Understanding how cells compact and segregate DNA in vertebrates. How a cell compacts and divides its DNA is still a major unanswered question in biology. This project will determine the way in which a cell compacts its DNA nearly ten thousand fold to allow the faithful and accurate segregation to daughter nuclei.
Resolving And Targeting The Complex Molecular Mechanisms Underlying GPCR Signalling
Funder
National Health and Medical Research Council
Funding Amount
$1,071,370.00
Summary
Receptors are located on the surface of all human cells to allow our cells to respond to their environment. Over 30% of prescription drugs act through particular receptors called GPCRs, however effective drugs without side effects are difficult to develop because we do not have a deep understanding of how GPCRs transmit complex signals. In this proposal we seek to resolve the atomic-level details of GPCR signalling to assist in the development of better drugs for a diverse range of diseases.
The New Dimensions of the Quantum Universe. This Fellowship will help build and strengthen significant world-class research capacity at the frontier of fundamental science. More students will be motivated to pursue careers in science, increasing the number of talented, world-class science graduates in Australia. It will forge strong research links both locally and internationally so as to enhance existing networks and create new ones. It will greatly enhance Australia's standing in particle phys ....The New Dimensions of the Quantum Universe. This Fellowship will help build and strengthen significant world-class research capacity at the frontier of fundamental science. More students will be motivated to pursue careers in science, increasing the number of talented, world-class science graduates in Australia. It will forge strong research links both locally and internationally so as to enhance existing networks and create new ones. It will greatly enhance Australia's standing in particle physics, the epitome of Big Science, and garner new respect from one of the world's most influential scientific communities. Having this kind of world-class research in Australia, will also help foster public education and advance the public understanding of fundamental science.
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Branes and unification. This project will explore theories which hypothesis that our universe is a 3-dimensional mem-(brane) residing in higher dimensional space. We will construct completely realistic theories and find ways to test them experimentally. This project is at the forefront of international developments in our understanding of the universe - an area that has grown in importance following the construction of the Large Hadron Collider at the European Giant accelerator laboraroty. The p ....Branes and unification. This project will explore theories which hypothesis that our universe is a 3-dimensional mem-(brane) residing in higher dimensional space. We will construct completely realistic theories and find ways to test them experimentally. This project is at the forefront of international developments in our understanding of the universe - an area that has grown in importance following the construction of the Large Hadron Collider at the European Giant accelerator laboraroty. The project will expose postgraduate students to exciting developments in this fascinating field pf physics.Read moreRead less
Particle physics and cosmology of neutrinos. Neutrinos are a particularly interesting class of elementary particle. The Standard Model of particle physics sees neutrinos as having exactly zero mass. However, recent experimental data have all but demonstrated that massless neutrinos are inconsistent with observations. If neutrinos have mass, then quantum mechanics allows them to oscillate between the different neutrino types as they propagate through space. Nonzero neutrino masses and the associa ....Particle physics and cosmology of neutrinos. Neutrinos are a particularly interesting class of elementary particle. The Standard Model of particle physics sees neutrinos as having exactly zero mass. However, recent experimental data have all but demonstrated that massless neutrinos are inconsistent with observations. If neutrinos have mass, then quantum mechanics allows them to oscillate between the different neutrino types as they propagate through space. Nonzero neutrino masses and the associated oscillations lead to important new physics in the elementary particle domain and in cosmology. This project will explore the implications of neutrino oscillations in diverse areas in particle physics and cosmology.Read moreRead less
The Origin of Mass at the Large Hadron Collider. The Large Hadron Collider is an enormous worldwide effort to understand the building blocks of the Universe. This project will help strengthen world-class research capacity in one of the most exciting frontiers of basic research. It will excite more high-achieving students to pursue careers in science increasing the number of talented graduates in Australia. In addition the big fundamental questions addressed in this research are of great fascin ....The Origin of Mass at the Large Hadron Collider. The Large Hadron Collider is an enormous worldwide effort to understand the building blocks of the Universe. This project will help strengthen world-class research capacity in one of the most exciting frontiers of basic research. It will excite more high-achieving students to pursue careers in science increasing the number of talented graduates in Australia. In addition the big fundamental questions addressed in this research are of great fascination to the general public and will help to further advance the public education of science.Read moreRead less
