Quantification of the Remineralisation of Enamel. This project has three specific aims:
1. To quantify the ultrastructure and mechanisms of remineralisation of enamel using scanning and transmission electron microscopy.
2. To determine the mechanical properties of remineralised tissue and compare with those of sound enamel.
3. To develop an in-vivo optical fibre probe for monitoring and quantifying the changes of mineralised carious tissue during remineralisation.
This project will enable ....Quantification of the Remineralisation of Enamel. This project has three specific aims:
1. To quantify the ultrastructure and mechanisms of remineralisation of enamel using scanning and transmission electron microscopy.
2. To determine the mechanical properties of remineralised tissue and compare with those of sound enamel.
3. To develop an in-vivo optical fibre probe for monitoring and quantifying the changes of mineralised carious tissue during remineralisation.
This project will enable patients prone to orthodontic induced root resorption to be identified and also to assist with validating repair of enamel tooth structure in a non-surgical manner. It is anticipated to result in the development of a novel fibre optic instrument with applications beyond dentistry.
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Efficient and tailored supercontinuum generation using dispersion management. Imagine a laser beam, but not with just one colour, but containing all colours. The light beam thus looks white, somewhat like a search light, except that it is much brighter. We now know how to generate such bright white beams of light, but it is expensive, requiring a small specialized laboratory full of equipment. Through a better understanding, we will make it easier and cheaper to generate these light beams. All k ....Efficient and tailored supercontinuum generation using dispersion management. Imagine a laser beam, but not with just one colour, but containing all colours. The light beam thus looks white, somewhat like a search light, except that it is much brighter. We now know how to generate such bright white beams of light, but it is expensive, requiring a small specialized laboratory full of equipment. Through a better understanding, we will make it easier and cheaper to generate these light beams. All kinds of applications that have been known for years, such as medical imaging and chemical analysis, then suddenly become practical. We anticipate that in the future these bright white light beams will be used on a routine basis in Australian hospitals and industry. Read moreRead less
The photonic immunochip: retrieving individual Enzyme-linked Immuno Sorbent Assay (ELISA) array-units using optical waveguide multicolour fluorescence. Improving the sensitivity and availability of in-vitro immuno-diagnostic tests is a critical goal towards developing real time efficient tools for the detection of infectious diseases, cancers, allergies and auto-immune diseases. The goal is to increase the sensitivity of these tests by reducing background noise that has been a feature of the com ....The photonic immunochip: retrieving individual Enzyme-linked Immuno Sorbent Assay (ELISA) array-units using optical waveguide multicolour fluorescence. Improving the sensitivity and availability of in-vitro immuno-diagnostic tests is a critical goal towards developing real time efficient tools for the detection of infectious diseases, cancers, allergies and auto-immune diseases. The goal is to increase the sensitivity of these tests by reducing background noise that has been a feature of the commonly used ELISA technology. This will be achieved by developing a novel optical integrated waveguide array supporting a large range of distributed tests, including several based on a novel multi-colour detection scheme. This massively parallel approach will underpin a new generation of low-cost, efficient diagnostic tests.Read moreRead less
Modelling and Measurement of Flow-Structure Dynamics in the Human Upper Airway. Sleep disruption due to the common and disabling conditions of snoring and obstruction of the human upper airway can result in chronic fatigue, lost work and accidents caused by daytime drowsiness. To date the behaviour of the upper airway has not been adequately studied in terms able to reveal the mechanical causes of these conditions. This deficiency is addressed through the development and use of simulation tools ....Modelling and Measurement of Flow-Structure Dynamics in the Human Upper Airway. Sleep disruption due to the common and disabling conditions of snoring and obstruction of the human upper airway can result in chronic fatigue, lost work and accidents caused by daytime drowsiness. To date the behaviour of the upper airway has not been adequately studied in terms able to reveal the mechanical causes of these conditions. This deficiency is addressed through the development and use of simulation tools and measurement techniques that will elucidate the flow-structure dynamics leading to new diagnostic and improved treatment methods. Simulating the effect of treatment on any individual will permit it to be chosen to maximise its efficacy for a problem that costs the nation an estimated $2 Billion per year in lost productivity.Read moreRead less
Optical coherence elastography - High-resolution medical imaging of tissue mechanical properties. This project brings together an international, multi-disciplinary team to develop innovative, high-resolution techniques to identify diseased tissue. Success will result in a new medical imaging technique allowing clinicians to quantify the mechanical properties of tissue, effectively creating a high-resolution image of what the tissue 'feels' like. This may help them to more accurately identify can ....Optical coherence elastography - High-resolution medical imaging of tissue mechanical properties. This project brings together an international, multi-disciplinary team to develop innovative, high-resolution techniques to identify diseased tissue. Success will result in a new medical imaging technique allowing clinicians to quantify the mechanical properties of tissue, effectively creating a high-resolution image of what the tissue 'feels' like. This may help them to more accurately identify cancerous tissue during surgery and reduce rates of recurrence. It could aid in tissue engineering and regeneration and will provide a new database of tissue mechanical properties. The project will position Australia as a leader in this newly developing medical imaging technology, with significant potential for commercialisation.Read moreRead less
