Gammma Tocopherol Is An Important Dietary Antiinflammatory Agent.
Funder
National Health and Medical Research Council
Funding Amount
$281,636.00
Summary
Cardiovascular disease is the major source of death in developed countries. In Australia it accounts for more deaths than cancer and is associated with considerable economic cost. The use of antioxidant vitamin supplements for reduction of heart disease risk is now discouraged because several large studies with vitamin E (containing one form of vitamin E called alpha-tocopherol) have shown no benefit. However, there remains a major discrepancy between intervention studies using pure alpha-tocoph ....Cardiovascular disease is the major source of death in developed countries. In Australia it accounts for more deaths than cancer and is associated with considerable economic cost. The use of antioxidant vitamin supplements for reduction of heart disease risk is now discouraged because several large studies with vitamin E (containing one form of vitamin E called alpha-tocopherol) have shown no benefit. However, there remains a major discrepancy between intervention studies using pure alpha-tocopherol and population studies showing a benefit of diet derived antioxidants. We believe that this project will help clarify this discrepancy and provide data which may provide evidence for functional foods enriched with another form of vitamin E called gamma-tocopherol. Gamma-tocopherol is common in some foods and it may have different properties compared to alpha-tocopherol. We have already established that supplementation for six weeks with gamma-tocopherol leads to a marked increase in blood and tissue levels of gamma-tocopherol. Dietary gamma-tocopherol has potential antiinflammatory activity. This project will study how gamma-tocopherol may work as an antiinflammatory agent which could help to protect against heart disease. The project will clarify the potential role of dietary gamma-tocopherol in cardiovascular disease and strengthen the recommendation for mixed dietary 'antioxidants' in place of pure supplements such as alpha-tocopherol.Read moreRead less
Pharmacodynamics In Liver Disease And In Liver Surgery
Funder
National Health and Medical Research Council
Funding Amount
$899,646.00
Summary
The liver is the main organ in the body for drug metabolism and detoxification. This work seeks to address the poorly understood question: what is the in vivo disposition and response in liver of the drugs for treatment of liver diseases? The results of this work will help us better design new drugs and choose the most effective drugs for liver disease. The research may also help us find a better strategy for liver transplantation and thus improve success rates.
A Randomised Controlled Trial Of A Code Game Alarm Compared With A Standard Alarm For Treating Nocturnal Enuresis
Funder
National Health and Medical Research Council
Funding Amount
$349,740.00
Summary
Bedwetting affects 10% of school-aged children. It has psychosocial and cognitive effects on sufferers which is reversible with appropriate treatment. First line treatment for bedwetting is alarm therapy. 1-3 fail alarm treatment becaues of not waking to alarm noise. A novel alarm which enhances wakening has been developed and predicts to be 80-95% effective. This study compares the novel alarm to a standard alarm for treating bedwetting.This simple devise can be used in the home setting.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100099
Funder
Australian Research Council
Funding Amount
$154,000.00
Summary
Online dietary assessment for research: The Automated Self-Administered 24-Hour Dietary Recall System for Australia (ASA24-Aus). Online dietary assessment for research: the Automated Self-Administered 24-Hour Dietary Recall System for Australia: This project brings together key researchers nationally in the field of nutrition and dietetics to develop a standardised, high quality, online system to assess food intake among adults across a variety of research settings and study designs. The propose ....Online dietary assessment for research: The Automated Self-Administered 24-Hour Dietary Recall System for Australia (ASA24-Aus). Online dietary assessment for research: the Automated Self-Administered 24-Hour Dietary Recall System for Australia: This project brings together key researchers nationally in the field of nutrition and dietetics to develop a standardised, high quality, online system to assess food intake among adults across a variety of research settings and study designs. The proposed infrastructure is an Australian version of the Automated Self-Administered 24-Hour Dietary Recall (ASA24) in collaboration with the United States National Cancer Institute. The infrastructure is internationally renowned and will underpin research that builds the evidence-base for policies and programs in the field of nutrition and dietetics. Read moreRead less
Cash Transfers And Behaviour Change Communications To Reduce Child Undernutrition In Rural Bangladesh: A Cluster Randomized Controlled Trial To Determine The Most Effective Combination Of Interventions.
Funder
National Health and Medical Research Council
Funding Amount
$3,415,801.00
Summary
Under-nutrition of children remains a major global public health problem. Tackling this problem will require more evidence about what combination of nutrition-specific and nutrition sensitive interventions is most effective in reducing child undernutrition. We plan a large scale trial in rural Bangladesh to compare the effects of communications about nutrition with mobile phones and cash transfers in preventing child malnutrition.
Many dietary recommendations are inconsistent and based on inadequate research based on 1970s technologies. As a result, the current recommendations are almost impossible to meet from foods, without nutritional supplements. Using state-of-the-art technology, this research aims to redefine the nutritional requirements omega-3 long chain polyunsaturated fatty acids, iron and iodine, as well as the correct balance of energy producing macronutrients in the diet of mothers and their children.
Understanding meal patterns: developing the evidence-base for nutrition messages. Little is known about the format, structure or context of meal patterns despite their importance for health. This project will examine the predictors of meal patterns of Australians. This will provide new information which will facilitate the design of more effective ways to communicate with consumers about healthy eating.
Good nutrition is a vital element in a healthy start to life. Determining the correct foods to ensure that pregnant women meet both their needs as well as those of their new baby can be very confusing. Do I need to take iron supplements? How can I ensure I get enough iodine? This project will develop new methods for evaluating the effects of nutrients and to pass that information on to health practitioners so that Australian mothers will be in no doubt about the best diet for them and their chil ....Good nutrition is a vital element in a healthy start to life. Determining the correct foods to ensure that pregnant women meet both their needs as well as those of their new baby can be very confusing. Do I need to take iron supplements? How can I ensure I get enough iodine? This project will develop new methods for evaluating the effects of nutrients and to pass that information on to health practitioners so that Australian mothers will be in no doubt about the best diet for them and their children.Read moreRead less
SES And Injury In Children: A Cohort Study To Identify And Measure The Effects Of Preventable Mediating Factors
Funder
National Health and Medical Research Council
Funding Amount
$360,505.00
Summary
While changing an individual or group SES is at best a long term and challenging social objective, proximal risk factors for injury can be more readily modified. Once the proximal risk factor differential across SES groups has been adequately delineated, then the possibility arises for targeted public health intervention to redress the SES differential in the incidence of injury. The sophistication of the proposed modeling will result in a good assessment of the best point to target.