Harnessing Tyrosine Metabolism To Combat Respiratory Diseases
Funder
National Health and Medical Research Council
Funding Amount
$866,467.00
Summary
Cross-talk between our immune system and the microbiome is central to health and disease. In particular, the gut microbiome has wide-ranging effects throughout the body, in part through the production of metabolites with immunomodulatory activity. We have discovered a novel subset of microbial metabolites which can protect mice against allergic airway inflammation, a model of asthma. We now aim to discovery how these metabolites work with a view towards developing them as therapeutics.
Once treatable infections are becoming deadly because bacteria are developing broad antibiotic resistance. New medicines are urgently needed. Microbes themselves are the richest known source of new antibiotics but finding the 'good bugs' is like finding a needle in a microbial haystack. This project will use state-of-the art science to screen a previously overlooked source of rich microbial biodiversity and find new antibiotics.
Genomic Approaches To Understand And Control The Emergence Of Vancomycin Resistant Enterococcus Faecium (VREfm) In Australia.
Funder
National Health and Medical Research Council
Funding Amount
$756,163.00
Summary
VRE is a serious hospital superbug that has been increasing in many major hospitals around Australia, while at the same time MRSA (Golden Staph) infections have been decreasing. This project will find out why VRE is increasing by examining what happens to patients at a major Australian hospital from their time of admission to the onset of infection with VRE. At the end of the project we will have the first real understanding of how VRE is transmitted so we can develop effective infection control ....VRE is a serious hospital superbug that has been increasing in many major hospitals around Australia, while at the same time MRSA (Golden Staph) infections have been decreasing. This project will find out why VRE is increasing by examining what happens to patients at a major Australian hospital from their time of admission to the onset of infection with VRE. At the end of the project we will have the first real understanding of how VRE is transmitted so we can develop effective infection control measures.Read moreRead less
Host Cell Death Signaling And Susceptibility To Bacterial Gut Infection
Funder
National Health and Medical Research Council
Funding Amount
$682,321.00
Summary
Bacterial infections are a major cause of infectious disease worldwide. Here we aim to characterise immune responses that help fight infection by E. coli and Salmonella. These bacteria have evolved ways to shut down many of our immune responses during infection, allowing them to survive and cause disease. This work will help understand the complex relationship between gut bacteria and our immune system and provide solutions for controlling infection and treating immune disorders of the gut.
Molecular Basis For The Emergence Of Community Acquired Staphylococcus Aureus
Funder
National Health and Medical Research Council
Funding Amount
$427,518.00
Summary
Golden Staph is a major problem in our hospitals but serious Golden Staph infections are increasingly common in the community, among otherwise healthy people who have had no contact with hospitals. This project will find out how Golden Staph is evolving to become more likely to cause disease in the community. This knowledge can then be used to design new strategies for early detection, prevention and treatment.
Population Health Planning For Rural Medicare Locals: Evaluating A Community Participation Method For Delivering Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$438,587.00
Summary
The study, in six communities, will evaluate whether an evidenced based method of rural community participation from the UK translates to assist healthcare planning by Medicare Locals. Medicare Locals must involve local people in designing services to improve health, but lack methods to do this. The focus of the study is oral health, a major issue in rural areas. The study evaluates whether new services are designed and implemented and whether there is change to health knowledge and behaviours.
New methodologies for representing and accessing resources on endangered languages: a case study from South Efate. Linguists produce material which has immense cultural significance as it is often the only record of endangered cultures. With new technologies come new ways of working with indigenous languages. This APD will develop an innovative methodology for documenting and archiving data from a language of the Pacific. It will do this by linking a dictionary, texts, audio, video, images and a ....New methodologies for representing and accessing resources on endangered languages: a case study from South Efate. Linguists produce material which has immense cultural significance as it is often the only record of endangered cultures. With new technologies come new ways of working with indigenous languages. This APD will develop an innovative methodology for documenting and archiving data from a language of the Pacific. It will do this by linking a dictionary, texts, audio, video, images and a grammar to facilitate presentation of both the data and its analysis to speakers, fellow linguists, and the general public. The methodology developed in this APD will result in innovative linguistic data management techniques conformant to emerging international standards.Read moreRead less
Oral Tradition, Literacy and Education in Two Eastern Indonesian Societies. This project will improve our understanding of social and cultural change in eastern Indonesia, a region of strategic importance to Australia. The research will contribute significantly to knowledge of the educational system and literacy levels in eastern Indonesia. This knowledge will be of practical use in development projects in the region and to policy makers in Canberra who are concerned with Indonesian affairs. The ....Oral Tradition, Literacy and Education in Two Eastern Indonesian Societies. This project will improve our understanding of social and cultural change in eastern Indonesia, a region of strategic importance to Australia. The research will contribute significantly to knowledge of the educational system and literacy levels in eastern Indonesia. This knowledge will be of practical use in development projects in the region and to policy makers in Canberra who are concerned with Indonesian affairs. The involvement of a PhD student in the project will increase our national research capacity in eastern Indonesia. The contributions to anthropological theory and method this research will produce will enhance Australia's international reputation as a centre of anthropology, southeast Asian studies and the study of literacy.Read moreRead less