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Targeting IL-33 In Chronic Obstructive Pulmonary Disease (COPD), Chronic Asthma And Idiopathic Pulmonary Fibrosis (IPF)
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Lung diseases (emphysema, severe asthma & pulmonary fibrosis) are major burdens on Australian community and economy. Airway wounding is a key feature of all these diseases. Patients experience severe breathlessness seriously impacting quality of life and frequently leading to death. We will assess the potential of a new target (IL-33), & therapy (anti-IL-33) in suppressing wounding in experimental models and human tissues. This may lead to a new treatment to reverse and/or prevent lung diseases.
Improving Outcomes In Obstructive Sleep Apnoea Through Individualised Treatment Of Physiological Abnormalities
Funder
National Health and Medical Research Council
Funding Amount
$340,891.00
Summary
The most common treatment for obstructive sleep apnoea, continuous positive airway pressure, is only accepted by ~50% of patients. Individualised treatment options are urgently needed. In order to predict who will benefit from the common alternative therapies, my research will show how, upper airway surgery improves obstructive sleep apnoea at an individual level and develop tools that will help clinicians select patients for these therapies.
While many cases of asthma are mild, severe cases require extensive health care resources and are virtually unresponsive to conventional treatment. This project will investigate whether specific compounds released from the airway are able to cause lung damage and airway abnormalities similar to that in severe asthma. We will investigate whether these changes are responsive to conventional therapy and investigate a potential treatment for regaining this responsiveness in severe asthma.
The Role Of Long Non-coding RNA In Regulating Lung Immunity And Inflammation
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Chronic inflammatory diseases of the lung, asthma and COPD, account for significant morbidity and poor quality of life in our community. Respiratory infection is one of the major causes of exacerbation and affects 50-80% of both asthma and COPD patients admitted to hospital. These groups of patients are steroid resistance and difficult to manage. Our aim is to identify novel molecules important in regulating inflammation and to target them therapeutically to treat these patients.
Rehabilitation Exercise At Home (REACH): Improving Equity Of Access And Patient Related Outcomes. A Trial Of Telerehabilitation In Chronic Obstructive Pulmonary Disease (COPD).
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Chronic obstructive pulmonary disease (COPD) is a chronic lung condition, characterised by breathlessness, and poor exercise tolerance and quality of life. Exercise training (Pulmonary Rehabilitation) improves these problems, however, it is often difficult for people to access these programs, particularly in rural areas, due to lack of availability and issues surrounding transport. These projects aim to determine the benefits and costs of pulmonary rehabilitation delivered via the internet.
An Integrated Approach To Improving Patient-centred Care In Chronic Obstructive Pulmonary Disease
Funder
National Health and Medical Research Council
Funding Amount
$438,768.00
Summary
My research project aims to improve patient-centred care in chronic obstructive pulmonary disease (COPD), also known as emphysema, by developing, testing and implementing a decision aid for shared decision making. The decision aid will be for use during the patient-health provider encounter and will facilitate tailoring of COPD treatment to patient-defined health priorities and needs, thus improving adherence and outcomes.