Radiation protection for space, aviation, and terrestrial applications: the development of novel radiation detectors and computational techniques. Personnel in space, aviation, and terrestrial applications may be exposed to potentially harmful levels of densely ionising radiation. This project will produce improved radiation detectors and computational techniques, addressing needs in the prediction and assessment of equivalent dose in these applications. The "preventative healthcare" priority go ....Radiation protection for space, aviation, and terrestrial applications: the development of novel radiation detectors and computational techniques. Personnel in space, aviation, and terrestrial applications may be exposed to potentially harmful levels of densely ionising radiation. This project will produce improved radiation detectors and computational techniques, addressing needs in the prediction and assessment of equivalent dose in these applications. The "preventative healthcare" priority goal of the National Research Priority "Promoting and Maintaining Good Health" will be addressed, serving to reduce the risk to personnel involved in such activities. This research will also enhance Australia's international reputation in this field, stimulate local expertise, and create a critical mass of researchers in this field. Read moreRead less
Development of innovative radiation detectors and computational techniques for improving quality of life. This project will produce improved radiation detectors and advanced computational techniques, addressing needs in the prediction and assessment of the effects of radiation in homeland security, medicine, aviation and space applications. The 'preventative healthcare' priority goal of the National Research priority 'Promoting and maintaining good health' will be addressed, serving to reduce th ....Development of innovative radiation detectors and computational techniques for improving quality of life. This project will produce improved radiation detectors and advanced computational techniques, addressing needs in the prediction and assessment of the effects of radiation in homeland security, medicine, aviation and space applications. The 'preventative healthcare' priority goal of the National Research priority 'Promoting and maintaining good health' will be addressed, serving to reduce the risk to people involved in such activities. This fundamental research will also enhance Australia's international reputation in this field, stimulate local expertise and create a critical mass of researchers working in this sector.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0454184
Funder
Australian Research Council
Funding Amount
$155,792.00
Summary
Silicon Imaging Device Construction Facility - Wirebonder. The development of state-of-the-art, high precision semiconductor imaging devices (for high energy particle physics, synchrotron science and medical imaging ) requires a significant capability in modern assembly facilities. In constructing test and 'production' modules consisting of fine-grained, multi-channel bare silicon or other semiconductor imaging devices and custom electronic chips, a high-reliability, highly flexible wire-bonding ....Silicon Imaging Device Construction Facility - Wirebonder. The development of state-of-the-art, high precision semiconductor imaging devices (for high energy particle physics, synchrotron science and medical imaging ) requires a significant capability in modern assembly facilities. In constructing test and 'production' modules consisting of fine-grained, multi-channel bare silicon or other semiconductor imaging devices and custom electronic chips, a high-reliability, highly flexible wire-bonding machine is an essential tool. The international reputation from success in several challenging projects under difficult conditions, gained by the Chief Investigators has resulted in several more projects being planned in addition to a foreseen program of device development. A modern wirebonder, to replace the existing 30 year-old machine, has become critical to maintain our leading position in this area.Read moreRead less
Rare isotopes as tracers of prosthesis debris. The incidence of knee replacement surgery in Australia is 30,000 per year. Limited by wear debris, the lifespan of knee implants is only 10-15 years and can be much shorter. Due to increasing life expectancy, many patients need several surgical procedures. As a multi-disciplinary team of materials-, isotope-tracing- and medical-experts, we aim to understand and monitor wear debris in prostheses. Knee replacement surgery alone imposes a high burden o ....Rare isotopes as tracers of prosthesis debris. The incidence of knee replacement surgery in Australia is 30,000 per year. Limited by wear debris, the lifespan of knee implants is only 10-15 years and can be much shorter. Due to increasing life expectancy, many patients need several surgical procedures. As a multi-disciplinary team of materials-, isotope-tracing- and medical-experts, we aim to understand and monitor wear debris in prostheses. Knee replacement surgery alone imposes a high burden of annually half a billion dollars on the Australian health budget. Controlling and reducing wear debris in prosthesis joints would reduce these costs and improve patients' quality of life.Read moreRead less
