Understanding how cells compact and segregate DNA in vertebrates. How a cell compacts and divides its DNA is still a major unanswered question in biology. This project will determine the way in which a cell compacts its DNA nearly ten thousand fold to allow the faithful and accurate segregation to daughter nuclei.
Investigating a novel factor impacting stem cell development. This project aims to investigate how stem cells are controlled during animal development, by exploring how a specific protein, essential for embryonic development, controls cell fate decisions during the early stages of life. This project expects to generate new knowledge in stem cell biology, embryonic development, and general mechanisms controlling cell fates, using innovative approaches in gene editing and high-throughput imaging. ....Investigating a novel factor impacting stem cell development. This project aims to investigate how stem cells are controlled during animal development, by exploring how a specific protein, essential for embryonic development, controls cell fate decisions during the early stages of life. This project expects to generate new knowledge in stem cell biology, embryonic development, and general mechanisms controlling cell fates, using innovative approaches in gene editing and high-throughput imaging. Expected outcomes of this project include enhanced capacity for fundamental stem cell biology in Australia. This should provide significant benefits, such as training of young Australian researchers in frontier technologies, and new knowledge in fundamental aspects of life, including embryonic development.Read moreRead less
Controlling cell polarity and asymmetric cell division in space and time. This project seeks to increase our understanding of how cells divide. Asymmetric cell division is a specialised form of cell division essential for the development of all organisms. The two meiotic divisions of the oocyte are extreme examples of asymmetric cell division that allow a reduction in chromosome content while retaining cytoplasmic vestments necessary for development. Successful asymmetric cell division requires ....Controlling cell polarity and asymmetric cell division in space and time. This project seeks to increase our understanding of how cells divide. Asymmetric cell division is a specialised form of cell division essential for the development of all organisms. The two meiotic divisions of the oocyte are extreme examples of asymmetric cell division that allow a reduction in chromosome content while retaining cytoplasmic vestments necessary for development. Successful asymmetric cell division requires the integration of cell cycle events with cell polarity. Understanding how this is achieved would improve our understanding of how to generate a healthy embryo in women, endangered species and in animals of commercial importance.Read moreRead less
Genomic and molecular characterisation of a novel Australian leishmania pathogen. Leishmaniasis is the second most serious protozoal disease after malaria. This project will help characterise the first Leishmania species identified in Australia providing molecular tools to monitor the pathogen and a detailed assessment of any potential risk to human health. Comparative analysis with more pathogenic species will help identify genes and mechanisms that determine the progression of human disease le ....Genomic and molecular characterisation of a novel Australian leishmania pathogen. Leishmaniasis is the second most serious protozoal disease after malaria. This project will help characterise the first Leishmania species identified in Australia providing molecular tools to monitor the pathogen and a detailed assessment of any potential risk to human health. Comparative analysis with more pathogenic species will help identify genes and mechanisms that determine the progression of human disease leading to the potential identification of new drug and vaccine targets. The methodologies and expertise developed will be used will be available to other research groups working on infectious diseases.Read moreRead less
Dissecting insect gut function to understand insecticide detoxification. Massive quantities of chemical insecticides are used daily to control the insect pests that threaten agriculture, human health and the welfare of domestic pets. Insects readily evolve resistance to these chemicals reducing the effectiveness of pest control, increasing the amount of chemical used and increasing costs to consumers. This project examines the way in which insects adapt to the extreme stress imposed on them by ....Dissecting insect gut function to understand insecticide detoxification. Massive quantities of chemical insecticides are used daily to control the insect pests that threaten agriculture, human health and the welfare of domestic pets. Insects readily evolve resistance to these chemicals reducing the effectiveness of pest control, increasing the amount of chemical used and increasing costs to consumers. This project examines the way in which insects adapt to the extreme stress imposed on them by chemical insecticides. A thorough understanding of this adaptation process is required before insecticide resistance can be effectively managed or prevented. Read moreRead less
