The Role Of MTOR In The Ageing Liver: Implications For Paracetamol Hepatotoxicity
Funder
National Health and Medical Research Council
Funding Amount
$92,495.00
Summary
Nutritional interventions and a drug that mimics them, Rapamycin, are the only methods that have been shown to delay ageing and age-related diseases. A key protein in the liver called mTOR is the most likely target for the beneficial effects of these interventions. This study aims to characterize the effects of nutritional interventions and rapamycin on mTOR and markers of ageing in the liver. It also examines the effects of these interventions on the risk and mechanisms of developing paracetamo ....Nutritional interventions and a drug that mimics them, Rapamycin, are the only methods that have been shown to delay ageing and age-related diseases. A key protein in the liver called mTOR is the most likely target for the beneficial effects of these interventions. This study aims to characterize the effects of nutritional interventions and rapamycin on mTOR and markers of ageing in the liver. It also examines the effects of these interventions on the risk and mechanisms of developing paracetamol toxicity.Read moreRead less
Determining The Affect And Cost Effectiveness Of Nutrition In Critically Ill Patients From Intensive Care Unit Admission To Hospital Discharge.
Funder
National Health and Medical Research Council
Funding Amount
$138,964.00
Summary
Nutrition when you are severely unwell is very important to support recovery. Research is required to determine exactly how much nutrition is needed in severely ill patients to ensure their best recovery. This project aims to determine what effect nutrition has on clinical and functional outcomes of patients who are severely ill during their whole hospital stay. It will also aim to determine the cost effectiveness of nutrition for these patients.
So Like Your Mum! Is The Health Of Mothers In Far North Queensland Reflected In The Nutrition And Growth Of Their Children In Early Life?
Funder
National Health and Medical Research Council
Funding Amount
$96,631.00
Summary
The health, nutrition and growth of a baby reflect the health and nutrition status of its mother. We will link routine health service information for Indigenous mothers with information on the growth, haemoglobin and health of their young children to identify key factors in a mother’s pregnancy and before, influencing the future health and development of their babies. This study will shape interventions to improve the health of mothers, and thus improve the health of their children through life.
Assessment Of Non-communicable Diseases And Associated Risks Among Indonesian Adolescents
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Adolescents experience a significant burden of disease from preventable non-communicable diseases (NCDs) and several risk factors for later development of NCDs are potentially modifiable during adolescence. In Indonesia, limited data measuring NCD risk factors, prevalence and outcomes in adolescents contributes to a policy and practice gap. This study aims to explore the burden of NCDs experienced by Indonesian adolescents and examine opportunities for health system change.
The Development, Implementation And Evaluation Of A Randomised Controlled Trial Of Dietary Improvement As A Treatment Strategy For Major Depression.
Funder
National Health and Medical Research Council
Funding Amount
$71,047.00
Summary
The SMILES trial: “Supporting the Modification of lifestyle In Lowered Emotional States" is a randomised controlled trial that aims to investigate the efficacy and cost-efficacy of dietary improvement in the treatment of Major Depressive Episodes (MDE). My PhD is embedded within this RCT. We hypothesise that a structured dietary intervention, focusing on dietary improvement (a Modified Mediterranean diet), will be superior to a control condition (social support) in the treatment of MDE.
A Study To Describe The Impact Of Improved Affordability On Food Choices Made By Indigenous Customers In Remote Community Stores In Australia.
Funder
National Health and Medical Research Council
Funding Amount
$129,245.00
Summary
Poor nutrition is a major contributor to the level of disease experienced by Indigenous Australians, particularly those living in remote communities where the cost of food is higher than elsewhere, and people generally have low incomes. The cost of food and income are considered key factors limiting dietary improvement. This study explores the impact affordability has on food choice in remote Indigenous communities.
A Dietary Intervention For Sarcopenia In Cirrhosis
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Patients with chronic liver failure, or cirrhosis, suffer many complications. Sarcopenia, the loss of muscle and muscle weakness, is one of these. It is associated with reduced survival. Patients with cirrhosis have low levels of branched chain amino acids (BCAAs) which are used as building blocks for protein and energy in muscle. We aim to explore how oral supplements of BCAAs might improve muscle in this population. If this improves muscle mass, we also expect it may improve other outcomes.
Developing A National Salt Reduction Program For India
Funder
National Health and Medical Research Council
Funding Amount
$93,626.00
Summary
While the scientific evidence base providing the rationale for salt reduction in controlling hypertension is very strong, the data required to translate those scientific insights into policy and reduced population salt intake are mostly absent. Few countries, India included, have the data required to develop, implement and evaluate salt reduction programs tailored to their national circumstances. The overall goal of this 3-year project is to develop the evidence base required to formulate a nati ....While the scientific evidence base providing the rationale for salt reduction in controlling hypertension is very strong, the data required to translate those scientific insights into policy and reduced population salt intake are mostly absent. Few countries, India included, have the data required to develop, implement and evaluate salt reduction programs tailored to their national circumstances. The overall goal of this 3-year project is to develop the evidence base required to formulate a national salt reduction program for India.Read moreRead less
The Potential Benefit Of Resistant Starch On Zinc Retention And Its Potential For Utilisation In Infants At Risk Of Zinc Deficiency.
Funder
National Health and Medical Research Council
Funding Amount
$101,991.00
Summary
Resistant starch (RS) can promote absorption of minerals such as calcium and magnesium from the large intestine. As zinc deficiency in children from the developing world remains a major public health issue, we will use a rodent model to determine if RS can improve zinc absorption in growing rats with preceeding zinc deficiency. In parallel we will also determine whether infants, who are most vulnerable to the effects of zinc deficiency, have the gut bacteria required to utilise the potential and ....Resistant starch (RS) can promote absorption of minerals such as calcium and magnesium from the large intestine. As zinc deficiency in children from the developing world remains a major public health issue, we will use a rodent model to determine if RS can improve zinc absorption in growing rats with preceeding zinc deficiency. In parallel we will also determine whether infants, who are most vulnerable to the effects of zinc deficiency, have the gut bacteria required to utilise the potential and known health benefits of RS.Read moreRead less
The Impact Of Using EHealth Interventions To Improve Health Behaviours Through Dietary And Lifestyle Management In Patients With Chronic Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$37,657.00
Summary
People with chronic kidney disease, particularly those on haemodialysis, have complex dietary needs. The renal diet is an important part of treatment however it is often poorly adhered to. New methods to enhance patient education and their ability to manage their diet is needed. This research will evaluate the use of technology-based strategies to enhance patient care, particularly regarding their diet and lifestyle, with findings informing future practices in this area.