Understanding Mitotic Telomere Deprotection. This project aims to study telomeres, the DNA and protein structures that protect chromosome ends. During cell division, cells under stress intentionally uncap their telomeres. This project expects to generate new knowledge that challenges the conventional notion of telomeres as static elements, showing instead that telomeres can be dynamic signalling hubs. Expected outcomes of this project include an understanding of the genetic, proteomic, and signa ....Understanding Mitotic Telomere Deprotection. This project aims to study telomeres, the DNA and protein structures that protect chromosome ends. During cell division, cells under stress intentionally uncap their telomeres. This project expects to generate new knowledge that challenges the conventional notion of telomeres as static elements, showing instead that telomeres can be dynamic signalling hubs. Expected outcomes of this project include an understanding of the genetic, proteomic, and signalling pathways involved in this novel phenomenon. This should provide significant benefits to our fundamental understanding of biological processes that protect human genomes and provide a valuable dataset for research on telomere biology, DNA repair, and genome stability.Read moreRead less
Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The pr ....Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The project will provide fundamental advances in our knowledge of the nutrient transport during pregnancy that is required to produce a healthy baby.Read moreRead less
Combining biomechanics and movement ecology of kangaroos and relatives. Kangaroos and their relatives are unique in their body form, hopping gait and by the fact that increased speed does not come at an increased energetic cost. This project aims to build 3D musculoskeletal models to understand how muscles and tendons interact, enabling greater distances to be travelled using less energy. Further, it will use animal tracking devices and machine-learning tools to quantify movements in the wild. T ....Combining biomechanics and movement ecology of kangaroos and relatives. Kangaroos and their relatives are unique in their body form, hopping gait and by the fact that increased speed does not come at an increased energetic cost. This project aims to build 3D musculoskeletal models to understand how muscles and tendons interact, enabling greater distances to be travelled using less energy. Further, it will use animal tracking devices and machine-learning tools to quantify movements in the wild. This framework will provide novel insights into how energetics, morphology, and habitat have shaped the evolution of this unique group. This may open doors to a range of future ecological, physiological, and conservation studies and provide biological inspiration for energetically efficient robotic and assistive devices.Read moreRead less
A Universal Power Law for Growth and Diversity of Dinosaur and Bird Beaks. Universal rules that govern how animals grow have tremendous power to explain the highly complex processes of growth and development. The project investigators have recently discovered a new rule of growth that controls how teeth, horns, claws and beaks are generated in animals. This project aims to use this new rule to examine the evolution and diversity of beaks in birds and dinosaurs. By combining 3D modelling, biomech ....A Universal Power Law for Growth and Diversity of Dinosaur and Bird Beaks. Universal rules that govern how animals grow have tremendous power to explain the highly complex processes of growth and development. The project investigators have recently discovered a new rule of growth that controls how teeth, horns, claws and beaks are generated in animals. This project aims to use this new rule to examine the evolution and diversity of beaks in birds and dinosaurs. By combining 3D modelling, biomechanics and genetic analysis of bird beak development with the study of dinosaur fossils, this project expects to reveal the underlying processes controlling the growth and evolution of beaks. The anticipated goal of this project is to show the power of new theoretical models to explain the diversity of life.Read moreRead less
A New Approach to the Structure of Atomic Nuclei. Starting at the quark level, we have derived a theory of nuclear structure, that in its initial application appears extremely successful. The aim of this project is to advance this revolutionary new approach to the theory of nuclear structure to the next level by exploring its predictions for a number of outstanding questions in modern nuclear physics. This includes the properties of superheavy nuclei, with atomic number beyond 100, including the ....A New Approach to the Structure of Atomic Nuclei. Starting at the quark level, we have derived a theory of nuclear structure, that in its initial application appears extremely successful. The aim of this project is to advance this revolutionary new approach to the theory of nuclear structure to the next level by exploring its predictions for a number of outstanding questions in modern nuclear physics. This includes the properties of superheavy nuclei, with atomic number beyond 100, including the potential existence of a new region of stability and complementing experimental searches underway internationally to discover the limits of stability with large neutron or proton excess, which is crucial to understanding the origin of the elements and may contribute new energy related technology.Read moreRead less
