Epigenetic Regulation By PKC-theta In Human Breast Cancer Stem Cells.
Funder
National Health and Medical Research Council
Funding Amount
$818,132.00
Summary
Treating women with advanced breast cancer is difficult, and new drugs are needed to kill the cancer stem cells that cause recurrence. We think that a newly discovered protein, PKC-?, plays an important role in recurring breast cancer and can be targeted using novel ‘epigenetic’ drugs. Here, we will use cutting-edge DNA techniques to learn how this protein controls how cancer cells grow and produce the necessary data to show that targeting this protein is likely to be effective in real patients.
Space development of the HDLT Australian Plasma Thruster. The collaboration between the ANU research group and ASTRIUM/EADS, the largest European aerospace company, is a unique opportunity for Australia to capitalize on the new discovery of the Helicon Double Layer Thruster made at the ANU. This will allow the Australian space community to stay abreast of international developments in space propulsion and to be with the for-runners of this new technology.
ANU will have direct access to ASTRIUM ....Space development of the HDLT Australian Plasma Thruster. The collaboration between the ANU research group and ASTRIUM/EADS, the largest European aerospace company, is a unique opportunity for Australia to capitalize on the new discovery of the Helicon Double Layer Thruster made at the ANU. This will allow the Australian space community to stay abreast of international developments in space propulsion and to be with the for-runners of this new technology.
ANU will have direct access to ASTRIUM/EADS via the relationships developed in this project putting Australia in the enviable position of being an insider in future space developments concerning plasma thrusters and space technology in general.Read moreRead less
Positron Nano-Dosimetry: Fundamental Measurements of Positron Interactions and their use in State-of-the-Art Modelling of Positron Transport. This proposal will provide unique experimental and theoretical information on how positrons, the electron antiparticles, interact with matter, in particular with biologically important molecules. This data will be used in a unique set of modelling approaches which will provide, for the first time, an insight into how positrons are transported through gases ....Positron Nano-Dosimetry: Fundamental Measurements of Positron Interactions and their use in State-of-the-Art Modelling of Positron Transport. This proposal will provide unique experimental and theoretical information on how positrons, the electron antiparticles, interact with matter, in particular with biologically important molecules. This data will be used in a unique set of modelling approaches which will provide, for the first time, an insight into how positrons are transported through gases, liquids and ultimately, soft matter. It will thus have important ramifications for diagnostic tools such as Positron Emission Tomography. The fundamental research will also shed light on one of the key 'mysteries' of life - why the biological building blocks of life possess a definite " handedness", or chirality.Read moreRead less
Promoting active travel and public transport for a post-pandemic world. In many major cities, COVID-19 stimulated the provision of open streets, pop up bike lanes and widened pedestrian access, prompting unprecedented increases cycling and walking. While this type of infrastructure has always been supported by urban planners and designers, the pandemic has served as a vital inflection point, enabling cities to pursue long-term sustainable transport initiatives, including investment in Active Tra ....Promoting active travel and public transport for a post-pandemic world. In many major cities, COVID-19 stimulated the provision of open streets, pop up bike lanes and widened pedestrian access, prompting unprecedented increases cycling and walking. While this type of infrastructure has always been supported by urban planners and designers, the pandemic has served as a vital inflection point, enabling cities to pursue long-term sustainable transport initiatives, including investment in Active Travel (AT). There is an opportunity to promote AT as part of an integrated transport strategy, and to develop tools for the robust evaluation of AT impacts to inform future investment strategies. This proposal will provide our partner organisation Transport for New South Wales (with the knowledge required to achieve this.
