Nanoelectromechanical Mass Spectrometry with Molecular Imaging. This project aims to develop new technology to enable simultaneous measurement of the mass and conformation of single molecules. Mass spectrometry and high-resolution microscopy are independent analytical tools used widely to characterise the chemical and physical properties of molecules. This project aims to develop new technology based on advanced nanoelectromechanical systems that combines the capabilities of these complementary ....Nanoelectromechanical Mass Spectrometry with Molecular Imaging. This project aims to develop new technology to enable simultaneous measurement of the mass and conformation of single molecules. Mass spectrometry and high-resolution microscopy are independent analytical tools used widely to characterise the chemical and physical properties of molecules. This project aims to develop new technology based on advanced nanoelectromechanical systems that combines the capabilities of these complementary instruments. This would enable synchronous measurement of molecular mass and conformation with nanometre resolution. In contrast to current mass spectrometry, this technology could be operated in fluid and detect neutral species. This significant change in capability could be applied to advance biological and medical research.Read moreRead less
Meta-optics systems for driver-fatigue monitoring. The project aims to develop novel miniaturised optical systems for driver fatigue monitoring, which provide increased sensitivity, eliminate reflections from eyeglasses and enable accurate depth measurements of facial features. The unique performance of our optical systems is derived from the concept of optical nanostructured surfaces to allow for efficient control of light wavefront and polarisation. The project aims to apply this concept to de ....Meta-optics systems for driver-fatigue monitoring. The project aims to develop novel miniaturised optical systems for driver fatigue monitoring, which provide increased sensitivity, eliminate reflections from eyeglasses and enable accurate depth measurements of facial features. The unique performance of our optical systems is derived from the concept of optical nanostructured surfaces to allow for efficient control of light wavefront and polarisation. The project aims to apply this concept to develop six different optical elements with new functionalities and performance well beyond what is possible with conventional components. This development will enable the construction of high-performance driver monitoring systems, thus facilitating a safer driving experience for all.Read moreRead less
Integrated Nanoplatform for Multiomics Analysis of Cell-to-Cell Interaction. This project aims to develop an integrated nanoplatform for analysis of exosomes produced by host-pathogen interaction at the single cell level. This will be accomplished by engineering an innovative device involving plasmonic nanoparticles to probe exosomes molecular profiles over time. The intended outcome is a generic and robust platform for detailed molecular analysis of the consequences of cell-to-cell interactions ....Integrated Nanoplatform for Multiomics Analysis of Cell-to-Cell Interaction. This project aims to develop an integrated nanoplatform for analysis of exosomes produced by host-pathogen interaction at the single cell level. This will be accomplished by engineering an innovative device involving plasmonic nanoparticles to probe exosomes molecular profiles over time. The intended outcome is a generic and robust platform for detailed molecular analysis of the consequences of cell-to-cell interactions. Single cell scale will greatly improve detection accuracy for heterogeneous cell populations. Benefits will include new knowledge of cell-to-cell communication and intellectual property in manufacturing, which will foster collaborations across institutions and Australian industry by providing new technological solutions.Read moreRead less
Active Control of Light for Nonlinear Photonic Devices. In free space, light travels in a straight line, but since ancient times mankind has always sought to direct its propagation. Controlling light is an enduring problem in modern photonic technologies. The ultimate goal is to actively manipulate light propagation in space and time with a great accuracy. With this project we will investigate the fundamental science of active control of light in periodic structures and will provide a unique pla ....Active Control of Light for Nonlinear Photonic Devices. In free space, light travels in a straight line, but since ancient times mankind has always sought to direct its propagation. Controlling light is an enduring problem in modern photonic technologies. The ultimate goal is to actively manipulate light propagation in space and time with a great accuracy. With this project we will investigate the fundamental science of active control of light in periodic structures and will provide a unique platform for exploration of ground breaking optical physics, ensuring Australia remains a world leader in the field. Precision manipulation of light will form the basis of new techniques for all-optical signal processing and computing, with great impact on Australian photonic and defense industries.Read moreRead less
