Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
The origins of electroreception and nocturnality in the earliest known jawed vertebrates and their bearing on vertebrate diversification. This project aims to discover primary new data to pinpoint the timing, anatomical origins and phylogenetic significance when two key sensory systems first appeared in modern vertebrates: electroreception and specialised nocturnal vision. Such abilities today allow high diversity of vertebrates to co-exist within the same geographical range, for example on trop ....The origins of electroreception and nocturnality in the earliest known jawed vertebrates and their bearing on vertebrate diversification. This project aims to discover primary new data to pinpoint the timing, anatomical origins and phylogenetic significance when two key sensory systems first appeared in modern vertebrates: electroreception and specialised nocturnal vision. Such abilities today allow high diversity of vertebrates to co-exist within the same geographical range, for example on tropical reefs or rainforest communities, through careful temporal niche partitioning where reliance on other sensory systems takes over from vision and olfaction as the principal method of prey detection. This project aims to elucidate how the modern fish diversity was shaped by such significant early evolutionary events.Read moreRead less
Pure and applied nuclear structure research with radioactive ion beams at Californium Rare Ion Breeder Upgrade (CARIBU). The structure of exotic neutron-rich nuclei will be investigated at the Californium Rare Ion Breeder Upgrade (CARIBU) radioactive ion beam facility using new and novel detector systems. The results will enhance our fundamental understanding of the atomic nucleus and stellar nucleosynthesis as well as provide important data for the development of next generation nuclear reactor ....Pure and applied nuclear structure research with radioactive ion beams at Californium Rare Ion Breeder Upgrade (CARIBU). The structure of exotic neutron-rich nuclei will be investigated at the Californium Rare Ion Breeder Upgrade (CARIBU) radioactive ion beam facility using new and novel detector systems. The results will enhance our fundamental understanding of the atomic nucleus and stellar nucleosynthesis as well as provide important data for the development of next generation nuclear reactors.Read moreRead less
Superdeformed nuclei and their decay: challenging nuclear models and probing quantum tunnelling. Nuclear superdeformation, where the atomic nucleus adopts an elongated, ellipsoidal shape and can undergo rapid rotation, offers a fascinating opportunity to study quantum mechanical effects in a system where single-particle and collective regimes overlap. The superdeformed shape itself is a spectacular example of collective motion in a mesoscopic system, while the rapid change to a sperhical shape ....Superdeformed nuclei and their decay: challenging nuclear models and probing quantum tunnelling. Nuclear superdeformation, where the atomic nucleus adopts an elongated, ellipsoidal shape and can undergo rapid rotation, offers a fascinating opportunity to study quantum mechanical effects in a system where single-particle and collective regimes overlap. The superdeformed shape itself is a spectacular example of collective motion in a mesoscopic system, while the rapid change to a sperhical shape is an excellent example of quantum-assisted tunnelling. The results of this project will shed light on this important process and provide a stringent test of our understanding of the nucleus.Read moreRead less
Isomers as Probes of Nuclear Structure and Sources of Energetic Photons. The aim is to study exotic long-lived states in nuclei using accelerator facilities in Australia and overseas. This involves the development of sensitive instrumentation and will lead to a new understanding of how such states are formed, of how they may be used to identify the structure of exotic nuclei, and on the limits of stability of nuclei in general. Isomers represent a special form of nuclear matter and they play a r ....Isomers as Probes of Nuclear Structure and Sources of Energetic Photons. The aim is to study exotic long-lived states in nuclei using accelerator facilities in Australia and overseas. This involves the development of sensitive instrumentation and will lead to a new understanding of how such states are formed, of how they may be used to identify the structure of exotic nuclei, and on the limits of stability of nuclei in general. Isomers represent a special form of nuclear matter and they play a role in the formation of the elements in stellar nucleosynthesis. Stimulated isomer decay may ultimately lead to new forms of energy storage and gamma-ray lasers.Read moreRead less
