New Copper and Rhenium Radiopharmaceuticals. The aims of this project are to provide new metal-based radiopharmaceuticals for the treatment of cancer, and the imaging of cancer and other conditions through the design and engineering of new coordination complexes of rhenium and copper. Various strategies will be used to selectively and specifically target these metal complexes to the desired areas in vivo for non-invasive imaging and therapeutic applications. The most promising candidates will be ....New Copper and Rhenium Radiopharmaceuticals. The aims of this project are to provide new metal-based radiopharmaceuticals for the treatment of cancer, and the imaging of cancer and other conditions through the design and engineering of new coordination complexes of rhenium and copper. Various strategies will be used to selectively and specifically target these metal complexes to the desired areas in vivo for non-invasive imaging and therapeutic applications. The most promising candidates will be tested in the appropriate cells.Read moreRead less
Studying Molecular Dynamics with Electron and Laser Interactions. We plan to use state-of-the-art experimental techniques and methodologies to probe the dynamics of molecular processes stimulated by either laser or electron interactions. These processes are fundamental to our understanding of both natural phenomena and many devices used in the technology of today and of the future. As a result of this study our insight into the mechanisms underpining these phenomena and devices will be enhanced.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0219618
Funder
Australian Research Council
Funding Amount
$215,000.00
Summary
National Facility for Advanced Molecular Orbital Imaging. We will develop a new two-dimensional multiparameter high-resolution electron momentum spectroscopy (EMS) spectrometer that incorporates multiparameter data acquisition and reduction techniques and combine it with a new time of flight (TOF) ion-analyser in order to perform the first high-resolution EMS with oriented target experiments.
In conjunction with theoretical calculations, the results from these experiments will provide the most ....National Facility for Advanced Molecular Orbital Imaging. We will develop a new two-dimensional multiparameter high-resolution electron momentum spectroscopy (EMS) spectrometer that incorporates multiparameter data acquisition and reduction techniques and combine it with a new time of flight (TOF) ion-analyser in order to perform the first high-resolution EMS with oriented target experiments.
In conjunction with theoretical calculations, the results from these experiments will provide the most advanced evaluation for molecular orbital imaging quality for the chemically significant targets we wish to study. This in turn will lead to the determination of more accurate physico-chemical information, including structure and bonding information, for these targets.Read moreRead less
Cross sections for electron scattering from molecules and radicals of technological and environmental relevance. We will use two state of the art crossed beam spectrometers to measure absolute differential and integral cross sections for low energy electron scattering from molecules and their molecular fragments (radicals). The species to be considered are those of significant industrial (e.g. C2F4, C4F8 and CF2) and environmental (e.g. CO2 and H2O) interest, with the cross sections we will mea ....Cross sections for electron scattering from molecules and radicals of technological and environmental relevance. We will use two state of the art crossed beam spectrometers to measure absolute differential and integral cross sections for low energy electron scattering from molecules and their molecular fragments (radicals). The species to be considered are those of significant industrial (e.g. C2F4, C4F8 and CF2) and environmental (e.g. CO2 and H2O) interest, with the cross sections we will measure being crucial to our modelling both the processes involved in plasma enhanced chemical vapour desposition of semiconductor devices and the spectral emission characteristics of planetary atmospheres. The modelling will be conducted self-consistently with our enhanced statistical equilibrium simulation code, which is unique to Australia.Read moreRead less
Long range interactions of atoms. Atomic physics is often described as both a basic and enabling discipline and the present project on long range atomic interactions fits within both of those categories. The results of the project will lead to a more thorough understanding of the details of long range atom-atom interactions. This will lead to Australian expertise making a significant contribution in a number of cutting edge areas in atomic and molecular physics.
Application of variational methods in atomic and molecular physics. Atmoic physics is both a basic an enabling science and this project will improve fundamental knowledge about the interactions of electrons and positrons with atoms and molecules. Research will be directly relevant to the activities of the National Positron Beam-Line (located at the Australian National University) which is directed to break-through research in matter-antimatter interactions and materials characterisation.