Fibre Optic Dosimeters for Medical and Environmental Applications. We will develop fibre optic dosimeters for environmental monitoring and radiation therapy. A novel approach using refractive index gradients will be used to capture scintillator light while rejecting noise. New knowledge will be gained of the mechanisms of radiation damage in scintillators and glasses. The small, flexible, accurate fibre optic dosimeters will be equivalent in absorbing characteristics to human tissue, making them ....Fibre Optic Dosimeters for Medical and Environmental Applications. We will develop fibre optic dosimeters for environmental monitoring and radiation therapy. A novel approach using refractive index gradients will be used to capture scintillator light while rejecting noise. New knowledge will be gained of the mechanisms of radiation damage in scintillators and glasses. The small, flexible, accurate fibre optic dosimeters will be equivalent in absorbing characteristics to human tissue, making them superior to all currently available dosimeters. Fibre optic dosimeters will enable new adaptive radiotherapy techniques and provide quality assurance of dose delivery in radiotherapy. Their multiplexing capability will lead to applications in monitoring of workplaces and aerospace environments.Read moreRead less
Analysis, Optimization, and Control of Scanning Atomic Force Microscope Micro-Cantilever Probes. Atomic Force Microscopes (AFM's) are widely used for the examination of samples smaller than can be observed with an optical microscope. A tiny 'finger', only a few atoms wide at its sharpest point, is used to 'feel' the surface of a sample. This project aims to increase the resolution of AFM images by actively controlling the sensor probe dynamics.
Better quality AFM images would allow scientists ....Analysis, Optimization, and Control of Scanning Atomic Force Microscope Micro-Cantilever Probes. Atomic Force Microscopes (AFM's) are widely used for the examination of samples smaller than can be observed with an optical microscope. A tiny 'finger', only a few atoms wide at its sharpest point, is used to 'feel' the surface of a sample. This project aims to increase the resolution of AFM images by actively controlling the sensor probe dynamics.
Better quality AFM images would allow scientists to further investigate the atomic and molecular structure of such samples as: metals, polymers, cells, and proteins.
This research will contribute to the design of an Australian made Scanning Probe Microscope. Development of local expertise will provide a valuable resource for Australian scientific and industrial research.
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Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or t ....Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or the acute exacerbation of existing disease. The impact of these new technologies on the early diagnosis and improved triaging of patients in emergency departments is potentially profound and could result in improved healthcare outcomes for the patients and reduced admissions to hospital as well as the development of a substantial international market.Read moreRead less
Hybrid Sensor-based Physiological Control of an Implantable Rotary Blood Pump. With over 11 million people needing heart transplants worldwide and only 3000 donor hearts, an effective alternative therapy is needed. The Ventracor Ltd. rotary blood pump is one possible approach whereby a fully implantable mechanical device assists the failing heart. The innovative steps in this research proposal will be a means to robustly and safely control the speed of the pump to meet the metabolic needs of the ....Hybrid Sensor-based Physiological Control of an Implantable Rotary Blood Pump. With over 11 million people needing heart transplants worldwide and only 3000 donor hearts, an effective alternative therapy is needed. The Ventracor Ltd. rotary blood pump is one possible approach whereby a fully implantable mechanical device assists the failing heart. The innovative steps in this research proposal will be a means to robustly and safely control the speed of the pump to meet the metabolic needs of the body. Apart from the obvious health benefits for patients, this will provide the company with a huge market advantage that will also help to bolster the Australian medical device industry.Read moreRead less
Robust estimation of cardiac output and oxygen consumption from simple non-invasive physiological variables. We aim to develop robust mathematical and physiological models to estimate cardiac output and oxygen consumption of an exercising individual from simple non-invasive physiological parameters such as heart rate, respiration, body temperature and body movement (using multiple triaxial accelerometers).
The models developed will provide a better understanding of the human cardiovascular s ....Robust estimation of cardiac output and oxygen consumption from simple non-invasive physiological variables. We aim to develop robust mathematical and physiological models to estimate cardiac output and oxygen consumption of an exercising individual from simple non-invasive physiological parameters such as heart rate, respiration, body temperature and body movement (using multiple triaxial accelerometers).
The models developed will provide a better understanding of the human cardiovascular system response to exercise, and could be incorporated as part of a closed loop control system for cardiac pacemakers and/or heart assist devices.
Outcomes will include increased scientific knowledge, new robust models of the exercising cardiovascular /respiratory / thermoregulatory system and advanced biomedical instrumentation.
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