Moments, monopoles and the emergence of nuclear collectivity. The project aims to elucidate the origin and nature of collective nuclear vibrations. Recent evidence that vibrational nuclei might not vibrate after all has shaken the foundations of nuclear theory. This project will measure electric monopole transitions and magnetic moments to help determine these nuclei’s true nature, and expose how their collectivity emerges from the complexity of the underlying single-particle motion. The expecte ....Moments, monopoles and the emergence of nuclear collectivity. The project aims to elucidate the origin and nature of collective nuclear vibrations. Recent evidence that vibrational nuclei might not vibrate after all has shaken the foundations of nuclear theory. This project will measure electric monopole transitions and magnetic moments to help determine these nuclei’s true nature, and expose how their collectivity emerges from the complexity of the underlying single-particle motion. The expected outcome is a deeper understanding of emergent phenomena in quantum many-body systems like the atomic nucleus.Read moreRead less
Quantum-number purity and limits to the formation of nuclear K-isomers. This internationally competitive research will result in new knowledge and the substantiation of Australian research in the nuclear structure area, as well as adding to our role in international scientific collaborations. The research is an important component of the local expertise in nuclear science established using Australian facilities which provide the major training ground for basic research, a variety of application ....Quantum-number purity and limits to the formation of nuclear K-isomers. This internationally competitive research will result in new knowledge and the substantiation of Australian research in the nuclear structure area, as well as adding to our role in international scientific collaborations. The research is an important component of the local expertise in nuclear science established using Australian facilities which provide the major training ground for basic research, a variety of applications and which also provide a source of strategically important expertise.
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Resolving evolutionary problems at the fish-tetrapod transition. The project aims to investigate very early Australian tetrapod trackways and conduct fieldwork to resolve the place of origin and timing of the evolution of the first tetrapods. The evolution of fishes to tetrapods was one of the key events in evolution. Studies on Northern Hemisphere fossils place an origin for the group around 380 million years ago. Australian fossils suggest a much older origin. New micro computed tomography dat ....Resolving evolutionary problems at the fish-tetrapod transition. The project aims to investigate very early Australian tetrapod trackways and conduct fieldwork to resolve the place of origin and timing of the evolution of the first tetrapods. The evolution of fishes to tetrapods was one of the key events in evolution. Studies on Northern Hemisphere fossils place an origin for the group around 380 million years ago. Australian fossils suggest a much older origin. New micro computed tomography data from Australian 3-D fossil fishes, combined with study of rare tetrapod gill arch bones, would enable us to determine the origins of tetrapod air-breathing and its ecological setting. The project may facilitate a rewriting of vertebrate evolution's most significant first step.Read moreRead less
Structure of Hadronic Excitations from Lattice Quantum Chromodynamics. Quantum chromodynamics describes the fundamental strong interactions between quarks and gluons as they compose hadrons such as the proton or neutron. Beyond these lowest-energy systems, the quantum mechanical excitation spectra display a rich and complex structure. Remarkably, little is known about the internal structure of these states. The central goal of this project is to unveil the nature of hadrons and their excited sta ....Structure of Hadronic Excitations from Lattice Quantum Chromodynamics. Quantum chromodynamics describes the fundamental strong interactions between quarks and gluons as they compose hadrons such as the proton or neutron. Beyond these lowest-energy systems, the quantum mechanical excitation spectra display a rich and complex structure. Remarkably, little is known about the internal structure of these states. The central goal of this project is to unveil the nature of hadrons and their excited states using the first principles approach of lattice gauge theory. By elucidating aspects of hadron structure in terms of the most fundamental non-perturbative quark and gluon fields, the project will create new knowledge impacting on renowned experimental programs at international facilities.Read moreRead less
Electromagnetic structure of hadronic excitations from lattice quantum chromodynamics. Just as quantum electrodynamics describes the quantum mechanical excitation spectra of atomic systems, quantum chromodynamics (QCD) describes the excitation spectra of quark and gluon systems, such as the proton. This project will resolve the internal structure of the low-lying excitations of QCD, as being investigated at international facilities.