The Australian Research Data Commons (ARDC) invites you to participate in a short survey about your
interaction with the ARDC and use of our national research infrastructure and services. The survey will take
approximately 5 minutes and is anonymous. It’s open to anyone who uses our digital research infrastructure
services including Reasearch Link Australia.
We will use the information you provide to improve the national research infrastructure and services we
deliver and to report on user satisfaction to the Australian Government’s National Collaborative Research
Infrastructure Strategy (NCRIS) program.
Please take a few minutes to provide your input. The survey closes COB Friday 29 May 2026.
Complete the 5 min survey now by clicking on the link below.
Role Of AMPK Signaling In Metabolic Control During Exercise
Funder
National Health and Medical Research Council
Funding Amount
$566,288.00
Summary
It is well recognized that sedentary life styles are associated with increased incidence of obesity, Type 2 diabetes and atherosclerotic cardiovascular disease. The medical, social and financial costs of these diseases are growing rapidly and represent a major health care challenge. Exercise is beneficial for maintaining health in patients at risk of developing these diseases and for this reason we are interested in understanding how exercise capacity is regulated.
Supporting A Friend: The Role Of The Molecular Scaffold CoREST Family In Chromatin Regulation And Neuroprotection
Funder
National Health and Medical Research Council
Funding Amount
$354,802.00
Summary
In diseases such as Alzheimer’s disease, Parkinson’s disease and motor neuron disease, neurons degenerate and die. One contributing factor to neuronal death is inflammation. The aim of this study is to identify mechanisms that protect neurons from death. This project focuses on the role of a family of proteins (CoREST1-3) that function to reverse gene expression changes in inflammation that lead to neurodegeneration.
Snakebite is a worldwide health problem, causing some 100,000 deaths per year. We have preliminary evidence that application of nitric oxide-releasing chemical to the skin presents a novel approach to first aid treatment of venomous bites. The method has the advantage of being simple and reliable and could save lives applied by itself or as an adjunct to pressure bandaging with immobilisation (PBI).
Investigating The Cause And Consequences Of Iron Deposition In Parkinson's Disease
Funder
National Health and Medical Research Council
Funding Amount
$459,347.00
Summary
It is known that iron elevation occurs in the brain in Parkinson’s disease. This might cause cell death by ‘rusting’. It is not known (1) how iron accumulates in the disease, (2) whether iron accumulation contributes to the worsening of the disease and (3) if lowering iron with a drug would improve symptoms. We plan to address these questions using a clinical cohort of patients, and laboratory animal models.
Targeting Microvascular Dysfunction In Severe Malaria
Funder
National Health and Medical Research Council
Funding Amount
$871,923.00
Summary
In severe malaria blood vessels cannot make enough protective nitric oxide (NO). The gel-like lining of blood vessels (glycocalyx) is needed to produce NO, but this is damaged in some severe infections. We will test whether glycocalyx is lost in malaria and how it affects blood vessel NO and function in human volunteer infections and in patients with and without severe malaria. We will test whether a salt nitrite, can be used to safely increase NO and blood vessel function in severe malaria.
Nitrate: Studies Of Metabolism And Effects On Blood Pressure
Funder
National Health and Medical Research Council
Funding Amount
$406,275.00
Summary
We propose that dietary inorganic nitrate can lower blood pressure in hypertensive men and women. Two studies will be performed to investigate the potential for an increase in nitrate intake to benefit blood pressure in hypertensive men and women. Nitrate is derived mainly from green leafy vegetables. Hypertension is the leading risk factor for total mortality. Promoting increased intake of nitrate rich green leafy vegetables could have a significant impact on cardiovascular health.
The Physiological Role Of Glutathione-S-Transferase In The Intracellular Storage And Transport Of Nitric Oxide And Its Biomedical Effects
Funder
National Health and Medical Research Council
Funding Amount
$544,839.00
Summary
The aim of this project is to elucidate the mechanisms behind the intracellular regulation of nitrogen monoxide (NO) levels, which has broad implications for understanding NO activity in many processes which have major vital health implications, including the cytotoxic of macrophages and the control of blood pressure.
Nitric Oxide On Cardio Pulmonary Bypass In Congenital Heart Disease
Funder
National Health and Medical Research Council
Funding Amount
$1,878,889.00
Summary
Children undergoing open heart surgery on a heart lung machine can experience serious side effects from the exposure to the artificial circulation during surgery and may have either prolonged need for life support in intensive care or even may suffer from long term complications. In this study we investigate the use of a new approach using nitric oxide, a anti-inflammatory gas, during surgery to reduce these side effects.
The Effect Of Asthma Control During Pregnancy On Markers Of Airways Inflammation And Lung Function In The Offspring
Funder
National Health and Medical Research Council
Funding Amount
$1,131,043.00
Summary
Asthma is the most common chronic disease complication during pregnancy. By improving asthma management we have reduced asthma exacerbations by 50% during pregnancy and their babies suffered less often from bronchiolitis in the first year of life, which can be a life threatening infection. As bronchiolitis also promotes the development of asthma we want to investigate whether better asthma management in pregnancy leads to less lung inflammation and better lung function in the children.
The health benefits of consuming fruits and vegetables can in part be attributed to their high content of polyphenolic compounds such as flavonoids. These substances can improve functioning of blood vessels and have the potential to reduce the risk of heart disease. This project will examine one of the most common flavonoids in the diet to try and understand how it works and better understand the protective effects.