Potential of gene drives to eliminate incursions of Drosophila suzukii. This project aims to test the efficacy and evolutionary stability of different types of gene drives, and model whether gene drives can be used to eliminate incursions of Drosophila suzukii into Australia. It is now possible to use genome editing technology to alter populations of organisms using ‘gene drives’. Multiple strategies have been conceived with a major distinction between those that aim to eliminate populations ver ....Potential of gene drives to eliminate incursions of Drosophila suzukii. This project aims to test the efficacy and evolutionary stability of different types of gene drives, and model whether gene drives can be used to eliminate incursions of Drosophila suzukii into Australia. It is now possible to use genome editing technology to alter populations of organisms using ‘gene drives’. Multiple strategies have been conceived with a major distinction between those that aim to eliminate populations versus those that aim to modify populations. This project will examine these strategies in two fly species, the model, Drosophila melanogaster and the devastating pest of horticulture, Drosophila suzukii. The project expects to assess a gene drive strategy to control the invasive pest that threatens the Australian soft-skinned fruit industries.Read moreRead less
Functional and regulatory analysis of n-acetylcholine receptors, key targets of insecticides. Agriculture is one of Australia's mainstay industries and a major user of insecticides. However, current insecticides suffer a number of significant deficiencies, including collateral damage in the environment and insect resistance. One of the major targets for insecticides are a class of neuronal receptors, found in organisms ranging from worms to man. Our work will provide a detailed biological unders ....Functional and regulatory analysis of n-acetylcholine receptors, key targets of insecticides. Agriculture is one of Australia's mainstay industries and a major user of insecticides. However, current insecticides suffer a number of significant deficiencies, including collateral damage in the environment and insect resistance. One of the major targets for insecticides are a class of neuronal receptors, found in organisms ranging from worms to man. Our work will provide a detailed biological understanding of these receptors leading to better ways of developing new insecticides. Similar receptors in humans are the target for nicotine and associated with neurological disorders such as schizophrenia and autism. Thus our work will also increase our understanding of important human receptors associated with disease.Read moreRead less
The genomics of adaptation in Wolbachia pipientis, an emerging biocontrol agent. Australians are increasingly exposed to insect-transmitted diseases such as dengue fever. Novel biocontrol methods using the bacterium Wolbachia aim to control insect populations to reduce disease transmission. Our research will be the first to investigate genomic variation and the process of adaptation to new insect hosts in Wolbachia. The novel data and understanding of evolutionary processes we generate will be c ....The genomics of adaptation in Wolbachia pipientis, an emerging biocontrol agent. Australians are increasingly exposed to insect-transmitted diseases such as dengue fever. Novel biocontrol methods using the bacterium Wolbachia aim to control insect populations to reduce disease transmission. Our research will be the first to investigate genomic variation and the process of adaptation to new insect hosts in Wolbachia. The novel data and understanding of evolutionary processes we generate will be critical for screening bacterial biocontrol candidates and designing biocontrol release strategies. It will also strengthen the position of Australian research as a world-leader in the fusion of post-genomics and applied microbiology. Read moreRead less
MitoGenomics of Key Pathogens - An International Research Co-operative. The national/community benefits are: (1) to develop a long-term, high quality scientific and technological program contributing to national objectives, including the maintenance of a strong capability in basic research, the development of new scientific concepts and the enhancement of international collaborative links; (2) to strengthen the links between basic and applied research; (3) to develop excellence in research by pr ....MitoGenomics of Key Pathogens - An International Research Co-operative. The national/community benefits are: (1) to develop a long-term, high quality scientific and technological program contributing to national objectives, including the maintenance of a strong capability in basic research, the development of new scientific concepts and the enhancement of international collaborative links; (2) to strengthen the links between basic and applied research; (3) to develop excellence in research by promoting collaborative research, resulting in a more efficient use of resources in a national and international context; (4) to enhance the skills-base in biology and biotechnology; (5) to substantially increase global visibility through quality research, leading to an increased investment in Australian science.Read moreRead less
Olfactory signal transduction in Drosophila melanogaster. This project will strengthen Australia's research capabilities in the areas of molecular neurobiology and neurogenetics. The project will equip students with the intellectual and technical skills needed to work in priority areas such as genomics and biotechnology, as well as in medical and agricultural research, and education. The research has possible long term applications in modifying the behaviour of insects of agricultural or medical ....Olfactory signal transduction in Drosophila melanogaster. This project will strengthen Australia's research capabilities in the areas of molecular neurobiology and neurogenetics. The project will equip students with the intellectual and technical skills needed to work in priority areas such as genomics and biotechnology, as well as in medical and agricultural research, and education. The research has possible long term applications in modifying the behaviour of insects of agricultural or medical importance. For example, by inhibiting the ability of insects to perceive specific odours it may ultimately be possible to prevent insects that carry disease from identifying target animals, or plant pests from locating their host plants.Read moreRead less