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Pure and applied nuclear structure research with radioactive ion beams at Californium Rare Ion Breeder Upgrade (CARIBU). The structure of exotic neutron-rich nuclei will be investigated at the Californium Rare Ion Breeder Upgrade (CARIBU) radioactive ion beam facility using new and novel detector systems. The results will enhance our fundamental understanding of the atomic nucleus and stellar nucleosynthesis as well as provide important data for the development of next generation nuclear reactor ....Pure and applied nuclear structure research with radioactive ion beams at Californium Rare Ion Breeder Upgrade (CARIBU). The structure of exotic neutron-rich nuclei will be investigated at the Californium Rare Ion Breeder Upgrade (CARIBU) radioactive ion beam facility using new and novel detector systems. The results will enhance our fundamental understanding of the atomic nucleus and stellar nucleosynthesis as well as provide important data for the development of next generation nuclear reactors.Read moreRead less
Superdeformed nuclei and their decay: challenging nuclear models and probing quantum tunnelling. Nuclear superdeformation, where the atomic nucleus adopts an elongated, ellipsoidal shape and can undergo rapid rotation, offers a fascinating opportunity to study quantum mechanical effects in a system where single-particle and collective regimes overlap. The superdeformed shape itself is a spectacular example of collective motion in a mesoscopic system, while the rapid change to a sperhical shape ....Superdeformed nuclei and their decay: challenging nuclear models and probing quantum tunnelling. Nuclear superdeformation, where the atomic nucleus adopts an elongated, ellipsoidal shape and can undergo rapid rotation, offers a fascinating opportunity to study quantum mechanical effects in a system where single-particle and collective regimes overlap. The superdeformed shape itself is a spectacular example of collective motion in a mesoscopic system, while the rapid change to a sperhical shape is an excellent example of quantum-assisted tunnelling. The results of this project will shed light on this important process and provide a stringent test of our understanding of the nucleus.Read moreRead less
Unravelling the neutron lifetime puzzle with lattice quantum chromodynamics. This project will perform supercomputer simulations to confront one of the outstanding puzzles of nuclear and particle physics, the neutron lifetime. New knowledge will be generated through the development of novel theoretical and numerical techniques to increase the precision of the leading theoretical inputs required to predict the neutron lifetime. The outcomes will provide crucial theoretical guidance into understan ....Unravelling the neutron lifetime puzzle with lattice quantum chromodynamics. This project will perform supercomputer simulations to confront one of the outstanding puzzles of nuclear and particle physics, the neutron lifetime. New knowledge will be generated through the development of novel theoretical and numerical techniques to increase the precision of the leading theoretical inputs required to predict the neutron lifetime. The outcomes will provide crucial theoretical guidance into understanding the neutron; helping to guide the next-generation neutron experiments, from particle physics to applications in advanced materials science. The results will have immediate benefit by resolving the neutron lifetime puzzle, while enabling Australian scientists to take a leadership role in this area of fundamental science.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100197
Funder
Australian Research Council
Funding Amount
$438,000.00
Summary
In one zeptosecond: quantifying energy dissipation in heavy element fusion. This project aims to understand the process of energy dissipation in superheavy element fusion reactions. Using state-of-the art facilities unique to Australia, the first detailed measurements of the crucial early stages of these reactions will be made. This is expected to generate significant fundamental knowledge on why some superheavy element fusion reactions succeed, and why others fail. The outcomes are expected to ....In one zeptosecond: quantifying energy dissipation in heavy element fusion. This project aims to understand the process of energy dissipation in superheavy element fusion reactions. Using state-of-the art facilities unique to Australia, the first detailed measurements of the crucial early stages of these reactions will be made. This is expected to generate significant fundamental knowledge on why some superheavy element fusion reactions succeed, and why others fail. The outcomes are expected to significantly advance the fundamental understanding of nuclear reactions, and provide key guidance to international opportunities to create new superheavy elements and isotopes. Expected benefits include improving cancer treatments, understanding element abundance in the universe and improved safety in nuclear technologies.Read moreRead less
Imaging the spatial distribution of forces that bind quarks to a proton. This project will perform supercomputer simulations to resolve the distribution of forces acting on quarks inside the proton. New knowledge will be generated in the area of fundamental strong-interaction physics by developing innovative approaches to image novel features that have not been possible in the past. The outcomes will therefore open new research possibilities by expanding the capacity of the international communi ....Imaging the spatial distribution of forces that bind quarks to a proton. This project will perform supercomputer simulations to resolve the distribution of forces acting on quarks inside the proton. New knowledge will be generated in the area of fundamental strong-interaction physics by developing innovative approaches to image novel features that have not been possible in the past. The outcomes will therefore open new research possibilities by expanding the capacity of the international community to study strong interaction physics—including direct relevance to experimental research at the recently-upgraded Jefferson Lab in the US. In analogy to Rutherford's atomic model, the results will have benefit to future generations of humanity with a deeper understanding of the structure of matter.Read moreRead less