Progesterone Receptor-mediated Coordination Of Oocyte-oviduct Communication During Ovulation
Funder
National Health and Medical Research Council
Funding Amount
$86,128.00
Summary
Infertility affects 1 in 6 couples, often due to failed release of an egg from the ovary. The hormone progesterone is essential for this process. Our goal is to determine how progesterone signals the egg to ensure its correct release into the oviduct where fertilization may occur. To identify these signals, experiments will analyse ovary cells and eggs of mice, including mice that do not respond to progesterone. The results will provide much needed information about female reproductive health.
Adrenal Cushings:natural History And Genetic Analysis Of Inherited Forms, And Prevalence In High Risk Groups.
Funder
National Health and Medical Research Council
Funding Amount
$100,381.00
Summary
This study aims to diagnose early Cushing's in certain high risk groups - before debilitating complications have developed which increase mortality. Early treatment normalises life expectancy and improves quality of life. We aim to discover the genetic cause of inherited Cushing's. This will allow a genetic test to be developed - so gene carriers can be carefully followed for onset of symptoms of Cushing's and those who are not carriers can be reassured.