Gene Expression Profiling and de novo Transcriptome Sequencing using Geneballs. The purpose of the project is to demonstrate that bead-based technology can be used in applications that currently require DNA hybridisation in order to overcome existing deficiencies in microarray technology. By providing the capability to quickly and efficiently produce, screen and utilize biomolecule libraries of nearly unlimited size, this technology provides the key to unlock the power of genomics and proteomics ....Gene Expression Profiling and de novo Transcriptome Sequencing using Geneballs. The purpose of the project is to demonstrate that bead-based technology can be used in applications that currently require DNA hybridisation in order to overcome existing deficiencies in microarray technology. By providing the capability to quickly and efficiently produce, screen and utilize biomolecule libraries of nearly unlimited size, this technology provides the key to unlock the power of genomics and proteomics for use in real world applications. The project has two aspects. First, relatively small directed cDNA-bead libraries will be compared to known low-density cDNA microarrays to validate the technique for utility in gene expression profiling. Secondly, large libraries containing short oligonucleotide sequences will be used for de novo sequencing of a complete transcriptome. Proof-of-concept in either case will pave the way for many genomic applications and catapult the technology to 'blockbuster' status.Read moreRead less
ARC Centre of Excellence for Transformative Meta-Optical Systems. The ARC Centre of Excellence for Transformative Meta-Optical Systems will develop the next-generation of miniaturised optical systems with functionalities beyond what is conceivable today. By harnessing the disruptive concept of meta-optics, the Centre will overcome complex challenges in light generation, manipulation and detection at the nanoscale. The Centre brings together a trans-disciplinary team of world-leaders in science, ....ARC Centre of Excellence for Transformative Meta-Optical Systems. The ARC Centre of Excellence for Transformative Meta-Optical Systems will develop the next-generation of miniaturised optical systems with functionalities beyond what is conceivable today. By harnessing the disruptive concept of meta-optics, the Centre will overcome complex challenges in light generation, manipulation and detection at the nanoscale. The Centre brings together a trans-disciplinary team of world-leaders in science, technology and engineering to deliver scientific innovations in optical systems for the Fourth Industrial Revolution. The research outcomes will underpin future technologies, including real-time holographic displays, artificial vision for autonomous systems to see the invisible, and ultra-fast light-based WiFi.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100071
Funder
Australian Research Council
Funding Amount
$535,000.00
Summary
Photonic Chip Integration Facility. This project will create a Photonic Chip Integration Facility responding to newly emerging global trends towards low loss waveguides and wider coverage of the optical spectrum.
The tool will grow ultrahigh quality silicon nitride and oxide thin films in a manner that is compatible with electronics and other delicate materials, balancing flexibility for materials exploration with reliability and repeatability required for photonic chip systems research. The pr ....Photonic Chip Integration Facility. This project will create a Photonic Chip Integration Facility responding to newly emerging global trends towards low loss waveguides and wider coverage of the optical spectrum.
The tool will grow ultrahigh quality silicon nitride and oxide thin films in a manner that is compatible with electronics and other delicate materials, balancing flexibility for materials exploration with reliability and repeatability required for photonic chip systems research. The proposed facility will support Australian researchers from diverse disciplines spanning broadband networks, sensing, quantum technology, materials science, and beyond while providing a clear path for translating discoveries out of the lab towards scale up industrial manufacture
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Optically-driven micromachines and microtools. The use of optical forces to trap and manipulate microscopic particles has developed from a novelty into a widely used versatile research tool - optical tweezers. New advances, such as the application and optical measurement of optical torque, have been brought to the brink of practical application. We will apply these methods to the development and production of micromachines of unprecedently small size, and the development of new medical diagnosti ....Optically-driven micromachines and microtools. The use of optical forces to trap and manipulate microscopic particles has developed from a novelty into a widely used versatile research tool - optical tweezers. New advances, such as the application and optical measurement of optical torque, have been brought to the brink of practical application. We will apply these methods to the development and production of micromachines of unprecedently small size, and the development of new medical diagnostic techniques, and industrial and research tools.Read moreRead less
