Risk Assessment And Prevention Of Respiratory Complications In Paediatric Anaesthesia
Funder
National Health and Medical Research Council
Funding Amount
$494,253.00
Summary
Respiratory problems account for more than three quarters of all critical incidents and a third of all cardiac arrests in healthy children undergoing anaesthesia for surgical procedures. It is therefore vital to identify high risk children early to be able to adapt the anaesthesia regimen accordingly. This series of studies will study new prediction and prevention strategies to minimise respiratory problems and therefore improve the safety for our children when undergoing anaesthesia.
Neurodevelopmental Outcome After Sevoflurane Versus Dexmedetomidine/remifentanil Anaesthesia In Infancy: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$825,787.00
Summary
Evidence in animals show that some anaesthetics affect the developing brain. Some human data also show a link between childhood surgery and poorer neurodevelopmental outcome. It is unknown if this association is due to the anaesthetic. Our recent GAS trial showed no evidence for toxicity after 1 hour of anaesthesic but many children have longer anaesthetics. We plan to enrol 420 infants in a study comparing neurodevelopmental outcome after 2 different anaesthetics for surgery lasting >2 hours ....Evidence in animals show that some anaesthetics affect the developing brain. Some human data also show a link between childhood surgery and poorer neurodevelopmental outcome. It is unknown if this association is due to the anaesthetic. Our recent GAS trial showed no evidence for toxicity after 1 hour of anaesthesic but many children have longer anaesthetics. We plan to enrol 420 infants in a study comparing neurodevelopmental outcome after 2 different anaesthetics for surgery lasting >2 hours.Read moreRead less
Population Prevalence And Environmental-genetic Predictors Of Food Allergy In An Infant Cohort
Funder
National Health and Medical Research Council
Funding Amount
$551,642.00
Summary
This study will measure which children are at greatest risk of food allergy. We plan to recruit 5000 children to test for food allergies, as well as asking a range of questions on different lifestyle factors such as diet and history of allergies . If positive, participants will be invited to a hospital clinic for tests and treatment. This will allow us to describe the epidemiology of food allergy, and assist the development of better services for those with food allergy in the community.
IL-16 Regulates Mast Cell Chemotaxis And Function Through The Tetraspanin CD9.
Funder
National Health and Medical Research Council
Funding Amount
$465,750.00
Summary
Mast cells are found in humans and other mammals at strategic sites such as skin, lining of the airways and gut and provide a first line of defence against a variety of infections. These cells use a number of products that have profound effects in humans. In particular, these products are thought to be involved in defence against bacteria, viruses and are implicated in allergic conditions such as asthma. In normal circumstances mast cells are only found in the tissues and not in the peripheral b ....Mast cells are found in humans and other mammals at strategic sites such as skin, lining of the airways and gut and provide a first line of defence against a variety of infections. These cells use a number of products that have profound effects in humans. In particular, these products are thought to be involved in defence against bacteria, viruses and are implicated in allergic conditions such as asthma. In normal circumstances mast cells are only found in the tissues and not in the peripheral blood. However, we have made the first observation that mast-like cells occur in the peripheral blood of patients with asthma and allergic conditions but not in normals. This finding changed the prevailing paradigm for mast cell biology. The products that can influence mast cell growth and function are vital to the understanding of how mast cells are involved in conditions such as human asthma. We have demonstrated that a protein (CD9) on mast cells in the tetraspanin family is a receptor for a product (IL-16) which is thought to be important in asthma and other inflammatory conditions. The understanding of how mast cells are regulated by IL-16 may lead to potential new therapies in conditions such as asthma and HIV-1 infection.Read moreRead less