Muir Torre Syndrome: The Role Of IHC And Genotyping In Sebaceous Neoplasia To Facilitate Prevention Strategies In Colorectal And Endometrial Cancer
Funder
National Health and Medical Research Council
Funding Amount
$396,786.00
Summary
Sebaceous neoplasia (SN), may be an early warning sign for Lynch syndrome (LS), an inherited cancer predisposition caused by mutations in a group of genes. There are high lifetime risks of bowel and uterine cancer, for which there are effective risk management plans if the risk is known. Clinicians are challenged by the role of SN in identifying LS. At present, it is hard to differentiate. We aim to determine features to improve the diagnosis of LS carriers.
Global Lithospheric Architecture Mapping II. The continents have been rifted, or broken up, and collided, or re-assembled, along major zones of weakness many times throughout Earth's history. Boundaries between such continental domains focus large-scale movements of fluids that can produce giant ore deposits. This study will provide new perspectives on the localisation of world-class economic deposits, the Earth resources on which society depends. Innovations in imaging the deep Earth beneath co ....Global Lithospheric Architecture Mapping II. The continents have been rifted, or broken up, and collided, or re-assembled, along major zones of weakness many times throughout Earth's history. Boundaries between such continental domains focus large-scale movements of fluids that can produce giant ore deposits. This study will provide new perspectives on the localisation of world-class economic deposits, the Earth resources on which society depends. Innovations in imaging the deep Earth beneath continents, and in numerical modelling, will maintain our high international profile in research relevant to National Priority 1.6 (Developing Deep Earth Resources). Unique 3D geological maps of regions down to 250km will make the composition of deep Earth regions newly accessible to geoscientists and all potential endusers.Read moreRead less
Deep Coal Mining. The occurrence of progressively larger gas outbursts, coal bumps, and the potential for the catastrophic collapse of coal pillars is of increasing importance as mining drives deeper in seams rich in methane and other hydrocarbons. This study will address this issue by examining the roles of stress level, strain-rate, gas desorption rate, and drained and undrained gas and liquid pressures in the dynamic failure of coal, while simultaneously evaluating the promise and fidelity of ....Deep Coal Mining. The occurrence of progressively larger gas outbursts, coal bumps, and the potential for the catastrophic collapse of coal pillars is of increasing importance as mining drives deeper in seams rich in methane and other hydrocarbons. This study will address this issue by examining the roles of stress level, strain-rate, gas desorption rate, and drained and undrained gas and liquid pressures in the dynamic failure of coal, while simultaneously evaluating the promise and fidelity of a variety of hazard indices and precursive signals.Read moreRead less
Biomarker-driven Applications Of Immunotherapy In Lymphoma
Funder
National Health and Medical Research Council
Funding Amount
$189,384.00
Summary
Immunotherapy is a new treatment strategy that works in many different lymphoma types but there is no successful method of predicting response or selecting patients. I aim to explore use of immunotherapy in 3 key lymphoma subtypes to identify new techniques for predicting which patients respond to treatment through prospective biomarker research using novel techniques. These aims will be achieved through a series of clinical trials of immunotherapy in lymphoma all with a biomarker research focus
Rapid approximate imaging of electromagnetic data acquired using multichannel distributed acquisition systems. This project will investigate techniques for rapid, multidimensiuonal imaging of electromagnetic data acquired using modern multichannel distributed acquisition systems. This research will provide high-resolution images of buried ore deposits at greater depths than is possible using current instruments and processing techniques.
Kimberlites and Flood Basalts: Linking Primary Melts with Mantle and Crustal Sources. Intimate relationships between kimberlites and diamonds, and between flood basalts and sulphide mineralisation make the study of deep mantle-derived magmas important to the scientific and exploration communities. The proposed research therefore represents a logical scientific step forward and is hence timely and important in this internationally competitive field, and serve as a training base for young research ....Kimberlites and Flood Basalts: Linking Primary Melts with Mantle and Crustal Sources. Intimate relationships between kimberlites and diamonds, and between flood basalts and sulphide mineralisation make the study of deep mantle-derived magmas important to the scientific and exploration communities. The proposed research therefore represents a logical scientific step forward and is hence timely and important in this internationally competitive field, and serve as a training base for young researchers keen to learn the techniques and methodologies involved. The possible outcomes of the project are of wide interest to geoscientists, and may benefit the Australian economy in that they help to predict whether the continental magmas and respective rocks have formed in parts of deep mantle with mineralisation potential.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989986
Funder
Australian Research Council
Funding Amount
$230,000.00
Summary
Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims ....Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims to provide outstanding opportunities for the training of research students, expanding research in the fields of materials, minerals, geological, environmental and forensic science enabling to maintain Australia's lead and competitiveness in cutting edge research and technology. Read moreRead less
The Coupling of Plasticity, Microstructure and Phase Transformations in the Design of Novel Magnesium Alloys for the Automotive Industry. The desire to reduce the weight of automobiles due to legislative requirements on fuel emissions and to reduce overall fuel consumption is the driving force behind research into the development of new Mg-based alloys to replace the heavier steel and Al-alloy components in automobiles. Given the enormous worldwide transportation market and the environmental and ....The Coupling of Plasticity, Microstructure and Phase Transformations in the Design of Novel Magnesium Alloys for the Automotive Industry. The desire to reduce the weight of automobiles due to legislative requirements on fuel emissions and to reduce overall fuel consumption is the driving force behind research into the development of new Mg-based alloys to replace the heavier steel and Al-alloy components in automobiles. Given the enormous worldwide transportation market and the environmental and legislative motivation for reducing fuel emissions, the development of new Mg-based alloys capable of meeting this demand from automotive manufacturers represents both a potentially large economic advantage to the country of development as well as helping to address the environmental concern about fuel emissions.Read moreRead less
A revolution in Earth History: Life and Environment in the Neoarchaean (2.5-2.8 Ga). This research will keep Australian scientists in the forefront of studies of early life on Earth. At a time when there is a great deal of interest in this topic because of the search for similar life elsewhere in the Solar System, this work will take a prominant place in international research. It will attract leading researchers from elsewhere, with consequent intellectual benefits, and will inspire students t ....A revolution in Earth History: Life and Environment in the Neoarchaean (2.5-2.8 Ga). This research will keep Australian scientists in the forefront of studies of early life on Earth. At a time when there is a great deal of interest in this topic because of the search for similar life elsewhere in the Solar System, this work will take a prominant place in international research. It will attract leading researchers from elsewhere, with consequent intellectual benefits, and will inspire students to careers in science.Read moreRead less
A Mathematical Approach to Flexible Management of Open Pit Mines with Uncertain Geology and Unpredictable Demand. This project will create new mathematical algorithms to flexibly manage open pit mining projects. The development of strategic plans for mining operations is a highly complex task, based on incomplete geological information and uncertain future commodity demand. The smart mathematics we create will allow Australia to capitalise on upturns in international demand, while limiting unavo ....A Mathematical Approach to Flexible Management of Open Pit Mines with Uncertain Geology and Unpredictable Demand. This project will create new mathematical algorithms to flexibly manage open pit mining projects. The development of strategic plans for mining operations is a highly complex task, based on incomplete geological information and uncertain future commodity demand. The smart mathematics we create will allow Australia to capitalise on upturns in international demand, while limiting unavoidable negative outcomes, by flexibly adjusting the mining operation to prevailing geological and economic conditions. Australia's mineral exports are worth over $50b annually to the Australian economy. Our techniques will better manage Australia's mining projects and capture new, emerging markets, significantly impacting on Australia's balance of trade.Read moreRead less