The Role Of Capsid Protein Nucleolar Localisation In Chikungunya Virus: Implications For Vaccine Development
Funder
National Health and Medical Research Council
Funding Amount
$520,520.00
Summary
Chikungunya virus (CHIKV) is a globally widespread mosquito-borne alphavirus capable of causing considerable human morbidity and mortality. With no CHIKV vaccine or antiviral available this proposal aims to develop a live attenuated CHIKV vaccine, rationally designed by investigating the host cell nucleolar trafficking of CHIKV capsid protein. This vaccine has the potential to provide cross-protection against additional arthritogenic alphaviruses endemic to Australia such as Ross River virus.
Characterising The Beta-catenin Nuclear Targeting Pathway In Cancer
Funder
National Health and Medical Research Council
Funding Amount
$485,081.00
Summary
Bowel cancer is caused by inherited gene mutations that cause build-up of beta-catenin protein in the cell nucleus. Bowel cancer is the second largest cause of cancer deaths in Australia. We aim to study the mechanisms controlling beta-catenin accumulation in the nucleus. We will characterise new signalling pathways that control movement and activity of beta-catenin in the nucleus. This will yield insights into the role of beta-catenin in cancer and possible targets for therapy.
An Australian Program in Precision Flavour Physics. Particle physics is a breakthrough scientific endeavour, addressing fundamental questions about the nature of the laws that govern the Universe we live in. Through engaging in appropriately chosen collaborative experiments at the cutting edge of the field, Australian science can make leading contributions to a deepening understanding that flows from discoveries in this area. Excellent training of young Australian researchers, enhancement of pub ....An Australian Program in Precision Flavour Physics. Particle physics is a breakthrough scientific endeavour, addressing fundamental questions about the nature of the laws that govern the Universe we live in. Through engaging in appropriately chosen collaborative experiments at the cutting edge of the field, Australian science can make leading contributions to a deepening understanding that flows from discoveries in this area. Excellent training of young Australian researchers, enhancement of public interest in science, and fostering of international cooperation and networking are all outcomes which this project will provide.Read moreRead less
A programme to study quarkonium-like states at ATLAS. Particle physics, the study of the fundamental building blocks of matter, has pioneered the use of large collaborations --- hundreds of scientists working in dozens of countries --- to solve difficult research problems. Australian groups have contributed to several such experiments, studying cosmic rays, neutrinos, and broken symmetries, as well as developing ATLAS, a vast experiment dedicated to understanding the origin of mass. This projec ....A programme to study quarkonium-like states at ATLAS. Particle physics, the study of the fundamental building blocks of matter, has pioneered the use of large collaborations --- hundreds of scientists working in dozens of countries --- to solve difficult research problems. Australian groups have contributed to several such experiments, studying cosmic rays, neutrinos, and broken symmetries, as well as developing ATLAS, a vast experiment dedicated to understanding the origin of mass. This project seeks to use ATLAS for a new purpose: searching for exotic mesons. Our existing commitment to ATLAS provides an opportunity to develop this as a new avenue of fundamental research in this country.Read moreRead less
High Precision Silicon Pixel Detectors for High Energy Physics , Synchrotron and Medical Imaging Applications. Australia participates actively in the frontier field of high-energy particle physics to understand the fundamental building blocks of matter, their origins and interactions. This field excites the best minds in the scientific world and provides excellent training. To maintain our position in this field we must continue the development of the powerful instrumentation required for high- ....High Precision Silicon Pixel Detectors for High Energy Physics , Synchrotron and Medical Imaging Applications. Australia participates actively in the frontier field of high-energy particle physics to understand the fundamental building blocks of matter, their origins and interactions. This field excites the best minds in the scientific world and provides excellent training. To maintain our position in this field we must continue the development of the powerful instrumentation required for high-energy experiments. This project will satisfy that role. The application of particle detector expertise to state-of-the-art X-ray imaging detectors for the Australian Synchrotron and medical imaging is a perfect example of fundamental science tools applied to other fields. Australian Synchrotron experiments stand to gain much.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453432
Funder
Australian Research Council
Funding Amount
$257,250.00
Summary
Support for the Australian Experimental High Energy Physics Program. High energy particle physics studies the most fundamental constituents of matter. This microscopic frontier requires the highest energy and highest intensity particle accelerators. Through the Big Bang Model, high energy physics also sheds light on the development of the very early Universe. It is thus crucial for the understanding of nature at the very largest of scales as well as the very smallest.The ATLAS and Belle experime ....Support for the Australian Experimental High Energy Physics Program. High energy particle physics studies the most fundamental constituents of matter. This microscopic frontier requires the highest energy and highest intensity particle accelerators. Through the Big Bang Model, high energy physics also sheds light on the development of the very early Universe. It is thus crucial for the understanding of nature at the very largest of scales as well as the very smallest.The ATLAS and Belle experiments probe two of the most significant questions in fundamental physics: what is the origin of mass, and why do we live in a universe composed of matter rather than antimatter? This proposal seeks support to maintain access to the international high energy physics program in Europe and Japan.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0230224