Skin in the game: biomimetics, fitness and the springtail cuticle. This project aims to examine the relationship between cuticle (skin) properties, water balance, and fitness in springtails, key players in soil systems. Springtail cuticles are diverse, responsive, and extremely resistant to wetting by water, alcohol and other substances. Their Australian diversity has not been well explored for biomimetic new materials. This project expects to explore options for new applications in materials sc ....Skin in the game: biomimetics, fitness and the springtail cuticle. This project aims to examine the relationship between cuticle (skin) properties, water balance, and fitness in springtails, key players in soil systems. Springtail cuticles are diverse, responsive, and extremely resistant to wetting by water, alcohol and other substances. Their Australian diversity has not been well explored for biomimetic new materials. This project expects to explore options for new applications in materials science and engineering by generalising the cuticle structure-function relationship. Expected outcomes are new information to harness for industry the diversity of nature’s self-cleaning, water repellent surfaces. Significant benefits lie in potential new biomimetic manufacturing options.Read moreRead less
Unravelling the neutron lifetime puzzle with lattice quantum chromodynamics. This project will perform supercomputer simulations to confront one of the outstanding puzzles of nuclear and particle physics, the neutron lifetime. New knowledge will be generated through the development of novel theoretical and numerical techniques to increase the precision of the leading theoretical inputs required to predict the neutron lifetime. The outcomes will provide crucial theoretical guidance into understan ....Unravelling the neutron lifetime puzzle with lattice quantum chromodynamics. This project will perform supercomputer simulations to confront one of the outstanding puzzles of nuclear and particle physics, the neutron lifetime. New knowledge will be generated through the development of novel theoretical and numerical techniques to increase the precision of the leading theoretical inputs required to predict the neutron lifetime. The outcomes will provide crucial theoretical guidance into understanding the neutron; helping to guide the next-generation neutron experiments, from particle physics to applications in advanced materials science. The results will have immediate benefit by resolving the neutron lifetime puzzle, while enabling Australian scientists to take a leadership role in this area of fundamental science.Read moreRead less
Imaging the spatial distribution of forces that bind quarks to a proton. This project will perform supercomputer simulations to resolve the distribution of forces acting on quarks inside the proton. New knowledge will be generated in the area of fundamental strong-interaction physics by developing innovative approaches to image novel features that have not been possible in the past. The outcomes will therefore open new research possibilities by expanding the capacity of the international communi ....Imaging the spatial distribution of forces that bind quarks to a proton. This project will perform supercomputer simulations to resolve the distribution of forces acting on quarks inside the proton. New knowledge will be generated in the area of fundamental strong-interaction physics by developing innovative approaches to image novel features that have not been possible in the past. The outcomes will therefore open new research possibilities by expanding the capacity of the international community to study strong interaction physics—including direct relevance to experimental research at the recently-upgraded Jefferson Lab in the US. In analogy to Rutherford's atomic model, the results will have benefit to future generations of humanity with a deeper understanding of the structure of matter.Read moreRead less
Nuclear vibrations under scrutiny in near-spherical and deformed nuclei. This Project aims to elucidate the nature of nuclear vibrations. Evidence is mounting that nuclear excitations long identified as vibrations cannot truly be so. This shakes the foundations of nuclear theory. Coulomb excitation and transfer reaction experiments are to be developed to probe the structure of these quantum states. Expected outcomes include clarification of their true nature and a deeper understanding of why nuc ....Nuclear vibrations under scrutiny in near-spherical and deformed nuclei. This Project aims to elucidate the nature of nuclear vibrations. Evidence is mounting that nuclear excitations long identified as vibrations cannot truly be so. This shakes the foundations of nuclear theory. Coulomb excitation and transfer reaction experiments are to be developed to probe the structure of these quantum states. Expected outcomes include clarification of their true nature and a deeper understanding of why nuclei differ from other many-body quantum systems that do vibrate. Anticipated benefits include enduring methodologies to facilitate international research engagement, and rigorous hands-on training in nuclear methods, to help meet Australia’s need for nuclear-qualified personnel in health, mining, industry and security.Read moreRead less
Supercomputing the tomography of the proton. This project aims to produce theoretical determinations of the quark and gluon distributions of the proton through advanced supercomputer simulations. The project will generate new knowledge in the area of fundamental strong-interaction physics by developing innovative approaches to image structures that have not been possible in the past. This project expects to expand the capacity of the international community to study strong interaction physics, i ....Supercomputing the tomography of the proton. This project aims to produce theoretical determinations of the quark and gluon distributions of the proton through advanced supercomputer simulations. The project will generate new knowledge in the area of fundamental strong-interaction physics by developing innovative approaches to image structures that have not been possible in the past. This project expects to expand the capacity of the international community to study strong interaction physics, including direct relevance to experimental research at the recently-upgraded Jefferson Lab in the US. In analogy to Rutherford's atomic model, the results will have benefit to future generations of humanity with a deeper understanding of the structure of matter.Read moreRead less