Towards An Understanding Of Dynamic Genetic Regulation At A Global Scale In Bacteria: A Systems Biology Approach
Funder
National Health and Medical Research Council
Funding Amount
$486,000.00
Summary
To achieve major breakthroughs in the understanding of the regulation of gene transcription in bacteria at a global scale. High throughput technologies (living cell arrays, tiling DNA microarrays, multidimensional liquid chromatography proteomics and quantitative metabolomics) will be developed in conjunction with new computational modelling concepts to facilitate the understanding of biological complexity. The iterative process of simulations and model driven targeted experiments will generate ....To achieve major breakthroughs in the understanding of the regulation of gene transcription in bacteria at a global scale. High throughput technologies (living cell arrays, tiling DNA microarrays, multidimensional liquid chromatography proteomics and quantitative metabolomics) will be developed in conjunction with new computational modelling concepts to facilitate the understanding of biological complexity. The iterative process of simulations and model driven targeted experiments will generate novel hypotheses about the mechanistic nature of dynamic cellular responses, unravel emerging systems properties, and ultimately provide an efficient roadmap to tackle novel, pathogenic organisms.The role of my laboratory in this project is to perform subcellular localisation of transcription factors, establish standard operating procedures (with other groups) for growth, imaging and image analysis, precisely quantify 6 transcription factors under 3 standardised growth conditions for incorporation into metabolic models, and perform some analysis of transcription complexes.Read moreRead less
Self-perceived Oral Health Needs In Small Rural Communities In New South Wales
Funder
National Health and Medical Research Council
Funding Amount
$40,000.00
Summary
Residents of rural and remote NSW have more extractions, less focus on preventive oral heath care and lower dental satisfaction scores than metropolitan residents. There are fewer dentists in rural areas and waiting lists are lengthy. The profession must optimise the use of its limited resources in such areas to maximise the oral health care of residents. The opinions of rural and remote residents have not been considered previously. This project will determine individual and community perceptio ....Residents of rural and remote NSW have more extractions, less focus on preventive oral heath care and lower dental satisfaction scores than metropolitan residents. There are fewer dentists in rural areas and waiting lists are lengthy. The profession must optimise the use of its limited resources in such areas to maximise the oral health care of residents. The opinions of rural and remote residents have not been considered previously. This project will determine individual and community perceptions of oral health to inform the development of a community-centred oral health program.Read moreRead less
The Impact Of Declining Dental Needs Of Age Cohorts On The Cost-effectiveness Of Water Fluoridation & Supplementary Prev
Funder
National Health and Medical Research Council
Funding Amount
$85,600.00
Summary
This research will apply economic modelling, based on current trend-data by birth cohort on the effectiveness of water fluoridation to the evaluation of its continuing application to metropolitan water supplies. Wherever possible data from Victoria, and Australia as a whole, will be used in the modelling. It will explore the implications for policy-making in relation to maintenance of benefits gained and potential future application to non-fluoridated rural water supplies in Victoria. A key focu ....This research will apply economic modelling, based on current trend-data by birth cohort on the effectiveness of water fluoridation to the evaluation of its continuing application to metropolitan water supplies. Wherever possible data from Victoria, and Australia as a whole, will be used in the modelling. It will explore the implications for policy-making in relation to maintenance of benefits gained and potential future application to non-fluoridated rural water supplies in Victoria. A key focus is to identify and analyse data relating to the point at which there is a ‘plateauing-out’ of the benefits accruing from water fluoridation in middle and older age. The evaluation will also consider the policy implications of trends towards retention of more teeth into older age and the consequent increased exposure to both caries and periodontal disease.Read moreRead less
Dental Care And Oral Health For The Indigenous Communities Of South Australia's Mid-north
Funder
National Health and Medical Research Council
Funding Amount
$100,000.00
Summary
Improving access to dental services and oral health for Indigenous communities is a high priority. This project will initially involve the evaluation of oral health programs for Indigenous children in Port Augusta. This will guide the planning and implementation of programs for the other age groups and for the remote communities serviced by Pika Wiya Health Service. In addition, the project group will investigate the appropriateness of the developed strategies for implementation in other communi ....Improving access to dental services and oral health for Indigenous communities is a high priority. This project will initially involve the evaluation of oral health programs for Indigenous children in Port Augusta. This will guide the planning and implementation of programs for the other age groups and for the remote communities serviced by Pika Wiya Health Service. In addition, the project group will investigate the appropriateness of the developed strategies for implementation in other communities.Read moreRead less