Biomedical Applications of Self-Mixing Sensors based on Vertical-Cavity Surface-Emitting Laser Arrays. The Vertical-Cavity Surface-Emitting Laser (VCSEL) is a new optical device of choice for high speed optical data networks. We propose that this communications technology can be used as a platform to develop a completely new family of sensors ideally suited to medical monitoring. Specifically, we will develop VCSEL based technology for measurement of heart activity and sensing of blood flow in ....Biomedical Applications of Self-Mixing Sensors based on Vertical-Cavity Surface-Emitting Laser Arrays. The Vertical-Cavity Surface-Emitting Laser (VCSEL) is a new optical device of choice for high speed optical data networks. We propose that this communications technology can be used as a platform to develop a completely new family of sensors ideally suited to medical monitoring. Specifically, we will develop VCSEL based technology for measurement of heart activity and sensing of blood flow in skin and tissues. This will provide novel sensors for heart monitoring and imaging, and management of skin disorders (burns and cancer).Read moreRead less
Thulium doped silica-based optical fibres - towards the realisation of an optical amplifier. In the last decade the data capacity of a single optical fibre has grown way beyond all expectations. However, our ability to utilise the available capacity continues to keep pace with any advance. This project has the potential to add substantially to the transmission capacity by developing an optical amplifier at wavelengths which, although available within the fibre, can not currently be utilised. The ....Thulium doped silica-based optical fibres - towards the realisation of an optical amplifier. In the last decade the data capacity of a single optical fibre has grown way beyond all expectations. However, our ability to utilise the available capacity continues to keep pace with any advance. This project has the potential to add substantially to the transmission capacity by developing an optical amplifier at wavelengths which, although available within the fibre, can not currently be utilised. The focus of the project is the study of thulium doped silica-based fibres for amplification in the 1460 to 1530 nm wavelength region. Read moreRead less
Photonic Crystals and Microstructured Optical Fibres for Device Applications. Photonic crystals and microstructured optical fibres, which are amongst the most exciting fields of modern optics and photonics, are set to underpin developments in the next generation of ultrahigh-bandwidth communications systems, the functionalities of which will be truly all-optical. This project will bring together of two leading research groups in these areas, enhancing their collaboration, complementing their ex ....Photonic Crystals and Microstructured Optical Fibres for Device Applications. Photonic crystals and microstructured optical fibres, which are amongst the most exciting fields of modern optics and photonics, are set to underpin developments in the next generation of ultrahigh-bandwidth communications systems, the functionalities of which will be truly all-optical. This project will bring together of two leading research groups in these areas, enhancing their collaboration, complementing their expertise, and enabling them to develop new theoretical and computational tools to facilitate device applications. The program will coordinate research over a broad front and bring real benefits to young researchers in both France and Australia.Read moreRead less
Multi-dimensional optical data storage based on nanophotonics - the third generation optical data storage technology. The key-sector in high tech markets has been the photonics industry over the last decade, and it will continue to revolutionise our ways of information storage, processing and transfer for the next 10 to 20 years. The current project of high-capacity Petabyte optical data storage, i.e the third generation optical data storage, will prove to be the key technological innovation in ....Multi-dimensional optical data storage based on nanophotonics - the third generation optical data storage technology. The key-sector in high tech markets has been the photonics industry over the last decade, and it will continue to revolutionise our ways of information storage, processing and transfer for the next 10 to 20 years. The current project of high-capacity Petabyte optical data storage, i.e the third generation optical data storage, will prove to be the key technological innovation in photonics (one of the National Research Priorities), which will not only meet the growing demands of the consumer market, but also continue to drive the industry and create new markets. This is in line with the Priority Goals set by the Minister for Education, Science and Training, as it will put Australia into the unique position in the information age. Read moreRead less
Nano-photonic fabrication and storage using near-field super-resolving probes. The aim of the project is to develop a novel near-field storage device and nano-fabrication instruments, which are based on the super-resolution technique. As a result, the new storage device has a density 100 times of the current DVD technology. The nano-fabrication techniques can be used for all optics devices of nanometer resolution for fast information transferring. This project extends the key developments in t ....Nano-photonic fabrication and storage using near-field super-resolving probes. The aim of the project is to develop a novel near-field storage device and nano-fabrication instruments, which are based on the super-resolution technique. As a result, the new storage device has a density 100 times of the current DVD technology. The nano-fabrication techniques can be used for all optics devices of nanometer resolution for fast information transferring. This project extends the key developments in the field of nano-photonics and will put Australia in a uniquely strong position in the internationally competitive information technology field.Read moreRead less