Regulation Of The Tumour Suppressors APC And BRCA1 By Nuclear Export
Funder
National Health and Medical Research Council
Funding Amount
$530,874.00
Summary
Cancer cells lack the ability to control their own growth, and thus continously divide in their local environment, leading to tumour formation. Tumour suppressor proteins, like APC and BRCA1, normally function as regulators to help cells respond to outside signals and to stop growing when necessary. The inactivation and altered cellular localisation of tumour suppressor proteins can contribute to cancer development. We have found that the APC and BRCA1 proteins, whose inactivation leads to devel ....Cancer cells lack the ability to control their own growth, and thus continously divide in their local environment, leading to tumour formation. Tumour suppressor proteins, like APC and BRCA1, normally function as regulators to help cells respond to outside signals and to stop growing when necessary. The inactivation and altered cellular localisation of tumour suppressor proteins can contribute to cancer development. We have found that the APC and BRCA1 proteins, whose inactivation leads to development of colon cancer and breast cancer, respectively, contain signals that dictate their movement within the cell. Our novel preliminary findings reveal that APC and BRCA1 are able to move in and out of the cell nucleus. We aim to define how this occurs, and examine how the regulation of their cellular location affects the normal function of these cancer-suppressing proteins. Finally, abnormalities in the nuclear passage of APC or BRCA1 might explain their altered cellular location in cancer cells.Read moreRead less
Seafood Trade Advisory Group - Transitioning To A New Communications, Governance And Operating Model
Funder
Fisheries Research and Development Corporation
Funding Amount
$444,000.00
Summary
The STAG has been operational since 2013 providing services to Australian abalone and rock lobster exporters to engage with government and to support in market access negotiations with unified and well researched considered input. The STAG has a track record of success based on a collaborative priority setting process and a clear focus on resolving the highest priority issues. While primarily focused on the issues faced by abalone and rock lobster exporters many of the STAG activities have be ....The STAG has been operational since 2013 providing services to Australian abalone and rock lobster exporters to engage with government and to support in market access negotiations with unified and well researched considered input. The STAG has a track record of success based on a collaborative priority setting process and a clear focus on resolving the highest priority issues. While primarily focused on the issues faced by abalone and rock lobster exporters many of the STAG activities have benefited the broader seafood exporter community eg the International Freight Assistance Mechanism, tracking and communicating impacts of the COVID pandemic on markets, facilitating an agreed priority listing for adding new species to the approved import list for China and establishing a market intelligence service has been established and weekly newsletters keep Australian seafood exporters up to date on market trends and consumer insights as well as technical market access issues.
Seafood Industry Australia has recently developed a Seafood Industry Export Plan. As part of that plan SIA is building capability and has received Australian Government funding through the ATMAC funding to deliver trade facilitation services.
There is an opportunity for the STAG to move to a new expanded business model under the auspices of SIA capitalising on the resources and capacities of both organisations. The new model will include communications, governance, operations and funding. What that looks like and how that transition should occur will be addressed through application.
While the transition plan is being developed, agreed and implemented it is important that the STAG to continue operations, providing services as agreed by the Partnership Group. The international trade environment is still extremely volatile, as it has been for the past two years. The STAG provides a valuable early warning and quick response mechanism for dealing with disruptions, a market intelligence service and international seafood trade expertise to support the Abalone and Rock Lobster sectors as they face the challenging task of regaining and maintaining China market access while pursuing market diversification strategies.
There is a need to build additional seafood specific international trade knowledge and capacity so the STAG and SIA will work together to identify opportunities to facilitate this. Objectives: 1. To develop and implement agreed arrangements to transition the STAG to a new business model (communications, governance, operations and funding) within the SIA 2. To deliver agreed trade and market access services according to the agreed Seafood Trade Agenda and Action Plan for Abalone and Rock Lobster Read moreRead less
Impacts Of COVID19 On The Australian Seafood Industry: Extending The Assessment To Prepare For Uncertain Futures
Funder
Fisheries Research and Development Corporation
Funding Amount
$179,564.00
Summary
In March 2021 the FRDC published an initial rapid assessment - Impacts of COVID19 on the Australian Seafood Industry: January-June 2020 - of the direct and indirect effects of disruption to seafood production, supply chains and markets caused by the global COVID19 pandemic. That assessment covered the initial period of the shocks wrought by COVID19 and demonstrated the availability of data to support rapid assessment in such conditions.
However gaps remain to be addressed, including: < ....In March 2021 the FRDC published an initial rapid assessment - Impacts of COVID19 on the Australian Seafood Industry: January-June 2020 - of the direct and indirect effects of disruption to seafood production, supply chains and markets caused by the global COVID19 pandemic. That assessment covered the initial period of the shocks wrought by COVID19 and demonstrated the availability of data to support rapid assessment in such conditions.
However gaps remain to be addressed, including: 1. comprehensive coverage of production effects in fishing and aquaculture across all Australian jurisdictions, 2. coverage of impacts on recreational fishing activity and Indigenous commercial seafood activities; 3. assessment of emerging medium-term impacts (such as changes in Australian consumer purchasing behaviours, structural effects in labour markets and export-oriented sectors, effects of alterations in tourism patterns); and the interactions with non-CV-19 impacts (such as trade tensions affecting exports); and 4. the effectiveness of crisis responses. Furthermore, the capacity to access data to support rapid assessment in times of systemic shock needs to be consolidated. Finally, insights from rapid assessments need to be harvested to provide Australia with a framework for assessment of systemic (i.e. large-scale, multi-level) risk to the Australian seafood community.
This project addresses these needs through a follow-up Impact assessment report which is more comprehensive, given data availability. The follow up report will include case studies of crisis responses by key government and industry decision makers, and the lessons learned for preparedness for future shocks. It will develop a Guideline for rapid assessment of economic and social effects in fisheries and aquaculture, which will contribute to FRDC's capacity for rapid appraisal and assessments. The guideline will include quality assurance steps to be applied to rapid assessments. Finally, the project proposes to draw insights from this more comprehensive assessment to identify what risk factors to assess, and how, in order to prepare for systemic shocks in future. Objectives: 1. Complete assessment of impact of COVID-19 on Australia's commercial, recreational and charter fisheries and aquaculture sectors for the period July 2020 to June 2021 2. Determine what were effective responses and interventions using selected case studies to inform preparedness for future shocks 3. Document all data streams and their source (organisation, private data, public domain data) - STOP / GO MILESTONE 4. Develop guidelines for data production, governance and use when rapid situational assessments are required. 5. Develop a framework for systematic risk assessment 6. Develop 'data architecture' for a portal to access live/near-real time data to support early detection and risk assessment of large-scale shocks (architecture to include: data sources, access and permissions; display; outputs) Read moreRead less