Multimodal biomedical imaging probes: development of advanced polymer nanocomposite devices for oncology. Despite significant research being directed toward cancer treatment, 7.6 million people died world wide in 2007. Early detection and treatment is widely recognised as being effective in significantly reducing mortality rates. Biomedical imaging techniques are routinely used for detection and staging of many cancers. However, greater sensitivity is required so that these techniques can be app ....Multimodal biomedical imaging probes: development of advanced polymer nanocomposite devices for oncology. Despite significant research being directed toward cancer treatment, 7.6 million people died world wide in 2007. Early detection and treatment is widely recognised as being effective in significantly reducing mortality rates. Biomedical imaging techniques are routinely used for detection and staging of many cancers. However, greater sensitivity is required so that these techniques can be applied to very early detection of tumours. To overcome this short-coming the next generation of imaging probes will be developed, which will require fundamental investigations in polymer and nanomaterials science to maximise imaging sensitivity and extend probe functionality. Successful outcomes will lead to significant benefits to healthcare in Australia.Read moreRead less
Structure of Epitaxial Semiconductor Quantum Dots. Epitaxially grown semiconductor quantum dots have received extensive attention in recent years due to their potential applications in electronic and optoelectronic devises. However, the quality of current grown quantum dots is still very far from that required for real device applications due to a lack of detailed knowledge of their nanostructures. This project aims to combine the strength of growing semiconductor quantum dots at Fudan Universit ....Structure of Epitaxial Semiconductor Quantum Dots. Epitaxially grown semiconductor quantum dots have received extensive attention in recent years due to their potential applications in electronic and optoelectronic devises. However, the quality of current grown quantum dots is still very far from that required for real device applications due to a lack of detailed knowledge of their nanostructures. This project aims to combine the strength of growing semiconductor quantum dots at Fudan University and the world-class characterisation facilities (advanced transmission electron microscopy) at the University of Queensland to actively explore optimum paths for epaxially growing device-quality semiconductor quantum dots.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453320
Funder
Australian Research Council
Funding Amount
$347,886.00
Summary
Advanced Spectroscopy for Nano-characterisation of Materials Chemistry and Properties. This application proposes to establish a cutting-edge spectroscopic facility which includes; electron energy-loss spectroscopy (EELS), energy-dispersive X-ray spectroscopy (EDS), cathodoluminescence (CL), photoluminescence (PL) and micro-Raman spectroscopy. Each of the spectrometers to be installed has significantly higher sensitivity and resolution than any other facility available in Australia and is capable ....Advanced Spectroscopy for Nano-characterisation of Materials Chemistry and Properties. This application proposes to establish a cutting-edge spectroscopic facility which includes; electron energy-loss spectroscopy (EELS), energy-dispersive X-ray spectroscopy (EDS), cathodoluminescence (CL), photoluminescence (PL) and micro-Raman spectroscopy. Each of the spectrometers to be installed has significantly higher sensitivity and resolution than any other facility available in Australia and is capable of full spectrum imaging. This new spectroscopic infrastructure will enable the knowledge-based development of new materials by allowing complete characterisation of structure-composition-property relationships at the nanometre level.Read moreRead less
A new nano-sensor technology for the detection and identification of residual vapours of explosives, drugs and chemicals in the air. Fighting terrorism and crime is one of the most important and difficult tasks that requires substantial human and technological resources. This project will help to address this enormous problem by developing a new optical sensor technology for the detection and identification of traces of chemicals, explosives, drugs and biological agents. It will develop a labora ....A new nano-sensor technology for the detection and identification of residual vapours of explosives, drugs and chemicals in the air. Fighting terrorism and crime is one of the most important and difficult tasks that requires substantial human and technological resources. This project will help to address this enormous problem by developing a new optical sensor technology for the detection and identification of traces of chemicals, explosives, drugs and biological agents. It will develop a laboratory prototype of this sensor that is expected to have superior sensitivity and operational capabilities. Thus it will noticeably contribute to practical law enforcement, air quality and environmental monitoring, counter-terrorism, air safety, border security and customs service. It will also lead to further development of nano-optics and nanotechnology in Australia. Read moreRead less
Beyond Microarrays: Nano-Scaled Devices for High Throughput Biomolecular Sensing. Current developments in Nanoscience and Nanotechnology hold many promises in terms of revolutionising our industrial base, transforming biology, medical science and practice. This project strives to achieve some of these aims by, for the first time, building and testing nano-scaled devices with the capability to 'read' massive amounts of biological information. With the recent completion of the Human Genome proje ....Beyond Microarrays: Nano-Scaled Devices for High Throughput Biomolecular Sensing. Current developments in Nanoscience and Nanotechnology hold many promises in terms of revolutionising our industrial base, transforming biology, medical science and practice. This project strives to achieve some of these aims by, for the first time, building and testing nano-scaled devices with the capability to 'read' massive amounts of biological information. With the recent completion of the Human Genome project, major opportunities exist to provide spectacular advances in human health care (eg, via personalised medicine) provided that appropriate high-throughput biological reading devices can be developed. In developing such devices, this project also aims to substantially catalyse the Australian Nanotechnology/Biotechnology industry.Read moreRead less