Production Of Humanised Mouse Models For Haemoglobin E And 0-thalassaemia
Funder
National Health and Medical Research Council
Funding Amount
$280,693.00
Summary
The proposed study aims to identify and characterise genes critical to male fertility using two mouse models of infertility: 1) Joey mouse line: an ENU induced model of sperm abnormalities. Following linkage analysis, candidate genes will be selected for sequencing to identify the causal mutation. 2) Ggn knockout mice. The role of the testis-specific gene, Ggn will be characterised through a phenotypic analysis of Ggn knockout mice and a series of expression and biochemical analyses. Both models ....The proposed study aims to identify and characterise genes critical to male fertility using two mouse models of infertility: 1) Joey mouse line: an ENU induced model of sperm abnormalities. Following linkage analysis, candidate genes will be selected for sequencing to identify the causal mutation. 2) Ggn knockout mice. The role of the testis-specific gene, Ggn will be characterised through a phenotypic analysis of Ggn knockout mice and a series of expression and biochemical analyses. Both models will be of direct value in the identification of commercially relevant contraceptive targets, as well as furthering our understanding of male reproductive function.Read moreRead less
Bisphosphonate Use, Oral Flora, Saliva, Gingival Crevicular Fluid And Bone Markers In Patients With Jaw Osteonecrosis
Funder
National Health and Medical Research Council
Funding Amount
$121,751.00
Summary
Bisphosphonates are used in patients with bones that break easily due to conditions such as osteoporosis. Recent research suggests a possible association between these drugs and jaw bone breakdown called jaw osteonecrosis - a devastating condition with no current effective treatment. It is unclear why this condition affects only jaw bones. This study seeks to investigate if bacteria in the mouth, gum disease and saliva are involved in jaw osteonecrosis, which can then help to improve management.
The CCRE for Oral Health will focus on the prevention and treatment of oral diseases and disorders and their clinical consequences. Research will emphasise three areas of clinical care that are critical to the management of oral health, systemic health and general well-being: 1.Primary prevention to prevent disease onset 2. Diagnosis and risk prediction for oral conditions 3. Clinical intervention
Caries Initiation Across Childhood To Adulthood By Exposure To Water Fluoridation
Funder
National Health and Medical Research Council
Funding Amount
$198,297.00
Summary
This research program is expected to contribute to filling significant gaps in the understanding of factors determining the oral health of Australian children and young adults. The purpose of the project is to develop a better understanding of the outcome of long-term exposure to fluoridated water among young adults.
The Australian Longitudinal Study Of Health And Relationships
Funder
National Health and Medical Research Council
Funding Amount
$2,292,187.00
Summary
Achieving satisfaction in our intimate relationships is a vital component of our well being. To date, most studies of sexual and reproductive health have focused on how common particular problems might be. Thus, studies have tended to have relatively narrow focuses on, for example, the prevalence of pregnancy, miscarriage and termination, or on patterns of sexual practice and contraceptive use, or on the frequency with which individuals experience sexual difficulties. Yet, all of these are inter ....Achieving satisfaction in our intimate relationships is a vital component of our well being. To date, most studies of sexual and reproductive health have focused on how common particular problems might be. Thus, studies have tended to have relatively narrow focuses on, for example, the prevalence of pregnancy, miscarriage and termination, or on patterns of sexual practice and contraceptive use, or on the frequency with which individuals experience sexual difficulties. Yet, all of these are inter-related aspects of sexual and reproductive health that can have profound impacts on each other. Importantly, most of these studies have looked at these issues at a single point in time and could only infer the likely contribution of prior events on currently observed patterns. This study will recruit a random sample of Australians aged 16 to 65 years and interview them annually, initially over a four-year period. It will collect detailed information about sexual and reproductive health and provide essential information about how sexual and reproductive health changes as we age. It will document the relationships between patterns of sexual behaviour, contraceptive choices, pregnancy and its outcomes, and sexual functioning including the experience of sexual problems and the achievement of satisfaction in our physical and emotional intimate relationships.Read moreRead less
The Australian Longitudinal Study Of Health And Relationships
Funder
National Health and Medical Research Council
Funding Amount
$1,624,798.00
Summary
Ensuring the sexual and reproductive health of the Australian population is essential for our wellbeing as a nation. As well as the overall importance, at least three aspects of sexual and reproductive health are among the key policy issues for present Australian governments: maintaining and increasing the birth rate; reducing the abortion rate; and preventing and controlling Chlamydia infections.
The South Australian Dental Longitudinal Study has been the first comprehensive dental longitudinal study of older adults to be conducted in Australia. Participants were aged 60+ years at the 1991 baseline data collection, and were a random sample of community-dwelling older adults in urban Adelaide and rural Mount Gambier. The 11-year follow-up data collection will build upon the previous study findings to provide important and new information about the onset and progression of oral diseases in ....The South Australian Dental Longitudinal Study has been the first comprehensive dental longitudinal study of older adults to be conducted in Australia. Participants were aged 60+ years at the 1991 baseline data collection, and were a random sample of community-dwelling older adults in urban Adelaide and rural Mount Gambier. The 11-year follow-up data collection will build upon the previous study findings to provide important and new information about the onset and progression of oral diseases in older Australians. It will also assist with the identification of general health and other characteristics (socio-demographic, medical, functional, cognitive, nutritional, swallowing, dental history, oral hygiene care, financial, social support and oral disorder social impact characteristics) that are associated with oral diseases in various groups of older adults. Groups of older adults within the study include those who are healthy and living in the community, those who are frail and use support services, and those who have moved into residential care. This information will assist both private and public health sectors, dental professionals and other health professionals with the identification of those older adults who are at high risk for developing oral diseases, such as those with dementia, those with physical disabilities, and those living in residential care. This 11-year data collection will be one of only 4 similar international studies currently being conducted, and will provide important comparison data for future studies of older Australians.Read moreRead less
Squamous Cell Carcinomas Of The Head And Neck: Exploring The Role Of Human Papillomavirus Infection
Funder
National Health and Medical Research Council
Funding Amount
$217,213.00
Summary
Human papillomavirus (HPV) is the major cause of cervical cancer and the cause of 5% of all human cancers. HPV has recently also been associated with oral cancer, especially in patients younger than 50 years of age. In this project we will investigate how common HPV infection is in oral cancers in Australia. In these patients we will also investigate mutations in genes that have been found to play a critical role to clear persistent HPV infections and how cells respond to HPV infection.