Ultrafast Photonic Electron Microscopy: Visualising dynamics at the nanoscale. The dynamics of molecular processes are too fast to observe with any microscope so science has instead relied on recording the static before and after states of these changes, inferring what happens in between. This project aims to combine the advantages of ultrafast photonic laser control and electron microscopy to allow the direct visualisation of dynamics at the nanoscale in physical and biological systems. By prov ....Ultrafast Photonic Electron Microscopy: Visualising dynamics at the nanoscale. The dynamics of molecular processes are too fast to observe with any microscope so science has instead relied on recording the static before and after states of these changes, inferring what happens in between. This project aims to combine the advantages of ultrafast photonic laser control and electron microscopy to allow the direct visualisation of dynamics at the nanoscale in physical and biological systems. By providing a view into how order emerges from the thermal chaos of molecular objects this project aims to help to reveal the physical basis for life.Read moreRead less
Imaging the invisible. This project aims to develop imaging technology to see and quantify objects normally invisible with X-rays. It will develop an X-ray imaging system that should provide orders of magnitude greater sensitivity to subtle changes in material composition than conventional radiography. It will devise quantitative image analysis tools for isolating specific materials of interest from complex multi-material samples, including low density components that often go undetected. Indust ....Imaging the invisible. This project aims to develop imaging technology to see and quantify objects normally invisible with X-rays. It will develop an X-ray imaging system that should provide orders of magnitude greater sensitivity to subtle changes in material composition than conventional radiography. It will devise quantitative image analysis tools for isolating specific materials of interest from complex multi-material samples, including low density components that often go undetected. Industries that could benefit significantly from this technology include airport security, the mining sector, agriculture, manufacturing quality control, and biomedical researchers studying anatomical form and function.Read moreRead less
Non-destructing X-ray testing. This project aims to improve imaging with X-rays, providing better image quality with higher throughput at a lower radiation dose. It will develop an X-ray imaging system that provides orders of magnitude greater sensitivity for detecting low-density objects that are often invisible with conventional X-ray scanners, and quantitative image analysis tools that can isolate materials from complex multi-material samples and detect individual chemical elements. Significa ....Non-destructing X-ray testing. This project aims to improve imaging with X-rays, providing better image quality with higher throughput at a lower radiation dose. It will develop an X-ray imaging system that provides orders of magnitude greater sensitivity for detecting low-density objects that are often invisible with conventional X-ray scanners, and quantitative image analysis tools that can isolate materials from complex multi-material samples and detect individual chemical elements. Significant benefits from these technologies are expected in industries including airport security, mining, agriculture, manufacturing quality control, and in research fields from medicine to geology.Read moreRead less
Dynamic multi-modal x-ray imaging. This project aims to create sensitive new methods of x-ray imaging that capture multiple image modalities with a single snapshot. Conventional x-ray imaging is widely used in a range of industries, but captures only a fraction of the rich information that is available in the x-ray wavefield. This project expects to extract additional image modalities to reveal x-ray-transparent features, and detect microscopic textures. By combining these capabilities with the ....Dynamic multi-modal x-ray imaging. This project aims to create sensitive new methods of x-ray imaging that capture multiple image modalities with a single snapshot. Conventional x-ray imaging is widely used in a range of industries, but captures only a fraction of the rich information that is available in the x-ray wavefield. This project expects to extract additional image modalities to reveal x-ray-transparent features, and detect microscopic textures. By combining these capabilities with the ability to capture images of a moving sample, this project will enable innovative biomedical and materials research studies, and develop new imaging technologies for use in security, hospitals and manufacturing. New methods of x-ray imaging will have wide-ranging benefits for society, the economy and healthcare.Read moreRead less
Single Shot X-ray Tomography For Real-Time Functional X-ray Imaging
Funder
National Health and Medical Research Council
Funding Amount
$322,641.00
Summary
Computed Tomography (CT) scanners produce three-dimensional images of vital organs that cannot be obtained by conventional two-dimensional (single projection) x-ray radiographs. However, the radiation exposure is hundreds of times higher than conventional radiography. We will develop the world’s first CT scanner that uses no more radiation than a single conventional x-ray image that will provide four-dimensional reconstructions of a patient’s moving internal organs.
