Protracted Bacterial Bronchitis(PBB) In Children - Natural History, Innate Immunity And Obstructive Sleep Disorders
Funder
National Health and Medical Research Council
Funding Amount
$97,438.00
Summary
Recurrent episodes of prolonged wet cough in children, termed Protracted Bacterial Bronchitis (PBB), may cause long term lung damage. I am a paediatric respiratory and sleep subspecialist in training. Through our research we will investigate for abnormalities in the immune system of children with recurring episodes of PBB and follow these children over a 2 year period to determine whether they go on to develop lung scarring. We will also be looking for a link between PBB and obstructive sleep pr ....Recurrent episodes of prolonged wet cough in children, termed Protracted Bacterial Bronchitis (PBB), may cause long term lung damage. I am a paediatric respiratory and sleep subspecialist in training. Through our research we will investigate for abnormalities in the immune system of children with recurring episodes of PBB and follow these children over a 2 year period to determine whether they go on to develop lung scarring. We will also be looking for a link between PBB and obstructive sleep problems in children.Read moreRead less
Studies On The Effects Of Endogenous And Exogenous Opioids In Modulating Exercise-induced Dyspnoea In People With Moderate / Severe Chronic Obstructive Pulmonary Disease (COPD). Two Double-blind Randomised, Placebo Controlled Trials.
Funder
National Health and Medical Research Council
Funding Amount
$197,086.00
Summary
There is evidence that morphine-like chemicals made by the body itself help reduce breathlessness. It is not clear whether this response is because of the effects of these morphine-like chemicals on the brain, in the lung or both. This study will help understand where these chemicals act to reduce breathlessness in people with emphysema during exercise. Subsequently, it will also help to understand whether small, regular doses of morphine safely further reduce breathlessness during exercise.
Obstructive Sleep Apnoea Phenotypes And Treatment In Quadriplegia
Funder
National Health and Medical Research Council
Funding Amount
$599,635.00
Summary
Losing function in your arms and legs after an injury (quadriplegia) is a catastrophic event. Quadriplegia also results in obstructive sleep apnoea; a condition where the throat closes repeatedly while asleep causing sleepiness, poor concentration and cardiovascular diseases like stroke. Despite most people with quadriplegia having this disease, the cause is unknown. This project will thoroughly investigate obstructive sleep apnoea causes in people with quadriplegia and test a possible treatment
An Interdisciplinary Model Of Care For Early Detection Of Lung Damage, Smoking Cessation Support, And A Home-based Exercise/self-management Program
Funder
National Health and Medical Research Council
Funding Amount
$448,381.00
Summary
An interdisciplinary model of care comprising screening of long-term smokers for early detection of lung damage, smoking cessation support, and a home-based exercise/self-management program will be implemented and evaluated. This model could potentially reduce the burden of smoking, improve lung health and maintain health-related quality of life.
My research focuses on allergies and chronic respiratory disease in children, teenagers and adults. My goal is to identify the factors, which cause these conditions and also the factors, which can stop these conditions from getting worse. I will work with health professionals and the community to make sure the results of my research are used by doctors to improve the care of people with allergies and chronic respiratory diseases.
Targeting Oxidant-dependent Pathways To Improve Stroke Outcomes In COPD
Funder
National Health and Medical Research Council
Funding Amount
$1,069,574.00
Summary
Chronic Obstructive Pulmonary Disease (COPD) is a major incurable global health burden and is the 4th largest cause of death worldwide. Patients with COPD are at increased risk for stroke and this is even higher in the weeks following a lung viral infection. The reason for this is unknown so the aim of this study is to determine why people with COPD are at increased risk for stroke and then develop novel treatments to prevent or reduce stroke in COPD patients.
Asthma is a National Health Priority in Australia. This project follows the major international study of asthma and allergic diseases in adults. We will re-examine people who have taken part in previous studies in Melbourne. The project also surveys people of the same age currently living in the same area. Participants complete a short postal questionnaire. In the follow-up group, responders complete a more extensive questionnaire and come to our laboratory for clinical assessments.
What Are The Lifetime Clinical Predictors And Risk Factors For Multiple Phenotypes Of Adult Asthma, COPD And Sleep Disordered Breathing? Following Up The TAHS Cohort From 1st To 6th Decade
Funder
National Health and Medical Research Council
Funding Amount
$1,950,689.00
Summary
Breathing gets impaired and impact on the productivity and quality of life when chronic respiratory diseases rise with ageing. Adult chronic respiratory diseases are major causes of illness and death but there are still many gaps in knowledge on how best to prevent and manage these diseases. The proposed program will provide evidence to guide health policy and clinical management of these diseases. These original findings will be of great importance both nationally and internationally.