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Roles Of Cascades Of Transforming Growth Factor-beta And Matrix Metalloproteinases In The Impact Of Cancer Stem Cells On The Neoplasm Formation Of Oral Squamous Cell Carcinoma.
Funder
National Health and Medical Research Council
Funding Amount
$81,793.00
Summary
Failure of treatment of oral cancer patients is because the specific cancer cells escape from chemo-radiotherapy. These cells feature self-renew and fast growth, which are called cancer stem cells (CSC). We will test our hypothesis “the genes of TGF-?1 and MMP initiate CSCs” using our cell-mouse models to arrest cancer progression, and verify the impact of CSC on cancer formation. This study is critical to know how to arrest CSC and offer an opportunity to develop a targeted anti-cancer therapy.
An Investigation Of Dietary Patterns And Transitions In Disadvantaged Australian Preschool Children: A Birth Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$86,117.00
Summary
The current proposal explores the time of introduction of sugary foods/drinks, their longitudinal trajectory pattern, and their relationship to dental decay and overweight and/or obesity in disadvantaged Australian preschool children (from birth to age 3 years). It uses advanced research methods such as systematic reviews, longitudinal trajectory statistical analysis and structural equation modelling analysis.
Oral Cancer is a devastating disease that is associated with poor survival and greatly impacts the lives who do survive. This project aims to develop a tool to inspect the changes of molecules called microRNAs, in saliva and skin cells of the mouth, collected using a simple, painless method, which will help to predict the risk of patients developing oral cancer.
Dental caries (decay) is a significant early childhood chronic disease in Australia, mainly affecting disadvantaged communities and adversely impacting physical, social and emotional wellbeing. This PhD is nested within the VicGen birth cohort, following influences on tooth decay of 450 infants to age 7. This mixed-methods study will examine the relationship between early childhood caries and obesity, exploring caregivers’ views on these factors and translation to policy and practice.
A Comprehensive Approach To Solutions For Child Oral Health, Wellbeing And Development
Funder
National Health and Medical Research Council
Funding Amount
$100,946.00
Summary
Tooth decay in young children is one of the most common chronic diseases of early childhood. The VicGen birth cohort study has been following more than 400 children, since birth, to look at a range of factors that influence the development of tooth decay. This PhD will use data from the cohort and be one of the first studies to look at the health of children’s teeth between birth and five years of age. Findings from this work will inform strategies to help prevent children developing tooth decay
Chronic Oral Graft-versus-host Disease: Clinical Risk Factors, Biochemical Markers Of Disease Activity And Novel Therapeutics
Funder
National Health and Medical Research Council
Funding Amount
$134,184.00
Summary
Chronic graft-versus-host disease (GVHD) is a serious complication of bone marrow transplantation. The oral cavity is often affected. Aims: 1.Identify and validate risk factors for oral GVHD 2.Assess if specific salivary components reflect disease activity 3.Trial novel therapeutic for GVHD-associated dry mouth Saliva testing may offer a non-invasive method to monitor oral GVHD. Also, new and effective topical agents are greatly needed and will improve therapeutic options in oral GVHD
Investigation Into Oral Cancer In Non-drinking And Non-smoking Females
Funder
National Health and Medical Research Council
Funding Amount
$109,358.00
Summary
There has been an increase incidence of oral cancer in female non-drinkers, non-smokers. The five year survival following diagnosis can be as low as 15-50% as most cancers are advanced at the time of discovery.Precancerous and cancerous oral lesions may mimic any number of benign oral lesions, and as such may be left without investigation and treatment until well advanced. Further investigations into the cause of oral cancer other than smoking and alcohol will aid in management.
Public Health Nutrition Policy: Potential To Influence Parental Food And Drink Choices For 0-2 Year Old Children Equitably
Funder
National Health and Medical Research Council
Funding Amount
$78,044.00
Summary
This study investigates whether Australian public health nutrition policies effectively promote healthy eating among 0-2 year olds. It evaluates whether policies: address key influences on food and drink choices identified by parents; address current consumption patterns; can be applied equitably to reduce socio-economic differences. Evidenced-based recommendations will be made for policy to promote healthy eating effectively and equitably and to ultimately promote healthy weight and oral health ....This study investigates whether Australian public health nutrition policies effectively promote healthy eating among 0-2 year olds. It evaluates whether policies: address key influences on food and drink choices identified by parents; address current consumption patterns; can be applied equitably to reduce socio-economic differences. Evidenced-based recommendations will be made for policy to promote healthy eating effectively and equitably and to ultimately promote healthy weight and oral health.Read moreRead less
Exploiting Genetic Analysis To Predict Response And To Discover Novel Molecular Targeted Therapies For Rectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$83,871.00
Summary
Bowel cancer is a significant health burden in Australia. Currently it is difficult to predict which bowel cancer will shrink with standard therapy (chemoradiotherapy). Similarly, patients whose cancer remain the same or increase in size during treatment, there are no other new options available to them. In this research, I intend to find a model that could predict patient’s treatment pathway and identify alternative therapy for patients who did not respond to standard therapy.
Determining The Genetic Basis Of Skeletal Dysplasias Using Next Generation Sequencing
Funder
National Health and Medical Research Council
Funding Amount
$110,068.00
Summary
Osteoporosis is a common condition in Australia, yet treatment options are still limited. Study of rare genetic bone conditions known collectively as skeletal dysplasias have already led to the development of two new osteoporosis drug treatments. My project aims to identify the causative gene for several skeletal dysplasias, and to determine how these genes are involved in the development and maintenance of bone. This knowledge may then translate into new osteoporosis therapies.