Reducing Global Mortality And Severity Of Disease In Newborn Infants Through Innovation And Holistic Interventions
Funder
National Health and Medical Research Council
Funding Amount
$2,060,520.00
Summary
Infants born prematurely often encounter problems affecting the growth, development and function of multiple body systems. This multi-organ disease usually results from infection, inflammation, and excessive or insufficient oxygen. Importantly, many premature infants are born in low-resource settings. This fellowship aims to reduce global mortality and multi-organ disease in preterm infants using simple, holistic and low-cost interventions that directly target the underlying causative factors.
Early Life Exposures And Chronic Disease: Mechanisms And Preventative Strategies
Funder
National Health and Medical Research Council
Funding Amount
$2,714,215.00
Summary
The world is in the grips of an epidemic of chronic disease and exposure to pollution in early life is partly responsible. To change this situation we need to understand and mitigate the mechanisms linking early life pollution exposure to life-long disease risk. My research will provide direct evidence of how pollution increases disease risk and design and implement strategies to reduce this, with an emphasis on asthma, cystic fibrosis and chronic respiratory disease.
IRON IN DISEASES OF THE AGEING BRAIN: From Bench To Clinic
Funder
National Health and Medical Research Council
Funding Amount
$1,814,215.00
Summary
I aim to achieve a deeper understanding of the causes, detection and treatment of incurable neurological diseases of advancing age - Alzheimer’s disease, Parkinson’s disease and Motor Neuron Disease. Iron needlessly accumulates in brain tissue with age. I will pursue studies of ageing worms, cells in culture, mice, human brain tissue, brain imaging and clinical trials, to determine whether the problem of iron accumulation is a drug target for these diseases.