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EFR3: Novel gatekeeper of cell proliferation. This interdisciplinary, cross-institutional project uses leading-edge mass spectrometry and the yeast genetic model to enhance knowledge of fundamental signalling mechanisms common to cell proliferation of eukaryotic cells. Building on extensive preliminary data that identifies novel energy-stress control points, this research will generate insights into critical and conserved features of nutrient stress control of cell proliferation that ensures cel ....EFR3: Novel gatekeeper of cell proliferation. This interdisciplinary, cross-institutional project uses leading-edge mass spectrometry and the yeast genetic model to enhance knowledge of fundamental signalling mechanisms common to cell proliferation of eukaryotic cells. Building on extensive preliminary data that identifies novel energy-stress control points, this research will generate insights into critical and conserved features of nutrient stress control of cell proliferation that ensures cell survival. This project advances basic and applied biology. Its outcomes will be relevant to several research areas and industries, specifically to the propagation of cell cultures that nowadays contributes to the production of a myriad of biotechnical and pharmaceutical commodities.
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Target Of Rapamycin control of nutrient uptake. This project aims to study nutrient uptake in eukaryotes. It is expected to generate new knowledge of critical and conserved features of environmental and Target Of Rapamycin (TOR)-mediated control of nutrient uptake, specifically endocytosis, building on novel preliminary data that identifies novel TOR control points. The expected outcomes include new insights into mechanisms controlling nutrient uptake and fostering institutional collaboration. T ....Target Of Rapamycin control of nutrient uptake. This project aims to study nutrient uptake in eukaryotes. It is expected to generate new knowledge of critical and conserved features of environmental and Target Of Rapamycin (TOR)-mediated control of nutrient uptake, specifically endocytosis, building on novel preliminary data that identifies novel TOR control points. The expected outcomes include new insights into mechanisms controlling nutrient uptake and fostering institutional collaboration. This knowledge is highly relevant to any industry or research project utilising living organisms, as nutrient availability supports survival, cell growth and proliferation.Read moreRead less
How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent si ....How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent signaling. Expected outcomes include novel insights into environmental control of cell proliferation and forging cross institutional collaborations. This knowledge benefits basic and applied biology and is relevant to industries/projects utilizing living cells as nutrient supports cell survival and proliferation.Read moreRead less
A New Approach to the Structure of Atomic Nuclei. Starting at the quark level, we have derived a theory of nuclear structure, that in its initial application appears extremely successful. The aim of this project is to advance this revolutionary new approach to the theory of nuclear structure to the next level by exploring its predictions for a number of outstanding questions in modern nuclear physics. This includes the properties of superheavy nuclei, with atomic number beyond 100, including the ....A New Approach to the Structure of Atomic Nuclei. Starting at the quark level, we have derived a theory of nuclear structure, that in its initial application appears extremely successful. The aim of this project is to advance this revolutionary new approach to the theory of nuclear structure to the next level by exploring its predictions for a number of outstanding questions in modern nuclear physics. This includes the properties of superheavy nuclei, with atomic number beyond 100, including the potential existence of a new region of stability and complementing experimental searches underway internationally to discover the limits of stability with large neutron or proton excess, which is crucial to understanding the origin of the elements and may contribute new energy related technology.Read moreRead less
Pure and applied nuclear structure research with radioactive ion beams at Californium Rare Ion Breeder Upgrade (CARIBU). The structure of exotic neutron-rich nuclei will be investigated at the Californium Rare Ion Breeder Upgrade (CARIBU) radioactive ion beam facility using new and novel detector systems. The results will enhance our fundamental understanding of the atomic nucleus and stellar nucleosynthesis as well as provide important data for the development of next generation nuclear reactor ....Pure and applied nuclear structure research with radioactive ion beams at Californium Rare Ion Breeder Upgrade (CARIBU). The structure of exotic neutron-rich nuclei will be investigated at the Californium Rare Ion Breeder Upgrade (CARIBU) radioactive ion beam facility using new and novel detector systems. The results will enhance our fundamental understanding of the atomic nucleus and stellar nucleosynthesis as well as provide important data for the development of next generation nuclear reactors.Read moreRead less
The New Dimensions of the Quantum Universe. This Fellowship will help build and strengthen significant world-class research capacity at the frontier of fundamental science. More students will be motivated to pursue careers in science, increasing the number of talented, world-class science graduates in Australia. It will forge strong research links both locally and internationally so as to enhance existing networks and create new ones. It will greatly enhance Australia's standing in particle phys ....The New Dimensions of the Quantum Universe. This Fellowship will help build and strengthen significant world-class research capacity at the frontier of fundamental science. More students will be motivated to pursue careers in science, increasing the number of talented, world-class science graduates in Australia. It will forge strong research links both locally and internationally so as to enhance existing networks and create new ones. It will greatly enhance Australia's standing in particle physics, the epitome of Big Science, and garner new respect from one of the world's most influential scientific communities. Having this kind of world-class research in Australia, will also help foster public education and advance the public understanding of fundamental science.
