Phosphorylation Of Synaptic Vesicle Glycoprotein 2 (SV2) Regulates Endocytosis Of Synaptotagmin For Synaptic Transmission
Funder
National Health and Medical Research Council
Funding Amount
$613,311.00
Summary
Antiepileptic drugs typically target ion transporters or neurotransmitter receptors. Synaptic vesicle glycoprotein 2 (SV2) is a rare example of a synaptic vesicle recycling protein that is the target of an antiepileptic drug. It also binds botulinum and tetanus neurotoxins. We discovered SV2 contains activity-dependent signalling molecules. Charactersation of these molecules and will allow a deeper understanding of the molecular basis for its role in epilepsy and toxin action.
The Role Of Protein Glycosylation In The Malaria Parasite
Funder
National Health and Medical Research Council
Funding Amount
$644,428.00
Summary
The parasites that cause malaria have unique proteins on their surface that are essential for infection of humans. These proteins are useful for making vaccines to train our immune system to recognize and block infection by the malaria parasite. Our latest research has shown that these proteins are modified with sugars that enhance parasite virulence. We are studying these modifications more closely to facilitate the development of improved malaria vaccines.