How do nutrient-regulated changes in mitochondrial protein acetylation and sirtuin activity affect mitochondrial function and insulin action? Lysine acetylation affects the function of many proteins. This project will examine how excess nutrient availability and altered sirtuin activity affects the acetylation state and function of mitochondrial proteins. This information may identify therapeutic targets to treat diseases associated with mitochondrial dysfunction.
Improving quality of life in chronic aphasia: reducing depression and increasing social connection and life participation through community aphasia groups. Aphasia, a communication disability resulting from brain injury and experienced by over 80,000 Australians, impacts significantly on social connection, well being and mental health. This program of research defines excellent community aphasia groups, an important preventative health measure and investigates their impact for Australians with a ....Improving quality of life in chronic aphasia: reducing depression and increasing social connection and life participation through community aphasia groups. Aphasia, a communication disability resulting from brain injury and experienced by over 80,000 Australians, impacts significantly on social connection, well being and mental health. This program of research defines excellent community aphasia groups, an important preventative health measure and investigates their impact for Australians with aphasiaRead moreRead less
Harnessing non-invasive brain stimulation to improve language function in healthy and pathological ageing. This project will examine how the ability of the ageing brain to process language can be improved by non-invasive brain stimulation. The findings have the potential to reveal new ways to treat language impairments in ageing-associated brain injury and disease.
Speech production in language-impaired speakers: Informing theoretical models and clinical practice regarding grammatical processing. This research examines how language is stored and processed in our minds and the ways this can go wrong. By improving our theory of language processing, the research will result in improved diagnosis and treatment for the ten per cent of Australians who suffer from communication impairment.