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Branes and unification. This project will explore theories which hypothesis that our universe is a 3-dimensional mem-(brane) residing in higher dimensional space. We will construct completely realistic theories and find ways to test them experimentally. This project is at the forefront of international developments in our understanding of the universe - an area that has grown in importance following the construction of the Large Hadron Collider at the European Giant accelerator laboraroty. The p ....Branes and unification. This project will explore theories which hypothesis that our universe is a 3-dimensional mem-(brane) residing in higher dimensional space. We will construct completely realistic theories and find ways to test them experimentally. This project is at the forefront of international developments in our understanding of the universe - an area that has grown in importance following the construction of the Large Hadron Collider at the European Giant accelerator laboraroty. The project will expose postgraduate students to exciting developments in this fascinating field pf physics.Read moreRead less
Particle physics and cosmology of neutrinos. Neutrinos are a particularly interesting class of elementary particle. The Standard Model of particle physics sees neutrinos as having exactly zero mass. However, recent experimental data have all but demonstrated that massless neutrinos are inconsistent with observations. If neutrinos have mass, then quantum mechanics allows them to oscillate between the different neutrino types as they propagate through space. Nonzero neutrino masses and the associa ....Particle physics and cosmology of neutrinos. Neutrinos are a particularly interesting class of elementary particle. The Standard Model of particle physics sees neutrinos as having exactly zero mass. However, recent experimental data have all but demonstrated that massless neutrinos are inconsistent with observations. If neutrinos have mass, then quantum mechanics allows them to oscillate between the different neutrino types as they propagate through space. Nonzero neutrino masses and the associated oscillations lead to important new physics in the elementary particle domain and in cosmology. This project will explore the implications of neutrino oscillations in diverse areas in particle physics and cosmology.Read moreRead less
An Australian Program in Precision Flavour Physics. Particle physics is a breakthrough scientific endeavour, addressing fundamental questions about the nature of the laws that govern the Universe we live in. Through engaging in appropriately chosen collaborative experiments at the cutting edge of the field, Australian science can make leading contributions to a deepening understanding that flows from discoveries in this area. Excellent training of young Australian researchers, enhancement of pub ....An Australian Program in Precision Flavour Physics. Particle physics is a breakthrough scientific endeavour, addressing fundamental questions about the nature of the laws that govern the Universe we live in. Through engaging in appropriately chosen collaborative experiments at the cutting edge of the field, Australian science can make leading contributions to a deepening understanding that flows from discoveries in this area. Excellent training of young Australian researchers, enhancement of public interest in science, and fostering of international cooperation and networking are all outcomes which this project will provide.Read moreRead less
The Origin of Mass at the Large Hadron Collider. The Large Hadron Collider is an enormous worldwide effort to understand the building blocks of the Universe. This project will help strengthen world-class research capacity in one of the most exciting frontiers of basic research. It will excite more high-achieving students to pursue careers in science increasing the number of talented graduates in Australia. In addition the big fundamental questions addressed in this research are of great fascin ....The Origin of Mass at the Large Hadron Collider. The Large Hadron Collider is an enormous worldwide effort to understand the building blocks of the Universe. This project will help strengthen world-class research capacity in one of the most exciting frontiers of basic research. It will excite more high-achieving students to pursue careers in science increasing the number of talented graduates in Australia. In addition the big fundamental questions addressed in this research are of great fascination to the general public and will help to further advance the public education of science.Read moreRead less