Discovery Early Career Researcher Award - Grant ID: DE120101504
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Nano-resolution hard x-ray diffraction imaging with conventional laboratory sources. The project will combine advanced optics and algorithms for diffraction imaging to develop a desktop hard x-ray microscope. The system will display ultra-high resolution and will be highly complementary to electronic and optical microscopies for diverse applications in materials engineering, nanofluidics and cell biology.
Developing Interpretable Machine Learning Models For Clinical Imaging And Single-cell Genomics
Funder
National Health and Medical Research Council
Funding Amount
$1,312,250.00
Summary
Machine learning methods will be vital to make best use of the deluge of data generated by high-throughput technologies in biomedical science. To get the most out of these models, however, we need to be able to unpack the 'black box'. I will use curated clinical and public research data to benchmark and develop interpretable deep learning models and software tools. These models will be used for breast cancer screening programs and for analysis of complex, large-scale single-cell genomics data.
New quantitative methods in X-ray imaging using crystal optics. This project will enhance Australian science's international leadership in the area of x-ray imaging. This powerful type of X-ray imaging, which makes use of optical elements made of perfect crystals, is specially tailored to image samples which are invisible to conventional x-ray techniques. Such "extended x-ray vision" is extremely important for imaging in medicine, biology and materials science. Furthermore, we will train x-ray s ....New quantitative methods in X-ray imaging using crystal optics. This project will enhance Australian science's international leadership in the area of x-ray imaging. This powerful type of X-ray imaging, which makes use of optical elements made of perfect crystals, is specially tailored to image samples which are invisible to conventional x-ray techniques. Such "extended x-ray vision" is extremely important for imaging in medicine, biology and materials science. Furthermore, we will train x-ray scientists of tomorrow, whose expertise will allow Australia to capitalize on its investment in the Australian Synchrotron.Read moreRead less
Thulium doped silica-based optical fibres - towards the realisation of an optical amplifier. In the last decade the data capacity of a single optical fibre has grown way beyond all expectations. However, our ability to utilise the available capacity continues to keep pace with any advance. This project has the potential to add substantially to the transmission capacity by developing an optical amplifier at wavelengths which, although available within the fibre, can not currently be utilised. The ....Thulium doped silica-based optical fibres - towards the realisation of an optical amplifier. In the last decade the data capacity of a single optical fibre has grown way beyond all expectations. However, our ability to utilise the available capacity continues to keep pace with any advance. This project has the potential to add substantially to the transmission capacity by developing an optical amplifier at wavelengths which, although available within the fibre, can not currently be utilised. The focus of the project is the study of thulium doped silica-based fibres for amplification in the 1460 to 1530 nm wavelength region. Read moreRead less
High-performance smart solar powered on-chip capacitive energy storage. High performance and environmentally friendly on-chip power system is the key bottleneck issue limiting the further performance improvement and miniaturisation of ever-increasing portable optoelectronic devices. Building on previous work, including recent breakthroughs of on-chip photonic devices in patterned graphene oxide thin film and the record-breaking nanophotonics solar cells, the project aims to investigate a new con ....High-performance smart solar powered on-chip capacitive energy storage. High performance and environmentally friendly on-chip power system is the key bottleneck issue limiting the further performance improvement and miniaturisation of ever-increasing portable optoelectronic devices. Building on previous work, including recent breakthroughs of on-chip photonic devices in patterned graphene oxide thin film and the record-breaking nanophotonics solar cells, the project aims to investigate a new concept of super-resolution direct laser printing and simultaneous dopant activation of graphene oxide thin films. It is expected that the conceptually new development of the functional graphene oxide film patterning will allow for smart solar-powered on-chip power systems that outperform the state-of-the-art pollution generating batteries.Read moreRead less