Funder
Australian Research Council
Funding Amount
$220,255.00
Summary
Support for the Australian Experimental High Energy Physics Program. High energy particle physics studies the most fundamental constituents of matter. This microscopic frontier requires the highest energy and highest intensity particle accelerators. Through the Big Bang Model, high energy physics also sheds light on the development of the very early Universe. It is thus crucial for the understanding of nature at the very largest of scales as well as the very smallest. The ATLAS and Belle experim ....Support for the Australian Experimental High Energy Physics Program. High energy particle physics studies the most fundamental constituents of matter. This microscopic frontier requires the highest energy and highest intensity particle accelerators. Through the Big Bang Model, high energy physics also sheds light on the development of the very early Universe. It is thus crucial for the understanding of nature at the very largest of scales as well as the very smallest. The ATLAS and Belle experiments probe two of the most significant questions in fundamental physics: what is the origin of mass, and why do we live in a universe composed of matter rather than antimatter? This proposal seeks support to maintain access to the international high energy physics program in Europe and Japan.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775488
Funder
Australian Research Council
Funding Amount
$1,350,000.00
Summary
Support for the Australian Experimental High Energy Physics Program. This project will support physicists in the expected era of discovery in the knowledge of fundamental particles that makes up our Universe. Having participated in developing the giant $½ billion ATLAS experiment, Australian scientists will be making major discoveries in this era. ATLAS will hunt down the Higgs boson, to understand the origin of mass of fundamental particles. ATLAS will also search for particles to explain Dark ....Support for the Australian Experimental High Energy Physics Program. This project will support physicists in the expected era of discovery in the knowledge of fundamental particles that makes up our Universe. Having participated in developing the giant $½ billion ATLAS experiment, Australian scientists will be making major discoveries in this era. ATLAS will hunt down the Higgs boson, to understand the origin of mass of fundamental particles. ATLAS will also search for particles to explain Dark Matter, which makes 25% of our Universe. ATLAS will search for undiscovered laws of nature to help us unify our understanding of the forces of nature. Excellent training, public interest, international cooperation and networking, and national pride will be enhanced by this project.
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Frontier Experiments in High Energy Physics. High energy particle physics studies the most fundamental constituents of matter. This microscopic frontier requires the highest energy and highest intensity particle accelerators. Through the Big Bang Model, high energy physics also sheds light on the development of the very early Universe. It is thus crucial for the understanding of nature at the very largest of scales as well as the very smallest. The ATLAS and Belle experiments probe two of the mo ....Frontier Experiments in High Energy Physics. High energy particle physics studies the most fundamental constituents of matter. This microscopic frontier requires the highest energy and highest intensity particle accelerators. Through the Big Bang Model, high energy physics also sheds light on the development of the very early Universe. It is thus crucial for the understanding of nature at the very largest of scales as well as the very smallest. The ATLAS and Belle experiments probe two of the most significant questions in fundamental physics: what is the origin of mass, and why do we live in a universe composed of matter rather than antimatter?
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668428
Funder
Australian Research Council
Funding Amount
$295,000.00
Summary
Support for the Australian Experimental High Energy Physics Program. Working at the cutting edge of international research, using facilities and collaborating with scientists of the highest calibre from the world over, provides an outstanding capability for Australian science that cannot be met with local facilities alone. High energy physics is the premier example of successful international collaboration. Search and discovery in fundamental physics is the best training ground for our future sc ....Support for the Australian Experimental High Energy Physics Program. Working at the cutting edge of international research, using facilities and collaborating with scientists of the highest calibre from the world over, provides an outstanding capability for Australian science that cannot be met with local facilities alone. High energy physics is the premier example of successful international collaboration. Search and discovery in fundamental physics is the best training ground for our future scientists. Technology transfer to local companies and training of scientific and technical staff are important outcomes of this project. The Australian public is fascinated by results and discussion about the origins of the Universe, at the centre of this project.Read moreRead less