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Mammalian chitinases and gene therapy: new weapons to combat fungal and insect attack in mammals. Plants combat fungal and insect attack by producing chitin degrading enzymes. Related, chitinolytic enzymes have been identified in mammals, but their functions are unclear. We found that chitinases from human macrophages inhibited fungal growth. We hypothesise that, like plants, mammalian chitinases are produced to fight chitin containing pathogens. We will transform cells with a chitotriosidase ge ....Mammalian chitinases and gene therapy: new weapons to combat fungal and insect attack in mammals. Plants combat fungal and insect attack by producing chitin degrading enzymes. Related, chitinolytic enzymes have been identified in mammals, but their functions are unclear. We found that chitinases from human macrophages inhibited fungal growth. We hypothesise that, like plants, mammalian chitinases are produced to fight chitin containing pathogens. We will transform cells with a chitotriosidase gene and encapsulate them, creating bioreactors secreting chitinases. Therapeutic effects will be tested by grafting bioreactors to mice inoculated with Aspergillus. The research is a new approach to fighting chitin containing pathogens, with potential applications from parasite infestations in livestock to fungal infections in humans.Read moreRead less
Levelling the Playing Field: Starting with the School Playground. This project aims to demonstrate the effectiveness of simple, cost-effective programs for changing the way parents and teachers view manageable risk-taking for children with disabilities and increasing the level of responsibility that children take for their own actions. The well-being of all children with disabilities is at risk and the gap continues to widen. New programs, such as the National Disability Insurance Scheme, will p ....Levelling the Playing Field: Starting with the School Playground. This project aims to demonstrate the effectiveness of simple, cost-effective programs for changing the way parents and teachers view manageable risk-taking for children with disabilities and increasing the level of responsibility that children take for their own actions. The well-being of all children with disabilities is at risk and the gap continues to widen. New programs, such as the National Disability Insurance Scheme, will place increasing demands on young people with disabilities. Innovative approaches are desperately. Such programming must begin early, by including children in an age-appropriate ways and simultaneously addressing the issues of adults who have the most significant influence: parents and teachers.Read moreRead less
Development of Acid Degradable Polymeric Nanoparticles for Intracellular and Tumour Site Selective Delivery of Drugs. There is an enormous need to develop effective anticancer drug delivery systems to reduce the social and economic impact of cancer. One of the most critical problems in tumour treatment is the lack of selective toxicity of anticancer drugs against tumour tissues. Our multidisciplinary team will aim to develop a novel polymer based system for tumour site-selective delivery of anti ....Development of Acid Degradable Polymeric Nanoparticles for Intracellular and Tumour Site Selective Delivery of Drugs. There is an enormous need to develop effective anticancer drug delivery systems to reduce the social and economic impact of cancer. One of the most critical problems in tumour treatment is the lack of selective toxicity of anticancer drugs against tumour tissues. Our multidisciplinary team will aim to develop a novel polymer based system for tumour site-selective delivery of anticancer drugs. Development of such advanced drug delivery systems will significantly enhance Australia`s power in biotechnology. Development and/or formation of strategies to improve the health quality of Australians, is an important anticipated outcome of this innovative project.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100413
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Neurobiology of parenting and disruptive behaviour disorders in childhood. This project aims to examine the genetic determinants and contribution of parenting to childhood disruptive behaviour disorders. These disorders are often chronic and associated with comorbid conditions in later life, creating enormous personal and social costs for individuals and families, and a burden on the economy. About a third of children do not respond to current forms of early intervention, so clinicians need evid ....Neurobiology of parenting and disruptive behaviour disorders in childhood. This project aims to examine the genetic determinants and contribution of parenting to childhood disruptive behaviour disorders. These disorders are often chronic and associated with comorbid conditions in later life, creating enormous personal and social costs for individuals and families, and a burden on the economy. About a third of children do not respond to current forms of early intervention, so clinicians need evidence of the interaction between parenting practices and the developmental aspects of these disorders This project will examine oxytocin genetics in toddlers with disruptive behaviour disorders and their parents, to ultimately identify the genetic, family, and developmental processes that shape persistent disorders.Read moreRead less
