Developmental programming of adult stress responses: early life nutrition permanently alters stress and immune function. Obese children are more likely to grow up to be obese adults than normal-weight children are. Their early life diet may be at least partly to blame. Early life nutrition can also compromise ability to respond to stress or inflammation. This project will investigate how this occurs and if these effects are specific to the developmental period.
How do nutrient-regulated changes in mitochondrial protein acetylation and sirtuin activity affect mitochondrial function and insulin action? Lysine acetylation affects the function of many proteins. This project will examine how excess nutrient availability and altered sirtuin activity affects the acetylation state and function of mitochondrial proteins. This information may identify therapeutic targets to treat diseases associated with mitochondrial dysfunction.
Room-temperature quantum microscopy for advanced nanoscale imaging. Original, inspired and most often cross-disciplinary efforts are the only way to solve some of nature's most obscure mysteries. Successful development of high-resolution quantum microscopy will lead to a range of benefits for the community and the nation; from graduate student training in cutting edge technology, building links between academic, industry and government groups to providing new insights and approaches into diseas ....Room-temperature quantum microscopy for advanced nanoscale imaging. Original, inspired and most often cross-disciplinary efforts are the only way to solve some of nature's most obscure mysteries. Successful development of high-resolution quantum microscopy will lead to a range of benefits for the community and the nation; from graduate student training in cutting edge technology, building links between academic, industry and government groups to providing new insights and approaches into disease identification and therapy. This project aims to demonstrate a world-first in imaging sensitivity, and success will directly enhance Australia's global reputation as a leader in innovation and collaboration. Read moreRead less
Advanced computer simulations of star cluster evolution. The topic of this fellowship is dynamical simulations of star clusters using high-end graphics cards originally developed for the computer gaming industry. The proposed fellowship will thereby enhance Australia's capacity in the exploitation of high-performance computing and will give it a strong position in the new field of graphics card based simulations. The computer cluster built during the fellowship will also be an outstanding enviro ....Advanced computer simulations of star cluster evolution. The topic of this fellowship is dynamical simulations of star clusters using high-end graphics cards originally developed for the computer gaming industry. The proposed fellowship will thereby enhance Australia's capacity in the exploitation of high-performance computing and will give it a strong position in the new field of graphics card based simulations. The computer cluster built during the fellowship will also be an outstanding environment for the training of students. In addition, while Australia has a strong tradition in star cluster astronomy, it has so far not captured a leadership role in the theoretical analysis. The four years of this fellowship will allow it to establish a world-leading position in star cluster simulations.Read moreRead less
Mechanisms of nucleation with special emphasis on gas hydrates. Successful recovery of natural gas from hydrate reservoirs, flow assurance in natural gas pipelines, prevention of undesirable dissociation of methane hydrates in deep ocean sediments, sequestration of carbon dioxide and high density gas storage, all depend on timely formation and dissociation of gas hydrates. Controlled extraction of methane hydrates from, and simultaneous sequestration of carbon dioxide to, deep ocean sediments ha ....Mechanisms of nucleation with special emphasis on gas hydrates. Successful recovery of natural gas from hydrate reservoirs, flow assurance in natural gas pipelines, prevention of undesirable dissociation of methane hydrates in deep ocean sediments, sequestration of carbon dioxide and high density gas storage, all depend on timely formation and dissociation of gas hydrates. Controlled extraction of methane hydrates from, and simultaneous sequestration of carbon dioxide to, deep ocean sediments have been considered to be the 'next big thing' in energy and environment sectors. Sequestration of carbon dioxide is necessary not only for reducing the greenhouse gases in the atmosphere but also to stabilise the sediments once methane is extracted.Read moreRead less
The Quest for Ultimate Measurement Precision. Precision measurement is the foundation upon which modern technological society is built. The highest quality measurement devices rely on stable clocks for their operation. The group's existing research has been aimed at developing some of the world's most precise measurement tools based on clocks and lasers. In parallel with this, other scientists have developed the means for exquisite control of light on the microscopic scale. By combining these tw ....The Quest for Ultimate Measurement Precision. Precision measurement is the foundation upon which modern technological society is built. The highest quality measurement devices rely on stable clocks for their operation. The group's existing research has been aimed at developing some of the world's most precise measurement tools based on clocks and lasers. In parallel with this, other scientists have developed the means for exquisite control of light on the microscopic scale. By combining these two technologies, both of which lie at the extreme limit of precision, the group will develop a new generation of technology for fundamental science objectives as well as for industrial needs.Read moreRead less
Ringed photonic crystal fibres for broadband nonlinear optics. The technology developed from this project will enable organic molecules to be detected, identified and quantified. Because the technology is compact, easily engineered and low cost, it will lead to a dramatically increased capability for infrared spectroscopic measurement throughout biology and medicine, with specific benefits in agriculture, the food industry and defence.
Building child health through maternal wellbeing. Chronic diseases partly originate in the health & social circumstances of previous generations, during pregnancy, and in conditions during infancy and childhood. This project will draw from three community studies the researcher established to investigate how aspects of women's health affect their children's health and identify new opportunities for disease prevention.
Developing serial crystallography for room temperature structure & dynamics. This project aims to uncover the molecular structural dynamics of a bacterial enzyme responsible for protein folding in bacteria. This project expects to generate new knowledge to guide the development of a new type of antibacterial to circumvent antibiotic resistance. Expected outcomes of this project include new experimental, computational and simulation tools for dynamic X-ray crystallography including new capabiliti ....Developing serial crystallography for room temperature structure & dynamics. This project aims to uncover the molecular structural dynamics of a bacterial enzyme responsible for protein folding in bacteria. This project expects to generate new knowledge to guide the development of a new type of antibacterial to circumvent antibiotic resistance. Expected outcomes of this project include new experimental, computational and simulation tools for dynamic X-ray crystallography including new capabilities at the Australian Synchrotron for very small microcrystals of any biomolecule. This would provide a powerful new tool for the Australian structural biology community that should accelerate fundamental discoveries, including facilitating high-resolution structure determination of membrane proteins and drug development.Read moreRead less
Probing the limits of Gravitational Force Sensing. This project will develop innovative laser measurement topologies for probing the limits of gravitational force sensing. Of particular interest is the detection of gravitational waves from astrophysical sources. Technology developed in this project will be able to see gravitational forces from slow moving mass at great distances away. Implementation of this technology will enhance the terrestrial gravitational wave detectors to observe at lower ....Probing the limits of Gravitational Force Sensing. This project will develop innovative laser measurement topologies for probing the limits of gravitational force sensing. Of particular interest is the detection of gravitational waves from astrophysical sources. Technology developed in this project will be able to see gravitational forces from slow moving mass at great distances away. Implementation of this technology will enhance the terrestrial gravitational wave detectors to observe at lower frequencies. This project will ensure Australia's continued involvement in the international Advanced LIGO (Laser Interferometer Gravitational Observatory) project and guarantee Australian participation in the first direct detection of gravitational waves.Read moreRead less