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Novel Methods For Debridement Of Dental Implant Surfaces Contaminated By A Dental Biofilm
Funder
National Health and Medical Research Council
Funding Amount
$132,653.00
Summary
Dental implants are becoming more commonly used to replace missing teeth. This process occurs by the bone fusing to the implant. However over time, bone loss and inflammation around a dental implant can occur. This response can occur after some years and can lead to eventual loss of the implant. The major contributing factors are patient susceptibility and the formation of plaque on the surface of the implant. The aims of this PhD are to understand how plaque grows on the implant surface and how ....Dental implants are becoming more commonly used to replace missing teeth. This process occurs by the bone fusing to the implant. However over time, bone loss and inflammation around a dental implant can occur. This response can occur after some years and can lead to eventual loss of the implant. The major contributing factors are patient susceptibility and the formation of plaque on the surface of the implant. The aims of this PhD are to understand how plaque grows on the implant surface and how it can be removed.Read moreRead less
Remote Ischaemic Preconditioning And Its Effect On Coronary Physiology And Platelet And Leukocyte Activation.
Funder
National Health and Medical Research Council
Funding Amount
$124,608.00
Summary
Remote ischaemic preconditioning (RIPC) is a novel treatment which can improve patient outcomes after a heart attack, undergoing coronary stenting or bypass surgery. The mechanisms by which RIPC confers this cardio-protection is not clear. We will study the effects of RIPC on platelet activity and the flow of blood in the arteries that supply the heart. Understanding RIPC may open new avenues for treatment of patients with coronary artery disease, one of the major causes of death in Australia.
Risk Stratification And Early Interventions In Pulmonary Vascular Disease: From Acute Pulmonary Embolisms To Chronic Pulmonary Hypertension
Funder
National Health and Medical Research Council
Funding Amount
$99,682.00
Summary
Pulmonary embolism (PE) is a common, potentially life-threatening condition with up to 50% of survivors developing long-term complications, which are associated with breathlessness, functional limitation and risk of premature death if not diagnosed and treated promptly. This project investigates the use of non-invasive scan techniques and exercise testing for early detection of these complications. The project will also explore new drug targets to treat these complications.
Personalised Treatment In Melanoma: Matching Optimal Drug Therapies For Individual Patients To Improve Survival.
Funder
National Health and Medical Research Council
Funding Amount
$132,743.00
Summary
The best treatment for melanoma currently is immunotherapy. However, most patients become resistant to immunotherapy after an initial response. When this occurs, patients are treated with new medications, often in a clinical trial. Unfortunately, doctors cannot predict if a patient is going to respond to a particular new treatment. This project will study the makeup of individual melanomas and use this to recommend which new treatment is most likely to work for the patient.
MRNA Expression Profiling Of Chronic Lymphocytic Leukaemia (CLL) Cells From In Vivo Hypoxic Microenvironmental Niches; Applications For In Vitro Research And Clinical Management.
Funder
National Health and Medical Research Council
Funding Amount
$124,676.00
Summary
Chronic lymphocytic lymphoma (CLL) is the most frequently diagnosed leukaemia in adults and is still considered incurable. CLL cells proliferate in the lymph nodes and bone marrow; these are areas of the human body that are hypoxic when compared to blood. These hypoxic areas affect CLL cell survival, proliferation and treatment resistance. Changes that occur to CLL cells in these areas can be measured by gene expression profiling and modeled in a lab setting to identify targets for treatment.