Fluoridation Of Water Supplies In Remote Indigenous Communities In The NT: Requirements, Feasibility & Cost Effectivenes
Funder
National Health and Medical Research Council
Funding Amount
$72,559.00
Summary
The project has two major objectives: 1) to identify Indigenous communities that are likely to benefit most from fluoridation of the water supply, and 2) to examine the feasibility and impact of introducing a small scale fluoridation plant into at least one community. The first will be achieved through accurately mapping natural levels of fluoride in the water supply of Indigenous communities across the Northern Territory, and examining the oral health status of children in these communities. Th ....The project has two major objectives: 1) to identify Indigenous communities that are likely to benefit most from fluoridation of the water supply, and 2) to examine the feasibility and impact of introducing a small scale fluoridation plant into at least one community. The first will be achieved through accurately mapping natural levels of fluoride in the water supply of Indigenous communities across the Northern Territory, and examining the oral health status of children in these communities. The second will be achieved by installing a fluoridation plant in one or more communities that have been lobbying for fluoridation of their water supplies, and monitoring the maintenance requirements and costs of the plant, and the changes in dental health status in school children over a period of two to three years.Read moreRead less
A Best Practice Oral Health Model For Australian Residential Care
Funder
National Health and Medical Research Council
Funding Amount
$58,900.00
Summary
Carers are essential to the delivery of oral hygiene care and maintenance of residents’ oral health in residential care faclities. This research will investigate the role that carers can play to maintain adequate oral health for residents, and improving their timely referral and access to dental professionals. It will also assist with the development of appropriate policies and procedures for oral and dental care, in accordance with Commonwealth Residential Aged Care Standards
Effect Of A Personalised Oral Health Education Programme On Clinical And Molecular Risk Factors For At-risk Populations
Funder
National Health and Medical Research Council
Funding Amount
$149,900.00
Summary
Recently, a number of studies have shown that poor oral health may impact on general health. However, for many Australians on low incomes, the only dental care they receive is of an emergency nature due to the long waiting lists in the public sector. The current study proposes to look at whether an oral health education program delivered by allied oral health professionals will result in a significant improvement in oral health which in turn will lead to better oral and general health outcomes i ....Recently, a number of studies have shown that poor oral health may impact on general health. However, for many Australians on low incomes, the only dental care they receive is of an emergency nature due to the long waiting lists in the public sector. The current study proposes to look at whether an oral health education program delivered by allied oral health professionals will result in a significant improvement in oral health which in turn will lead to better oral and general health outcomes in a low socio-economic communityRead moreRead less
A Controlled Multi-faceted Community Intervention Trial To Improve The Oral Health Of Preschool Aged Child In Rural VIC
Funder
National Health and Medical Research Council
Funding Amount
$100,000.00
Summary
Pre-school aged children living in rural Victoria have worse dental health than that of their metropolitan counterparts. This is due in part to the lack of exposure to water fluoridation, difficulty accessing dental services and other sociodemographic issues. Whilst most pre-school aged children do not routinely get taken to a dentist, they do come into contact with local community nursing and medical staff. The aim of this project is to evaluate the feasibility and effectiveness of improving or ....Pre-school aged children living in rural Victoria have worse dental health than that of their metropolitan counterparts. This is due in part to the lack of exposure to water fluoridation, difficulty accessing dental services and other sociodemographic issues. Whilst most pre-school aged children do not routinely get taken to a dentist, they do come into contact with local community nursing and medical staff. The aim of this project is to evaluate the feasibility and effectiveness of improving oral health for these preschool aged children by developing oral health promotion skills in the existing local medical, nursing and dental practitioners, augmented by referral pathways that improve accessibility to dental services.Read moreRead less