The flipside of noise: Does it benefit listening and learning? People with low attention capacity can experience improvements in cognitive function (eg memory) in the presence of external white noise. This project aims to determine the brain mechanisms for this improvement and how it affects oral language comprehension and verbal learning. In doing so, the research would change the prevailing view that noise is always detrimental to mental processes, and provide a theoretical framework for predi ....The flipside of noise: Does it benefit listening and learning? People with low attention capacity can experience improvements in cognitive function (eg memory) in the presence of external white noise. This project aims to determine the brain mechanisms for this improvement and how it affects oral language comprehension and verbal learning. In doing so, the research would change the prevailing view that noise is always detrimental to mental processes, and provide a theoretical framework for predicting how an individual’s cognitive capacity is affected by the presence of noise. It may support the development of methods to improve educational participation and outcomes for children, particularly those with lower attention, and for older adults.Read moreRead less
Development and Evaluation of Well-Defined Polymer-RNA Conjugates as Improved Therapeutics. Gene-based drugs offer an enormous potential to treat a wide range of diseases including, but not limited to, AIDS, hepatitis, and cancer. However, effective delivery of these drugs in body is needed to convert their therapeutic potential to clinically applicable treatments. Our multidisciplinary team will aim to develop novel, polymer-gene hybrid materials for efficient delivery of gene based therapeuti ....Development and Evaluation of Well-Defined Polymer-RNA Conjugates as Improved Therapeutics. Gene-based drugs offer an enormous potential to treat a wide range of diseases including, but not limited to, AIDS, hepatitis, and cancer. However, effective delivery of these drugs in body is needed to convert their therapeutic potential to clinically applicable treatments. Our multidisciplinary team will aim to develop novel, polymer-gene hybrid materials for efficient delivery of gene based therapeutics. Development of such advanced drug delivery systems will significantly enhance Australia`s power in biotechnology. Development and/or formation of new materials and strategies to improve the health quality of Australians, is an important anticipated outcome of this innovative project. Read moreRead less
Influence of an innovative shoe design on lower limb joint loading during walking. This project will provide new knowledge about the effects of shoe design features on lower limb loading and the influence of obesity and knee condition on the shoe-mediated biomechanical effects. This will be of relevance to researchers and clinicians. It is also likely to contribute to a marketable commercial product, a shoe designed to reduce knee loading. This shoe has the potential to contribute to reducing th ....Influence of an innovative shoe design on lower limb joint loading during walking. This project will provide new knowledge about the effects of shoe design features on lower limb loading and the influence of obesity and knee condition on the shoe-mediated biomechanical effects. This will be of relevance to researchers and clinicians. It is also likely to contribute to a marketable commercial product, a shoe designed to reduce knee loading. This shoe has the potential to contribute to reducing the societal and personal burden of knee osteoarthritis, one of the most prevalent and costly chronic conditions in the developed world. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100097
Funder
Australian Research Council
Funding Amount
$370,369.00
Summary
Complementary and Alternative Medicine Degrees: New Configurations of Knowledge, Professional Autonomy and the University . This project explores complementary and alternative medicine (CAM) university degrees as sites of professional and epistemological claims-making. The emergence of CAM degrees is thought to signify CAM's increased professional status in relation to biomedicine, yet the actual constitution of CAM within the university has not been studied. By identifying the factors influenci ....Complementary and Alternative Medicine Degrees: New Configurations of Knowledge, Professional Autonomy and the University . This project explores complementary and alternative medicine (CAM) university degrees as sites of professional and epistemological claims-making. The emergence of CAM degrees is thought to signify CAM's increased professional status in relation to biomedicine, yet the actual constitution of CAM within the university has not been studied. By identifying the factors influencing the form and content of CAM degrees, this project will gauge the relative autonomy of different CAM modalities and their evolving relation to biomedicine. More broadly, this project will produce a better theoretical framework for understanding the shifting relationship between knowledge, professional autonomy and the university in the context of the health professions.Read moreRead less
Real-time analysis of tumour-infiltrating T cells using novel analytical tools. By dynamic visualization of immune cells within intact tumours, we have shown that active screening for target cells optimises their anti-tumour effect. This project will develop novel mathematical/analytical tools to unravel the basic strategies that enable immune cells to position themselves at the right location at the right time.
Resonance: a digital media art work for cooperative group interaction in the rehabilitation of acquired brain injury. The project, titled 'resonance', encompasses the design and development of an interactive multimedia artwork for rehabilitation of Acquired Brain Injury (ABI). The artwork will promote cooperative group interaction between patients, enhancing their motor and cognitive recovery.