Mitochondrial Dysfunction In Cardiac Hypertrophy And Failure
Funder
National Health and Medical Research Council
Funding Amount
$164,821.00
Summary
Heart failure is a disease of wide prevalence in the Western World. In addition to the human toll of heart failure, the economic impact is highly substantial. It remains unclear what causes heart failure, but the effects of calcium and free radicals produced in the mitochondria on muscle function are generally accepted as major contributors. The aim of this project is to understand how calcium and free radicals interact with each other and the mechanisms by which they reduce heart function.