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Developing Novel Neuroreceptor And Channel Therapies For Pain And Addiction
Funder
National Health and Medical Research Council
Funding Amount
$808,375.00
Summary
Chronic pain is a growing and poorly treated global health burden. There is a great need for novel pain therapeutics. We are discovering novel drug targets in pain pathways in the nervous system and new therapeutic molecules that selectively block information flow in pain nerves. Strong pain relieving drugs like morphine also lose their effectiveness after long periods of use. We are finding mechanisms responsible for this thereby providing a rational basis for development of better opioids and ....Chronic pain is a growing and poorly treated global health burden. There is a great need for novel pain therapeutics. We are discovering novel drug targets in pain pathways in the nervous system and new therapeutic molecules that selectively block information flow in pain nerves. Strong pain relieving drugs like morphine also lose their effectiveness after long periods of use. We are finding mechanisms responsible for this thereby providing a rational basis for development of better opioids and pain treatments.Read moreRead less
Reducing The Key Alcohol And Other Drug Related Harms In Australia
Funder
National Health and Medical Research Council
Funding Amount
$782,370.00
Summary
I am a leading alcohol and other drug researcher with an established national and international reputation for high quality research and translation. Over the next five years I will tackle the three key issues in the alcohol and other drug field: injecting drug use, methamphetamine use and harms and high risk drinking by young people, by developing, implementing and testing new interventions.
Inhibitory Neurotransmitter Receptors As Therapeutic Targets For Chronic Pain And Anxiety Disorders
Funder
National Health and Medical Research Council
Funding Amount
$763,409.00
Summary
There are currently few effective long-term treatments for chronic pain and anxiety disorders. Here we propose to develop innovative therapies for both of these debilitating neurological disorders. In addition, we plan to improve our current understanding of how these disorders occur in the first place. This may identify novel potential therapeutic strategies for treating pain, anxiety and a host of other neurological disorders.
Molecular Characterisation Of Steroid Hormone-dependent Diseases Of The Cardiovascular And Reproductive Systems
Funder
National Health and Medical Research Council
Funding Amount
$1,085,790.00
Summary
Peter Fuller is both a molecular and clinical endocrinologist. His research examines steroid hormones in cardiovascular disease and cancer. The hormone aldosterone controls blood pressure and has a significant role in cardiac failure. This work will enable the development of tissue-specific blockers of aldosterone for the treatment of cardiovascular disease. Steroid hormones also have a role in granulosa cell tumours of the ovary and breast cancer; new insights will lead to novel therapeutics.
Pattern Recognition Receptors In Inflammation And Infection
Funder
National Health and Medical Research Council
Funding Amount
$622,655.00
Summary
Innate immunity provides our first line of defence against infections, but pathogens can overcome this system. Understanding how microbes disable innate immunity can teach us how to prevent and/or treat infectious diseases. Innate immunity acts by initiating inflammation. Many important acute and chronic diseases develop when this process is dysregulated. Blocking innate immunity thus has potential to treat many diseases. This project aims to understand innate immunity in these contexts.
Understanding The Pathophysiology Of Schizophrenia, Major Depressive Disorder And Bipolar Disorder As A Basis For Improving Treatments
Funder
National Health and Medical Research Council
Funding Amount
$804,106.00
Summary
The Applicant seeks to understand the causes of the schizophrenia, bipolar disorder and major depressive disorder, which affect over 20% of the Australian population. This research is important as drug design, based on chemical remodelling, has not significantly advanced initial breakthroughs in treating psychiatric disorders and there is now a widespread belief that new drugs will only come from understand their causes.
Determining recurrence risk in breast cancer is crucial, as more than half of all recurrences occur after 5 years. However, optimal management of breast cancer is hampered by the challenges in finding rational preventative and predictive targets. Our vision is to find targets responsible for progenitor cell expansion, as candidates for prevention, and to find markers of relapse, to predict early versus late responders to therapy.
Hepatitis C virus (HCV) and Human immunodeficiency virus (HIV) infect 200 million and 50 million people world-wide, respectively, and there are no preventative vaccines. The work outlined in this fellowship seeks to understand the structure and function of the major surface proteins of these viruses, their ability to be recognised by the immune system and to develop a novel vaccine for the prevention of HCV.
Integrated Approaches To Targeting G Protein-coupled Receptors: Translational Studies Of Novel Drug-receptor Paradigms
Funder
National Health and Medical Research Council
Funding Amount
$851,980.00
Summary
This Fellowship focuses on one of the largest family of proteins found in the human body, the so-called ‘G protein-coupled receptors ‘ (GPCRs). GPCRs control how each of our cells communicates with one another, and have been implicated in virtually all diseases. This proposal will study new mechanisms of targeting drugs to GPCRs that can overcome current drug discovery bottlenecks and lead to new ways of treating neuropsychiatric, cardiovascular, inflammatory and metabolic diseases.
Research Fellowship: Understanding G Protein-coupled Receptors (GPCRs)
Funder
National Health and Medical Research Council
Funding Amount
$444,177.00
Summary
This project focuses on drug action at G protein-coupled receptors (GPCRs), the largest class of drug targets. It builds on key discoveries by the applicant that novel sites on GPCRs can be targeted by small molecules in a selective manner, thus minimizing side effects and maximizing therapeutic efficacy. Because this approach can work across most GPCR families, the relevance to the pharmaceutical industry and GPCR-related diseases, such as schizophrenia and diabetes, is very high.