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Domiciliary Oxygen Therapy In Interstitial Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$124,608.00
Summary
Interstitial lung diseases (ILD) are chronic lung diseases with significant health impacts, but limited drug treatment options. Although home oxygen treatment (HOT) is commonly used in these patients, its clinical benefits are uncertain with potential risks and significant costs for both patients and the health care system. Very little published information is available on the use of HOT in these patients. These studies aim to improve our knowledge and management of HOT in patients with ILD.
Assessing And Optimising Anti-Cancer Drug Utilisation
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Cancer is increasingly common in Australia and often treated with expensive drugs tested in idealised settings within clinical trials. It is vital to collect real world data about how cancer treatments are used in Australia. This research will use routinely collected health care data to determine how anti-cancer drugs are used in the real world, how effective they are in treating cancer, and identify areas for improvement to promote effe ctive, appropriate and equitable use of anti-cancer drugs.
Ambulance demand is increasing internationally and has been associated with poorer patient outcomes. Although little is known about the drivers of demand, ambulance services are implementing revised telephone triage models to divert critical resources away from patients with non-urgent complaints. This research aims to evaluate ambulance demand, as well as the safety and effectiveness of revising telephone triage and ambulance dispatch models.
Do The Mitochondrial Sirtuin Enzymes, SIRT3 And SIRT5, Affect Insulin Action In Skeletal Muscle?
Funder
National Health and Medical Research Council
Funding Amount
$92,314.00
Summary
Metabolic disorders such as obesity, insulin resistance and type 2 diabetes are characterised by inappropriate handling of nutrients. Mitochondria are the primary site for nutrient oxidation in cells. Sirtuins such as SIRT3 and SIRT5 are abundant in mitochondria and may affect mitochondrial function and insulin action in skeletal muscle. Understanding the biochemical pathways involved in energy metabolism in skeletal muscle is crucial in the development of therapies for insulin resistance and ty ....Metabolic disorders such as obesity, insulin resistance and type 2 diabetes are characterised by inappropriate handling of nutrients. Mitochondria are the primary site for nutrient oxidation in cells. Sirtuins such as SIRT3 and SIRT5 are abundant in mitochondria and may affect mitochondrial function and insulin action in skeletal muscle. Understanding the biochemical pathways involved in energy metabolism in skeletal muscle is crucial in the development of therapies for insulin resistance and type 2 diabetes.Read moreRead less
This project will examine if providing additional therapy services on a Saturday reduces health care costs, and improves the health of hospital inpatients receiving rehabilitation compared to the usual Monday to Friday service. Preliminary information suggests additional Saturday rehabilitation services could reduce length of stay by 3 days without compromising discharge outcomes. If successful this trial will have substantial health and economic benefits for the patients and for organizations.
Personality disorders are serious psychiatric disorders. Despite this, the prevalence of these disorders in the Australian community is largely unknown, as is their influence on physical and other mental health conditions and impact on Australia’s medical and mental health care services. This epidemiological study will answer these questions, with the aim of informing public health planning and service delivery practices and prompting future health economic research in this area.
Accelerated Telomere Length Attrition Rate In Diabetes And Its Cellular Mechanism
Funder
National Health and Medical Research Council
Funding Amount
$38,381.00
Summary
I am a PhD in Medicine-University of Sydney. My research focus is about telomere dynamic, its mechanism and correlation between telomere length and diabetes attributes. I will compare telomere length between different diabetes groups & examine telomere regulation in cell culture/animal model to compliment my clinical data. The hypothesis: accelerated telomere shortening may co-segregate with diabetes complications and by preserving telomere we could potentially prevent adverse effect of diabetes
The Role Of Redox Regulation In Controlling The Oncogenic Function Of Eph Receptors
Funder
National Health and Medical Research Council
Funding Amount
$71,766.00
Summary
Reactive oxygen species (ROS) produced in cancers activate cell surface receptor signalling pathways that drive cancer progression. I will study links between ROS and receptor signalling in cancer cells, and inhibit signalling with ROS scavengers delivered in nanoparticles, targeted to receptor complexes with specific antibodies. These will include antibodies we raised against ADAM10, a protease associated with multiple receptor signalling pathways, to simultaneously inhibit these pathways.
A Geographic Approach To Measuring Social Deprivation And Health Care Need For Primary Health Care Policy And Planning
Funder
National Health and Medical Research Council
Funding Amount
$148,213.00
Summary
Understanding how and where people use and access health services, and how social disadvantage affects this is important for planning and providing primary health care services. Presenting information as maps is an effective way to explore and communicate these issues. This research program will use a geographic and map-based approach to understanding patterns of health service use and social disadvantage, to assist in developing primary health care policy.
Evaluating A Program For Developing Specialist Cancer Nurse Competencies For Effective And Sustainable Self-management Of Dyspnoea In Lung Cancer Patients.
Funder
National Health and Medical Research Council
Funding Amount
$123,143.00
Summary
Breathlessness is a common, distressing symptom of lung cancer and adds substantially to the disease burden. This study aims to develop and evaluate a specialist cancer nurse competencies program to support patients in breathlessness self-management strategies. This study will assume a key role in instituting person-centred models of integrated cancer service delivery in adding to the limited knowledge about what skills and abilities are required of nurses to support patient self-management.???