouse gas estimates reported by firms are reliable. The first outcome from this research is the development of tools to assist and train the Australian accountancy profession in the estimation of reliable emissions. The second outcome is identification of fac ....The reliability of corporate reporting of greenhouse gas estimates: Determinants, consequences, training for accountants and policy Initiatives. Fundamental to the successful re-allocation of resources to address climate change is that greenhouse gas estimates reported by firms are reliable. The first outcome from this research is the development of tools to assist and train the Australian accountancy profession in the estimation of reliable emissions. The second outcome is identification of factors associated with the inaccuracy and bias of greenhouse gas emissions reported by companies and the consequences of the inaccuracies for the share market's valuation of emission liabilities. These research findings will identify issues that need to be addressed by regulators to ensure that the greenhouse gas estimates reported by companies are reliable.Read moreRead less
Peripheral isolates as hotbeds of adaptive diversity. This project uses cutting edge molecular technology and spatial analyses to predict the location of diversity relevant to managing the impact of climate change. Knowledge generated in this project will open the door to the informed use of genetic translocation in efforts to kerb expected biodiversity losses.
Detecting sex differences in natural selection. This project aims to develop new genomic approaches for understanding how genetic mutations can differentially affect reproductive success in males and females. Applying novel tests, this project aims to uncover previously hidden genetic conflicts between the sexes. This will provide significant benefits, such as new tools that will be broadly applicable to the wider research community, and help to answer key questions in genetics and evolutionary ....Detecting sex differences in natural selection. This project aims to develop new genomic approaches for understanding how genetic mutations can differentially affect reproductive success in males and females. Applying novel tests, this project aims to uncover previously hidden genetic conflicts between the sexes. This will provide significant benefits, such as new tools that will be broadly applicable to the wider research community, and help to answer key questions in genetics and evolutionary biology in the current genomic era.Read moreRead less
Towards 2050 - managing recovery of Australia's coral reefs. The coral reefs of Australia contribute over $6 bn each year to the economy. However, the reefs of Australia, in addition to those worldwide, are threatened by coral bleaching driven by anthropogenic climate change. If we are to preserve the economic, social and ecosystem value of these environments, it is essential that we are able to better manage the recovery of reefs from bleaching events. This project will utilise a variety of mul ....Towards 2050 - managing recovery of Australia's coral reefs. The coral reefs of Australia contribute over $6 bn each year to the economy. However, the reefs of Australia, in addition to those worldwide, are threatened by coral bleaching driven by anthropogenic climate change. If we are to preserve the economic, social and ecosystem value of these environments, it is essential that we are able to better manage the recovery of reefs from bleaching events. This project will utilise a variety of multi-disciplinary approaches, ranging from future climate models, historical satellite data to in-field experimentation to fill fundamental knowledge gaps in our understanding of coral bleaching recovery and delivery a variety of management and stakeholder relevant outputs.Read moreRead less
Diversity maintenance in patchy environments. This project aims to advance understanding of species coexistence and diversity maintenance in complex natural environments. Though diversity varies across patchy natural and human-created environments, the mechanistic drivers of these patterns remain poorly understood. This knowledge gap limits our ability to predict and manage responses of natural communities to environmental changes. Using data from threatened Western Australian wildflower communi ....Diversity maintenance in patchy environments. This project aims to advance understanding of species coexistence and diversity maintenance in complex natural environments. Though diversity varies across patchy natural and human-created environments, the mechanistic drivers of these patterns remain poorly understood. This knowledge gap limits our ability to predict and manage responses of natural communities to environmental changes. Using data from threatened Western Australian wildflower communities and novel ecological models of species coexistence, the project aims to deliver a mechanistic understanding of biological diversity, and provide fundamental knowledge needed to improve ecosystem management and restoration outcomes across Australia and globally.Read moreRead less