Nanoscale nonlinear optics. Advances in nanotechnology have led to the realisation of nanoscale photonic components that enable integration within electronic chips. Now the challenge is to make these components perform computing functions themselves, thus providing ultra-high operation speeds and reducing power consumption. This project will utilize the intensity dependent interaction of light with metal-dielectric nanostructures to establish new processing functions of the photonic components. ....Nanoscale nonlinear optics. Advances in nanotechnology have led to the realisation of nanoscale photonic components that enable integration within electronic chips. Now the challenge is to make these components perform computing functions themselves, thus providing ultra-high operation speeds and reducing power consumption. This project will utilize the intensity dependent interaction of light with metal-dielectric nanostructures to establish new processing functions of the photonic components. Our research underpins integration of photonics in future generations of computers and enables novel applications in subwavelength optical imaging and sensing. This project will therefore strongly enhance the standing of Australia in the field of nanotechnology.Read moreRead less
Gene Expression Profiling and de novo Transcriptome Sequencing using Geneballs. The purpose of the project is to demonstrate that bead-based technology can be used in applications that currently require DNA hybridisation in order to overcome existing deficiencies in microarray technology. By providing the capability to quickly and efficiently produce, screen and utilize biomolecule libraries of nearly unlimited size, this technology provides the key to unlock the power of genomics and proteomics ....Gene Expression Profiling and de novo Transcriptome Sequencing using Geneballs. The purpose of the project is to demonstrate that bead-based technology can be used in applications that currently require DNA hybridisation in order to overcome existing deficiencies in microarray technology. By providing the capability to quickly and efficiently produce, screen and utilize biomolecule libraries of nearly unlimited size, this technology provides the key to unlock the power of genomics and proteomics for use in real world applications. The project has two aspects. First, relatively small directed cDNA-bead libraries will be compared to known low-density cDNA microarrays to validate the technique for utility in gene expression profiling. Secondly, large libraries containing short oligonucleotide sequences will be used for de novo sequencing of a complete transcriptome. Proof-of-concept in either case will pave the way for many genomic applications and catapult the technology to 'blockbuster' status.Read moreRead less
Measurement and imaging of pathogenic and diagnostic iron oxide nanoparticles using proton magnetic resonance. This project is likely to result in new and improved technologies to aid in the management and diagnosis of a range of diseases including iron metabolism disorders such as thalassaemia and neurodegenerative diseases such as Alzheimer's disease. Other aspects of the research may lead to technologies for the early detection of some cancers. The technologies will enhance Australia's intern ....Measurement and imaging of pathogenic and diagnostic iron oxide nanoparticles using proton magnetic resonance. This project is likely to result in new and improved technologies to aid in the management and diagnosis of a range of diseases including iron metabolism disorders such as thalassaemia and neurodegenerative diseases such as Alzheimer's disease. Other aspects of the research may lead to technologies for the early detection of some cancers. The technologies will enhance Australia's international standing in the field of advanced medical imaging and have the potential to be commercialised within the Australian biotechnology sector. During the project, research students will receive high quality multidisciplinary training ensuring the supply of personnel with high-level technical expertise into the future.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989726
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
Nanophotonic and Microfluidic Integration Facility: a Platform for Optofluidics. Emerging 'lab on a chip' technology promises to provide low-cost, mass produced platforms for monitoring and processing of environmental and biological samples (eg. water quality and early cancer detection). These essentially fluidic platforms will require integrated photonic components to provide the vast array of optical interrogation options that are used in all modern laboratories. The proposed facility will e ....Nanophotonic and Microfluidic Integration Facility: a Platform for Optofluidics. Emerging 'lab on a chip' technology promises to provide low-cost, mass produced platforms for monitoring and processing of environmental and biological samples (eg. water quality and early cancer detection). These essentially fluidic platforms will require integrated photonic components to provide the vast array of optical interrogation options that are used in all modern laboratories. The proposed facility will enable Australian researchers to effectively integrate nano-photonic structures with engineered micro-fluidics into a single optofluidic chip. This will bring researchers in photonics and microfluidics together and will provide platforms supporting support biomedical and environmental and even fundamental physics projects.Read moreRead less