Rapid, Point Of Care Diagnostic Tests To Differentiate HA Subtypes In Patients Samples
Funder
National Health and Medical Research Council
Funding Amount
$168,293.00
Summary
A number of rapid, point-of-care tests are available for the detection of human and avian influenza types, but they vary greatly in sensitivity. In particular, these tests are based on current strains of H5 (avian) influenza, and may be unable to detect variant or pandemic strains, and negative results can give the false impression that patients do not have H5 influenza. We will develop rapid, point-of-care tests based on highly conserved parts of the virus, so that all H5 strains (current and f ....A number of rapid, point-of-care tests are available for the detection of human and avian influenza types, but they vary greatly in sensitivity. In particular, these tests are based on current strains of H5 (avian) influenza, and may be unable to detect variant or pandemic strains, and negative results can give the false impression that patients do not have H5 influenza. We will develop rapid, point-of-care tests based on highly conserved parts of the virus, so that all H5 strains (current and future) can be detected with equal sensitivity, along with the H1 and H3 strains that are currently found in man to provide a definitive diagnosis. These tests will be valuable in the identification and differentiation of pandemic influenza cases, allowing better use of public health resources, especially against a background of continuing standard (H1 and H3) influenza infections.Read moreRead less
Comprehensive Clinical Tests Of Vestibular Function To Track Vestibular Compensation And Meniere’s Disease
Funder
National Health and Medical Research Council
Funding Amount
$390,625.00
Summary
This Project will apply new, fast, safe, comprehensive, balance tests we have developed to measure the function of the balance receptors of the inner ear. We will track changes in balance function during disease and recovery in the many, and increasing, number of Australian patients with balance disorders. These tests will give us insight into changes in the inner ear associated with severe attacks of vertigo and why some patients recover so poorly after damage to inner ear balance receptors.
An abnormal blood pressure (BP) response to a clinical exercise stress test is a signal for increased cardiovascular disease risk. However, current clinical guidelines do not provide evidence based information surrounding values that may constitute this increased risk. The EXERcise stress Test collaboratION (EXERTION) aims to fill this knowledge gap via establishment of a large, national database of exercise stress test results, linked to acute and chronic cardiovascular disease outcomes.
Repeat Expansions In Neurological Disease: Discovery, Interpretation And Enhanced Diagnostics
Funder
National Health and Medical Research Council
Funding Amount
$889,937.00
Summary
Identifying the mutation or genetic cause of disease in an individual is the first step in the provision of appropriate clinical care and treatment. This diagnostic process is being revolutionised through the ability to sequence the entire human genome in a time and cost effective manner. This project will enable identification of novel and known repeat expansion using whole genome sequencing, providing rapid diagnoses and better clinical care for individuals with neurogenetic disorders.
Development Of A Glucose-6-phosphate Dehydrogenase/ Haemoglobin Point-of-care Test For Malaria Elimination
Funder
National Health and Medical Research Council
Funding Amount
$560,608.00
Summary
Malaria elimination requires the use of specific anti-malarial drugs that treat the dormant malaria parasites in the liver. The use of these drugs in people with a deficiency of the glucose-6-phosphate dehydrogenase (G6PD) enzyme can lead to the catastrophic destruction of red blood cells and severe anaemia. There is a need for new G6PD diagnostic tests that can be delivered in remote, resource poor settings. This project will develop a G6PD point-of-care test to fast-track malaria elimination.