Sleep Disordered Breathing In Pregnancy: Frequency And Impact.
Funder
National Health and Medical Research Council
Funding Amount
$607,034.00
Summary
Sleep disordered breathing (SDB)affects up to 15% of women during pregnancy. There is some evidence that it may have adverse effects on both mother and baby, particularly it may be associated with a 7-8 fold increase risk of developing hypertension during pregnancy. This study aims to measure breathing during sleep in pregnant women to determine its role in pregnancy-related hypertension and diabetes, then treat the SDB to assess its effect on maternal and foetal outcomes.
FUNCTIONAL IMAGING OF THE BRAINSTEM AND CORTICAL SITES OF BLOOD PRESSURE CONTROL IN HUMAN SUBJECTS IN HEALTH AND DISEASE
Funder
National Health and Medical Research Council
Funding Amount
$398,498.00
Summary
Disturbances in cardiovascular control underpin many diseases yet little is known about how the brain controls the heart and blood vessels. This project uses brain imaging (fMRI) and concurrent nerve recording in awake human subjects to increase our understanding of how normal blood pressure is maintained and how different disease states influence this control.
Revolution Of Sleep Diagnostics And Personalized Health Care Based On Digital Diagnostics And Therapeutics With Health Data Integration
Funder
National Health and Medical Research Council
Funding Amount
$500,000.00
Summary
Almost 1 billion people suffer from sleep apnoea. Unfortunately, the current diagnostic metric relates poorly to the symptoms and comorbidities of sleep apnoea merely measuring the frequency of breathing cessations. We aim to develop machine learning techniques to better estimate sleep apnoea severity. These techniques are implemented to high-end wearables developed in this project. Finally, we aim to design a digital diagnostic platform and create new standardised guidelines for sleep medicine.
Prediction Of Oral Appliance Treatment Outcome In Obstructive Sleep Apnoea
Funder
National Health and Medical Research Council
Funding Amount
$280,200.00
Summary
Obstructive sleep apnoea (OSA) is a very common disorder, affecting approximately 2% of women and 4% of men in the middle-aged workforce . It is characterised by repetitive, complete or partial closure of the throat passage during sleep, resulting in sleep disturbance and low oxygen levels. OSA is recognised as a serious public health problem. There is growing evidence supporting the use of oral appliances to treat OSA. It is thought that these work by enlarging the throat passage, but this rema ....Obstructive sleep apnoea (OSA) is a very common disorder, affecting approximately 2% of women and 4% of men in the middle-aged workforce . It is characterised by repetitive, complete or partial closure of the throat passage during sleep, resulting in sleep disturbance and low oxygen levels. OSA is recognised as a serious public health problem. There is growing evidence supporting the use of oral appliances to treat OSA. It is thought that these work by enlarging the throat passage, but this remains uncertain. The aim of this project is to gain a better understanding of how such appliances work, so as to be able to predict which patients will particularly benefit from this form of treatment.Read moreRead less
Biomechanical, Neural And Sensory Phenotyping Of The Upper Airway In Obstructive Sleep Apnoea
Funder
National Health and Medical Research Council
Funding Amount
$746,138.00
Summary
Obstructive sleep apnoea (OSA) is a common disorder where the upper airway closes repeatedly during sleep. It results in daytime sleepiness, increased risk of accidents and cardiovascular disease. But not all patients are the same, and individually tailored treatments are needed. This project will develop new ways to identify the causes of OSA in individual patients, using new MRI imaging methods, sensory testing, and measurements of the neural activity in the muscles that keep the airway open.
Surfactant Protein D As A Candidate Therapy In COPD
Funder
National Health and Medical Research Council
Funding Amount
$405,749.00
Summary
Smoking -related chronic bronchitis and emphysema, otherwise known COPD, costs the healthcare system over $800 million per year. People continue to suffer even after they have given up smoking, and the treatments available result in only modest improvements. COPD is associated with a a defect of the scavenging cells in the lung, which normally clear away dying cells, and some of the proteins ivolved in this process. We will investigate whether supplementing these proteins will help.
Obstructive Sleep Apnea And Androgen Dysregulation
Funder
National Health and Medical Research Council
Funding Amount
$537,041.00
Summary
Obstructive Sleep Apnea (OSA) is a serious public health problem associated with increased sleepiness, heart disease and metabolic dysfunction. Obesity and male gender are important predisposing factors for OSA. This study will determine if short-term testosterone therapy can help improve OSA in men who are also dieting and exercising. It will also determine the genetic mechanisms by which testosterone might influence breathing during sleep and obesity.