....Application of variational methods in atomic and molecular physics. Atmoic physics is both a basic an enabling science and this project will improve fundamental knowledge about the interactions of electrons and positrons with atoms and molecules. Research will be directly relevant to the activities of the National Positron Beam-Line (located at the Australian National University) which is directed to break-through research in matter-antimatter interactions and materials characterisation.
Read moreRead less
Novel target of amiloride analogues - picornaviral RNA polymerase. Picornaviruses cause a range of diseases such as poliomyelitis, meningitis, myocarditis, hepatitis A, neonatal sepsis and common cold. No antiviral treatment is available for these infections. Nearly 50% of antiviral drugs used in medicine are viral polymerase inhibitors; however picornaviral RNA polymerase has been largely overlooked as a drug target. We have discovered a group of compounds that inhibit picornaviral RNA polymera ....Novel target of amiloride analogues - picornaviral RNA polymerase. Picornaviruses cause a range of diseases such as poliomyelitis, meningitis, myocarditis, hepatitis A, neonatal sepsis and common cold. No antiviral treatment is available for these infections. Nearly 50% of antiviral drugs used in medicine are viral polymerase inhibitors; however picornaviral RNA polymerase has been largely overlooked as a drug target. We have discovered a group of compounds that inhibit picornaviral RNA polymerase. This project aims to define the inhibition mechanism and to evaluate a potential use of these compounds for antiviral drug development.Read moreRead less
Functionalised MMP Inhibitors as Radiodiagnostic, Radiotherapeutic, and Radiation-Sensitising Agents for Metastatic Cancer. Identifying and treating malignant cancers is one of the major challenges facing the scientific and medical communities. In order to minimise side effects that accompany most treatments of cancer it is necessary to find ways of targeting the therapy to tumours and away from healthy organs. A difference between tumours and healthy tissues is the amount of the proteins (calle ....Functionalised MMP Inhibitors as Radiodiagnostic, Radiotherapeutic, and Radiation-Sensitising Agents for Metastatic Cancer. Identifying and treating malignant cancers is one of the major challenges facing the scientific and medical communities. In order to minimise side effects that accompany most treatments of cancer it is necessary to find ways of targeting the therapy to tumours and away from healthy organs. A difference between tumours and healthy tissues is the amount of the proteins (called MMPs) that tumours use to break out of their surroundings, to break into and out of the blood system, and to establish new colonies of cancer cells or metastases. This difference also distinguishes the most aggressive cancers. The purpose of this project is to develop means of identifying and targeting cancers using molecules that bind to these MMP proteins.Read moreRead less
Understanding Collisions of Cold Polar Molecules. This project is in a high impact research field and therefore has several immediate and substantial national benefits. First, this project will directly raise the quality of Australian science in ultracold atomic physics, cold polar molecules physics, and quantum chemistry. Second, it will constitute high impact research from an Australian institute which will raise the recognition of the high quality Australian science. Third, it will further ....Understanding Collisions of Cold Polar Molecules. This project is in a high impact research field and therefore has several immediate and substantial national benefits. First, this project will directly raise the quality of Australian science in ultracold atomic physics, cold polar molecules physics, and quantum chemistry. Second, it will constitute high impact research from an Australian institute which will raise the recognition of the high quality Australian science. Third, it will further develop capabilities of the ARC Centre of Excellence for Quantum-Atom Optics (ACQAO). Fourth, this work will start high calibre international collaborations, most notably with a world renowned experimental group at Yale University among others.Read moreRead less
Electron and Positron Interactions with Bio-Molecules. This program of research will quantify reaction rates and elucidate reaction pathways for a range of important processes in our bodies involving ionising radiation. It will lead to a greatly improved understanding of positron and electron interactions with biological systems, including DNA and its constituent molecules and, through a better understanding of the underlying fundamental interactions, will lay foundations for improvements in te ....Electron and Positron Interactions with Bio-Molecules. This program of research will quantify reaction rates and elucidate reaction pathways for a range of important processes in our bodies involving ionising radiation. It will lead to a greatly improved understanding of positron and electron interactions with biological systems, including DNA and its constituent molecules and, through a better understanding of the underlying fundamental interactions, will lay foundations for improvements in technologies such as PET imaging. Read moreRead less