Origin of the Mass. A hundred metres below ground, under the French-Swiss border, scientists are preparing to travel back in time to study matter as it was in the first fractions of a second after the beginning of the Universe. They are building the world's largest scientific instrument to help reveal how this primordial matter developed into the building blocks that form the great diversity of today. Australian physicists are preparing to extract the few fundamental particles that will explain ....Origin of the Mass. A hundred metres below ground, under the French-Swiss border, scientists are preparing to travel back in time to study matter as it was in the first fractions of a second after the beginning of the Universe. They are building the world's largest scientific instrument to help reveal how this primordial matter developed into the building blocks that form the great diversity of today. Australian physicists are preparing to extract the few fundamental particles that will explain the origin of the mass from the debris of billions of proton collisions. While solving the major issue confronting particle physics today, we will train students who will subsequently apply their skills in fields as diverse as science, medicine, industry and finance.Read moreRead less
Predictions of nucleon-nucleus cross sections for all energies to 300 MeV based upon microscopic theories of N-A scattering. Cross sections from nucleon-nucleus scattering and reactions are central quantities of import in diverse fields of study. They are most important in evaluations for nucleon radiation therapy, in material science for radiation safety as well as damage to electronics, with use of accelerator technology for waste management as well as possible power generation. They are im ....Predictions of nucleon-nucleus cross sections for all energies to 300 MeV based upon microscopic theories of N-A scattering. Cross sections from nucleon-nucleus scattering and reactions are central quantities of import in diverse fields of study. They are most important in evaluations for nucleon radiation therapy, in material science for radiation safety as well as damage to electronics, with use of accelerator technology for waste management as well as possible power generation. They are important in fundamental physics problems as in nuclear astrophysics and in studies of radioactive nuclear ions. A theoretical framework is required to make reliable predictions of nucleon-nucleus scattering. This project seeks to establish predictive methods of analysis for all nucleon energies to 300 MeV. Read moreRead less
Frontiers of Theoretical Particle Physics. This project will involve PhD and other students, who will work at the frontiers of theoretical particle physics, which provides excellent training in model building and problem solving. They will serve the nation as physicists, but also as teachers, in the finance industry, in the public service and in think tanks, as our former students have done. The quest to understand the ultimate structure of matter has been a part of western culture for the las ....Frontiers of Theoretical Particle Physics. This project will involve PhD and other students, who will work at the frontiers of theoretical particle physics, which provides excellent training in model building and problem solving. They will serve the nation as physicists, but also as teachers, in the finance industry, in the public service and in think tanks, as our former students have done. The quest to understand the ultimate structure of matter has been a part of western culture for the last 2000 years or more. Media stories on this subject are popular, and our work will enable authoritative public outreach as the subject develops, and we find that our present understanding is not the complete story.Read moreRead less
The standard model of particle physics and beyond in the era of the Large Hadron Collider. This project will enhance the nation's intellectual culture and international standing through the study of original ideas about the nature of our universe. The advent of the Large Hadron Collider era, courtesy of the giant European accelerator laboratory called CERN, will revolutionise particle physics in the next few years. High achieving students are very excited by the research questions addressed in t ....The standard model of particle physics and beyond in the era of the Large Hadron Collider. This project will enhance the nation's intellectual culture and international standing through the study of original ideas about the nature of our universe. The advent of the Large Hadron Collider era, courtesy of the giant European accelerator laboratory called CERN, will revolutionise particle physics in the next few years. High achieving students are very excited by the research questions addressed in this proposal, so it will add significantly to the pool of highly-trained young Australians. They emerge as general problem solvers and flexible thinkers of high calibre in addition to becoming experts in particular areas. The big fundamental questions to be considered are also of great fascination to the general public.Read moreRead less